Staff View: Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women

Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women

Goals: Because of shared risk factors between clinically manifest cardiovascular disease and colorectal cancer, we hypothesized the coexistence of subclinical atherosclerosis measured by coronary artery calcium (CAC) and colorectal adenoma (CRA) and that these 2 processes would also share common ris...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yun, Kyung Eun, Chang, Yoosoo, Rampal, Sanjay, Zhang, Yiyi, Cho, Juhee, Jung, Hyun Suk, Kim, Chan Won, Jeong, Chul, Cainzos-Achirica, Miguel, Zhao, Di, Pastor-Barriuso, Roberto, Shin, Hocheol, Guallar, Eliseo, Ryu, Seungho
Format:	Article
Published:	Lippincott, Williams & Wilkins 2017
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/20243/ https://doi.org/10.1097/MCG.0000000000000824
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.um.eprints.20243
record_format	eprints
spelling	my.um.eprints.202432019-01-30T06:32:31Z http://eprints.um.edu.my/20243/ Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women Yun, Kyung Eun Chang, Yoosoo Rampal, Sanjay Zhang, Yiyi Cho, Juhee Jung, Hyun Suk Kim, Chan Won Jeong, Chul Cainzos-Achirica, Miguel Zhao, Di Pastor-Barriuso, Roberto Shin, Hocheol Guallar, Eliseo Ryu, Seungho R Medicine Goals: Because of shared risk factors between clinically manifest cardiovascular disease and colorectal cancer, we hypothesized the coexistence of subclinical atherosclerosis measured by coronary artery calcium (CAC) and colorectal adenoma (CRA) and that these 2 processes would also share common risk factors. Background: No study has directly compared the risk factors associated with subclinical coronary atherosclerosis and CRA. Study: This was a cross-sectional study using multinomial logistic regression analysis of 4859 adults who participated in a health screening examination (2010 to 2011; analysis 2014 to 2015). CAC scores were categorized as 0, 1 to 100, or >100. Colonoscopy results were categorized as absent, low-risk, or high-risk CRA. Results: The prevalence of CAC>0, CAC 1 to 100 and >100 was 13.0%, 11.0%, and 2.0%, respectively. The prevalence of any CRA, low-risk CRA, and high-risk CRA was 15.1%, 13.0%, and 2.1%, respectively. The adjusted odds ratios (95% confidence interval) for CAC>0 comparing participants with low-risk and high-risk CRA with those without any CRA were 1.35 (1.06-1.71) and 2.09 (1.29-3.39), respectively. Similarly, the adjusted odds ratios (95% confidence interval) for any CRA comparing participants with CAC 1 to 100 and CAC>100 with those with no CAC were 1.26 (1.00-1.6) and 2.07 (1.31-3.26), respectively. Age, smoking, diabetes, and family history of CRC were significantly associated with both conditions. Conclusions: We observed a graded association between CAC and CRA in apparently healthy individuals. The coexistence of both conditions further emphasizes the need for more evidence of comprehensive approaches to screening and the need to consider the impact of the high risk of coexisting disease in individuals with CAC or CRA, instead of piecemeal approaches restricted to the detection of each disease independently. Lippincott, Williams & Wilkins 2017 Article PeerReviewed Yun, Kyung Eun and Chang, Yoosoo and Rampal, Sanjay and Zhang, Yiyi and Cho, Juhee and Jung, Hyun Suk and Kim, Chan Won and Jeong, Chul and Cainzos-Achirica, Miguel and Zhao, Di and Pastor-Barriuso, Roberto and Shin, Hocheol and Guallar, Eliseo and Ryu, Seungho (2017) Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women. Journal of Clinical Gastroenterology, 52 (6). pp. 508-514. ISSN 0192-0790 https://doi.org/10.1097/MCG.0000000000000824 doi:10.1097/MCG.0000000000000824
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine
spellingShingle	R Medicine Yun, Kyung Eun Chang, Yoosoo Rampal, Sanjay Zhang, Yiyi Cho, Juhee Jung, Hyun Suk Kim, Chan Won Jeong, Chul Cainzos-Achirica, Miguel Zhao, Di Pastor-Barriuso, Roberto Shin, Hocheol Guallar, Eliseo Ryu, Seungho Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women
description	Goals: Because of shared risk factors between clinically manifest cardiovascular disease and colorectal cancer, we hypothesized the coexistence of subclinical atherosclerosis measured by coronary artery calcium (CAC) and colorectal adenoma (CRA) and that these 2 processes would also share common risk factors. Background: No study has directly compared the risk factors associated with subclinical coronary atherosclerosis and CRA. Study: This was a cross-sectional study using multinomial logistic regression analysis of 4859 adults who participated in a health screening examination (2010 to 2011; analysis 2014 to 2015). CAC scores were categorized as 0, 1 to 100, or >100. Colonoscopy results were categorized as absent, low-risk, or high-risk CRA. Results: The prevalence of CAC>0, CAC 1 to 100 and >100 was 13.0%, 11.0%, and 2.0%, respectively. The prevalence of any CRA, low-risk CRA, and high-risk CRA was 15.1%, 13.0%, and 2.1%, respectively. The adjusted odds ratios (95% confidence interval) for CAC>0 comparing participants with low-risk and high-risk CRA with those without any CRA were 1.35 (1.06-1.71) and 2.09 (1.29-3.39), respectively. Similarly, the adjusted odds ratios (95% confidence interval) for any CRA comparing participants with CAC 1 to 100 and CAC>100 with those with no CAC were 1.26 (1.00-1.6) and 2.07 (1.31-3.26), respectively. Age, smoking, diabetes, and family history of CRC were significantly associated with both conditions. Conclusions: We observed a graded association between CAC and CRA in apparently healthy individuals. The coexistence of both conditions further emphasizes the need for more evidence of comprehensive approaches to screening and the need to consider the impact of the high risk of coexisting disease in individuals with CAC or CRA, instead of piecemeal approaches restricted to the detection of each disease independently.
format	Article
author	Yun, Kyung Eun Chang, Yoosoo Rampal, Sanjay Zhang, Yiyi Cho, Juhee Jung, Hyun Suk Kim, Chan Won Jeong, Chul Cainzos-Achirica, Miguel Zhao, Di Pastor-Barriuso, Roberto Shin, Hocheol Guallar, Eliseo Ryu, Seungho
author_facet	Yun, Kyung Eun Chang, Yoosoo Rampal, Sanjay Zhang, Yiyi Cho, Juhee Jung, Hyun Suk Kim, Chan Won Jeong, Chul Cainzos-Achirica, Miguel Zhao, Di Pastor-Barriuso, Roberto Shin, Hocheol Guallar, Eliseo Ryu, Seungho
author_sort	Yun, Kyung Eun
title	Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women
title_short	Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women
title_full	Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women
title_fullStr	Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women
title_full_unstemmed	Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women
title_sort	coexistence of colorectal adenomas and coronary calcification in asymptomatic men and women
publisher	Lippincott, Williams & Wilkins
publishDate	2017
url	http://eprints.um.edu.my/20243/ https://doi.org/10.1097/MCG.0000000000000824
_version_	1643691222230892544
score	13.211869

Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women

Similar Items