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Using calcium sulfate cement-Hydroxypropyl methyl cellulose/sodium alginate composites as substitutes of bone wax

Development of alternatives of bone wax to stop blood transfusion occurred in cancellous bone injury is highly deserved clinically. An ideal candidate is supposed to be not only biodegradable, biocompatible, malleable, and cost-effective, but also have comparable mechanical strength to cancellous bo...

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Main Authors: Zhou, Huan, Yang, Mengmeng, Ni, Xinye, Yang, Lei, Kutty, Muralithran Govindan
Format: Article
Published: Wiley 2017
Subjects:
RK Dentistry
Online Access:http://eprints.um.edu.my/20164/
https://doi.org/10.1111/ijac.12839
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spelling my.um.eprints.201642019-01-25T03:29:27Z http://eprints.um.edu.my/20164/ Using calcium sulfate cement-Hydroxypropyl methyl cellulose/sodium alginate composites as substitutes of bone wax Zhou, Huan Yang, Mengmeng Ni, Xinye Yang, Lei Kutty, Muralithran Govindan RK Dentistry Development of alternatives of bone wax to stop blood transfusion occurred in cancellous bone injury is highly deserved clinically. An ideal candidate is supposed to be not only biodegradable, biocompatible, malleable, and cost-effective, but also have comparable mechanical strength to cancellous bone. In the present work, calcium sulfate cement (CSC) based composites modified with hydroxypropyl methyl cellulose (HPMC) or sodium alginate (SA) were prepared. In brief, CSC was combined with 2, 4, 6 wt.% of HPMC or SA, respectively, followed by setting behavior evaluation, compressive strength and degradation testing, XRD, and SEM characterizations, as well as blood clotting induction study. Both additives improved the hemostatic performance of CSC, but CSC with 2% wt. SA exhibited the optimum setting time, mechanical strength, stability, and blood clotting ability. These results reveal the feasibility of using CSC–SA based composite as a substitute for bone wax. Wiley 2017 Article PeerReviewed Zhou, Huan and Yang, Mengmeng and Ni, Xinye and Yang, Lei and Kutty, Muralithran Govindan (2017) Using calcium sulfate cement-Hydroxypropyl methyl cellulose/sodium alginate composites as substitutes of bone wax. International Journal of Applied Ceramic Technology, 15 (4). pp. 903-909. ISSN 1546-542X https://doi.org/10.1111/ijac.12839 doi:10.1111/ijac.12839
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic RK Dentistry
spellingShingle RK Dentistry
Zhou, Huan
Yang, Mengmeng
Ni, Xinye
Yang, Lei
Kutty, Muralithran Govindan
Using calcium sulfate cement-Hydroxypropyl methyl cellulose/sodium alginate composites as substitutes of bone wax
description Development of alternatives of bone wax to stop blood transfusion occurred in cancellous bone injury is highly deserved clinically. An ideal candidate is supposed to be not only biodegradable, biocompatible, malleable, and cost-effective, but also have comparable mechanical strength to cancellous bone. In the present work, calcium sulfate cement (CSC) based composites modified with hydroxypropyl methyl cellulose (HPMC) or sodium alginate (SA) were prepared. In brief, CSC was combined with 2, 4, 6 wt.% of HPMC or SA, respectively, followed by setting behavior evaluation, compressive strength and degradation testing, XRD, and SEM characterizations, as well as blood clotting induction study. Both additives improved the hemostatic performance of CSC, but CSC with 2% wt. SA exhibited the optimum setting time, mechanical strength, stability, and blood clotting ability. These results reveal the feasibility of using CSC–SA based composite as a substitute for bone wax.
format Article
author Zhou, Huan
Yang, Mengmeng
Ni, Xinye
Yang, Lei
Kutty, Muralithran Govindan
author_facet Zhou, Huan
Yang, Mengmeng
Ni, Xinye
Yang, Lei
Kutty, Muralithran Govindan
author_sort Zhou, Huan
title Using calcium sulfate cement-Hydroxypropyl methyl cellulose/sodium alginate composites as substitutes of bone wax
title_short Using calcium sulfate cement-Hydroxypropyl methyl cellulose/sodium alginate composites as substitutes of bone wax
title_full Using calcium sulfate cement-Hydroxypropyl methyl cellulose/sodium alginate composites as substitutes of bone wax
title_fullStr Using calcium sulfate cement-Hydroxypropyl methyl cellulose/sodium alginate composites as substitutes of bone wax
title_full_unstemmed Using calcium sulfate cement-Hydroxypropyl methyl cellulose/sodium alginate composites as substitutes of bone wax
title_sort using calcium sulfate cement-hydroxypropyl methyl cellulose/sodium alginate composites as substitutes of bone wax
publisher Wiley
publishDate 2017
url http://eprints.um.edu.my/20164/
https://doi.org/10.1111/ijac.12839
_version_ 1643691198269882368
score 13.211869

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