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Risk of concentrations of major air pollutants on the prevalence of cardiovascular and respiratory diseases in urbanized area of Kuala Lumpur, Malaysia

Rapid urbanisation in Malaysian cities poses risks to the health of residents. This study aims to estimate the relative risk (RR) of major air pollutants on cardiovascular and respiratory hospitalisations in Kuala Lumpur. Daily hospitalisations due to cardiovascular and respiratory diseases from 201...

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Main Authors: Tajudin, Muhammad Abdul Basit Ahmad, Khan, Md Firoz, Mahiyuddin, Wan Rozita Wan, Hod, Rozita, Latif, Mohd Talib, Hamid, Ahmad Hazuwan, Rahman, Sufian Abd, Sahani, Mazrura
Format: Article
Published: Elsevier 2019
Subjects:
Q Science (General)
QD Chemistry
R Medicine
Online Access:http://eprints.um.edu.my/19987/
https://doi.org/10.1016/j.ecoenv.2018.12.057
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spelling my.um.eprints.199872019-01-14T08:38:24Z http://eprints.um.edu.my/19987/ Risk of concentrations of major air pollutants on the prevalence of cardiovascular and respiratory diseases in urbanized area of Kuala Lumpur, Malaysia Tajudin, Muhammad Abdul Basit Ahmad Khan, Md Firoz Mahiyuddin, Wan Rozita Wan Hod, Rozita Latif, Mohd Talib Hamid, Ahmad Hazuwan Rahman, Sufian Abd Sahani, Mazrura Q Science (General) QD Chemistry R Medicine Rapid urbanisation in Malaysian cities poses risks to the health of residents. This study aims to estimate the relative risk (RR) of major air pollutants on cardiovascular and respiratory hospitalisations in Kuala Lumpur. Daily hospitalisations due to cardiovascular and respiratory diseases from 2010 to 2014 were obtained from the Hospital Canselor Tuanku Muhriz (HCTM). The trace gases, PM10 and weather variables were obtained from the Department of Environment (DOE) Malaysia in consistent with the hospitalisation data. The RR was estimated using a Generalised Additive Model (GAM) based on Poisson regression. A “lag” concept was used where the analysis was segregated into risks of immediate exposure (lag 0) until exposure after 5 days (lag 5). The results showed that the gases could pose significant risks towards cardiovascular and respiratory hospitalisations. However, the RR value of PM10 was not significant in this study. Immediate effects on cardiovascular hospitalisations were observed for NO2 and O3 but no immediate effect was found on respiratory hospitalisations. Delayed effects on cardiovascular and respiratory hospitalisations were found with SO2 and NO2. The highest RR value was observed at lag 4 for respiratory admissions with SO2 (RR = 1.123, 95% CI = 1.045–1.207), followed by NO2 at lag 5 for cardiovascular admissions (RR = 1.025, 95% CI = 1.005–1.046). For the multi-pollutant model, NO2 at lag 5 showed the highest risks towards cardiovascular hospitalisations after controlling for O3 8 h mean lag 1 (RR = 1.026, 95% CI = 1.006–1.047), while SO2 at lag 4 showed highest risks towards respiratory hospitalisations after controlling for NO2 lag 3 (RR = 1.132, 95% CI = 1.053–1.216). This study indicated that exposure to trace gases in Kuala Lumpur could lead to both immediate and delayed effects on cardiovascular and respiratory hospitalisations. Elsevier 2019 Article PeerReviewed Tajudin, Muhammad Abdul Basit Ahmad and Khan, Md Firoz and Mahiyuddin, Wan Rozita Wan and Hod, Rozita and Latif, Mohd Talib and Hamid, Ahmad Hazuwan and Rahman, Sufian Abd and Sahani, Mazrura (2019) Risk of concentrations of major air pollutants on the prevalence of cardiovascular and respiratory diseases in urbanized area of Kuala Lumpur, Malaysia. Ecotoxicology and Environmental Safety, 171. pp. 290-300. ISSN 0147-6513 https://doi.org/10.1016/j.ecoenv.2018.12.057 doi:10.1016/j.ecoenv.2018.12.057
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
QD Chemistry
R Medicine
spellingShingle Q Science (General)
QD Chemistry
R Medicine
Tajudin, Muhammad Abdul Basit Ahmad
Khan, Md Firoz
Mahiyuddin, Wan Rozita Wan
Hod, Rozita
Latif, Mohd Talib
Hamid, Ahmad Hazuwan
Rahman, Sufian Abd
Sahani, Mazrura
Risk of concentrations of major air pollutants on the prevalence of cardiovascular and respiratory diseases in urbanized area of Kuala Lumpur, Malaysia
description Rapid urbanisation in Malaysian cities poses risks to the health of residents. This study aims to estimate the relative risk (RR) of major air pollutants on cardiovascular and respiratory hospitalisations in Kuala Lumpur. Daily hospitalisations due to cardiovascular and respiratory diseases from 2010 to 2014 were obtained from the Hospital Canselor Tuanku Muhriz (HCTM). The trace gases, PM10 and weather variables were obtained from the Department of Environment (DOE) Malaysia in consistent with the hospitalisation data. The RR was estimated using a Generalised Additive Model (GAM) based on Poisson regression. A “lag” concept was used where the analysis was segregated into risks of immediate exposure (lag 0) until exposure after 5 days (lag 5). The results showed that the gases could pose significant risks towards cardiovascular and respiratory hospitalisations. However, the RR value of PM10 was not significant in this study. Immediate effects on cardiovascular hospitalisations were observed for NO2 and O3 but no immediate effect was found on respiratory hospitalisations. Delayed effects on cardiovascular and respiratory hospitalisations were found with SO2 and NO2. The highest RR value was observed at lag 4 for respiratory admissions with SO2 (RR = 1.123, 95% CI = 1.045–1.207), followed by NO2 at lag 5 for cardiovascular admissions (RR = 1.025, 95% CI = 1.005–1.046). For the multi-pollutant model, NO2 at lag 5 showed the highest risks towards cardiovascular hospitalisations after controlling for O3 8 h mean lag 1 (RR = 1.026, 95% CI = 1.006–1.047), while SO2 at lag 4 showed highest risks towards respiratory hospitalisations after controlling for NO2 lag 3 (RR = 1.132, 95% CI = 1.053–1.216). This study indicated that exposure to trace gases in Kuala Lumpur could lead to both immediate and delayed effects on cardiovascular and respiratory hospitalisations.
format Article
author Tajudin, Muhammad Abdul Basit Ahmad
Khan, Md Firoz
Mahiyuddin, Wan Rozita Wan
Hod, Rozita
Latif, Mohd Talib
Hamid, Ahmad Hazuwan
Rahman, Sufian Abd
Sahani, Mazrura
author_facet Tajudin, Muhammad Abdul Basit Ahmad
Khan, Md Firoz
Mahiyuddin, Wan Rozita Wan
Hod, Rozita
Latif, Mohd Talib
Hamid, Ahmad Hazuwan
Rahman, Sufian Abd
Sahani, Mazrura
author_sort Tajudin, Muhammad Abdul Basit Ahmad
title Risk of concentrations of major air pollutants on the prevalence of cardiovascular and respiratory diseases in urbanized area of Kuala Lumpur, Malaysia
title_short Risk of concentrations of major air pollutants on the prevalence of cardiovascular and respiratory diseases in urbanized area of Kuala Lumpur, Malaysia
title_full Risk of concentrations of major air pollutants on the prevalence of cardiovascular and respiratory diseases in urbanized area of Kuala Lumpur, Malaysia
title_fullStr Risk of concentrations of major air pollutants on the prevalence of cardiovascular and respiratory diseases in urbanized area of Kuala Lumpur, Malaysia
title_full_unstemmed Risk of concentrations of major air pollutants on the prevalence of cardiovascular and respiratory diseases in urbanized area of Kuala Lumpur, Malaysia
title_sort risk of concentrations of major air pollutants on the prevalence of cardiovascular and respiratory diseases in urbanized area of kuala lumpur, malaysia
publisher Elsevier
publishDate 2019
url http://eprints.um.edu.my/19987/
https://doi.org/10.1016/j.ecoenv.2018.12.057
_version_ 1643691144847032320
score 13.211869

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