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Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng

Six new carbazole alkaloids, murrastanine-A (1), murrastinine-A, -B, -C (2-4), murrayatanine-A (5) and bismahanimboline (6), were isolated from the bark and leaves of Murraya koenigii (Linn.) Spreng along with 24 known carbazole alkaloids. The structure of these compounds were elucidated by extensiv...

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Main Authors: Tan, Siow Ping, Ali, Abdul Manaf, Nafiah, Mohd Azlan, Awang, Khalijah, Ahmad, Kartini
Format: Article
Published: Elsevier 2015
Subjects:
Q Science (General)
QD Chemistry
Online Access:http://eprints.um.edu.my/19613/
http://dx.doi.org/10.1016/j.tet.2015.04.037
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spelling my.um.eprints.196132018-10-05T05:20:37Z http://eprints.um.edu.my/19613/ Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng Tan, Siow Ping Ali, Abdul Manaf Nafiah, Mohd Azlan Awang, Khalijah Ahmad, Kartini Q Science (General) QD Chemistry Six new carbazole alkaloids, murrastanine-A (1), murrastinine-A, -B, -C (2-4), murrayatanine-A (5) and bismahanimboline (6), were isolated from the bark and leaves of Murraya koenigii (Linn.) Spreng along with 24 known carbazole alkaloids. The structure of these compounds were elucidated by extensive spectroscopic analysis. Murrastinine-C (4) and murrayatanine-A (5) exhibited cytotoxic activity against HL-60 and HeLa (CD50<20 μg/mL) via MTT assay. Elsevier 2015 Article PeerReviewed Tan, Siow Ping and Ali, Abdul Manaf and Nafiah, Mohd Azlan and Awang, Khalijah and Ahmad, Kartini (2015) Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng. Tetrahedron, 71 (23). pp. 3946-3953. ISSN 0040-4020 http://dx.doi.org/10.1016/j.tet.2015.04.037 doi:10.1016/j.tet.2015.04.037
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
QD Chemistry
spellingShingle Q Science (General)
QD Chemistry
Tan, Siow Ping
Ali, Abdul Manaf
Nafiah, Mohd Azlan
Awang, Khalijah
Ahmad, Kartini
Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng
description Six new carbazole alkaloids, murrastanine-A (1), murrastinine-A, -B, -C (2-4), murrayatanine-A (5) and bismahanimboline (6), were isolated from the bark and leaves of Murraya koenigii (Linn.) Spreng along with 24 known carbazole alkaloids. The structure of these compounds were elucidated by extensive spectroscopic analysis. Murrastinine-C (4) and murrayatanine-A (5) exhibited cytotoxic activity against HL-60 and HeLa (CD50<20 μg/mL) via MTT assay.
format Article
author Tan, Siow Ping
Ali, Abdul Manaf
Nafiah, Mohd Azlan
Awang, Khalijah
Ahmad, Kartini
author_facet Tan, Siow Ping
Ali, Abdul Manaf
Nafiah, Mohd Azlan
Awang, Khalijah
Ahmad, Kartini
author_sort Tan, Siow Ping
title Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng
title_short Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng
title_full Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng
title_fullStr Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng
title_full_unstemmed Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng
title_sort isolation and cytotoxic investigation of new carbazole alkaloids from murraya koenigii (linn.) spreng
publisher Elsevier
publishDate 2015
url http://eprints.um.edu.my/19613/
http://dx.doi.org/10.1016/j.tet.2015.04.037
_version_ 1643691038737432576
score 13.211869

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