Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity
The small-molecule inhibitor of p53-Mdm2 interaction, Nutlin-3, is known to be effective against cancers expressing wild-type (wt) p53. p53 mutations are rare in nasopharyngeal carcinoma (NPC), hence targeting disruption of p53-Mdm2 interaction to reactivate p53 may offer a promising therapeutic str...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Published: |
Spandidos Publications
2015
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/19489/ http://dx.doi.org/10.3892/or.2015.4177 |
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