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(+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble

A new neolignan, 3,4-dimethoxy-3',4'-methylenedioxy-2,9-epoxy-6,7-cyclo-1,8-neolign-11-en-5(5H)-one, which has been named (+)-kunstlerone (1), together with six known alkaloids: (+)-norboldine (2), (+)-N-methylisococlaurine (3), (+)-cassythicine (4), (+)-laurotetanine (5), (+)-boldine (6)...

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Main Authors: Mollataghi, A., Hadi, A.H., Awang, K., Mohamad, J., Litaudon, M., Mukhtar, M.R.
Format: Article
Published: MDPI 2011
Subjects:
QD Chemistry
R Medicine
Online Access:http://eprints.um.edu.my/1947/
http://www.ncbi.nlm.nih.gov/pubmed/21818061
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spelling my.um.eprints.19472014-12-26T06:42:12Z http://eprints.um.edu.my/1947/ (+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble Mollataghi, A. Hadi, A.H. Awang, K. Mohamad, J. Litaudon, M. Mukhtar, M.R. QD Chemistry R Medicine A new neolignan, 3,4-dimethoxy-3',4'-methylenedioxy-2,9-epoxy-6,7-cyclo-1,8-neolign-11-en-5(5H)-one, which has been named (+)-kunstlerone (1), together with six known alkaloids: (+)-norboldine (2), (+)-N-methylisococlaurine (3), (+)-cassythicine (4), (+)-laurotetanine (5), (+)-boldine (6) and (-)-pallidine (7), were isolated from the leaves of Beilschmiedia kunstleri. The structures were established through various spectroscopic methods notably 1D- and 2D-NMR, UV, IR and LCMS-IT-TOF. (+)- Kunstlerone (1) showed a strong antioxidant activity, with an SC(50) of 20.0 µg/mL. MDPI 2011 Article PeerReviewed Mollataghi, A. and Hadi, A.H. and Awang, K. and Mohamad, J. and Litaudon, M. and Mukhtar, M.R. (2011) (+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble. Molecules. ISSN 1420-3049 http://www.ncbi.nlm.nih.gov/pubmed/21818061 21818061
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
R Medicine
spellingShingle QD Chemistry
R Medicine
Mollataghi, A.
Hadi, A.H.
Awang, K.
Mohamad, J.
Litaudon, M.
Mukhtar, M.R.
(+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble
description A new neolignan, 3,4-dimethoxy-3',4'-methylenedioxy-2,9-epoxy-6,7-cyclo-1,8-neolign-11-en-5(5H)-one, which has been named (+)-kunstlerone (1), together with six known alkaloids: (+)-norboldine (2), (+)-N-methylisococlaurine (3), (+)-cassythicine (4), (+)-laurotetanine (5), (+)-boldine (6) and (-)-pallidine (7), were isolated from the leaves of Beilschmiedia kunstleri. The structures were established through various spectroscopic methods notably 1D- and 2D-NMR, UV, IR and LCMS-IT-TOF. (+)- Kunstlerone (1) showed a strong antioxidant activity, with an SC(50) of 20.0 µg/mL.
format Article
author Mollataghi, A.
Hadi, A.H.
Awang, K.
Mohamad, J.
Litaudon, M.
Mukhtar, M.R.
author_facet Mollataghi, A.
Hadi, A.H.
Awang, K.
Mohamad, J.
Litaudon, M.
Mukhtar, M.R.
author_sort Mollataghi, A.
title (+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble
title_short (+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble
title_full (+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble
title_fullStr (+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble
title_full_unstemmed (+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble
title_sort (+)-kunstlerone, a new antioxidant neolignan from the leaves of beilschmiedia kunstleri gamble
publisher MDPI
publishDate 2011
url http://eprints.um.edu.my/1947/
http://www.ncbi.nlm.nih.gov/pubmed/21818061
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score 13.211869

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