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Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis

Objective: Recent genome-wide association studies of colorectal cancer (CRC) have identified rs6983267 G>T and rs10505477 T>C polymorphisms as key loci in the 8q24 region to be associated with CRC. In the present study, we performed a meta-analysis to determine whether these loci are risk fact...

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Main Authors: Haerian, M.S., Haerian, B.S.
Format: Article
Published: Lippincott, Williams & Wilkins 2011
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R Medicine
Online Access:http://eprints.um.edu.my/1916/
http://www.ncbi.nlm.nih.gov/pubmed/21722176
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spelling my.um.eprints.19162014-12-26T01:21:14Z http://eprints.um.edu.my/1916/ Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis Haerian, M.S. Haerian, B.S. R Medicine Objective: Recent genome-wide association studies of colorectal cancer (CRC) have identified rs6983267 G>T and rs10505477 T>C polymorphisms as key loci in the 8q24 region to be associated with CRC. In the present study, we performed a meta-analysis to determine whether these loci are risk factors for susceptibility to CRC. Materials and Methods: We meta-analyzed the 22 included studies (47,003 cases and 45,754 controls) that evaluated the role of rs6983267 G>T and rs10505477 T>C polymorphisms with CRC risk under alternative genetic models. Results: Meta-analysis of the pooled data showed allelic and genotypic association of the rs6983267 polymorphism with CRC risk in the Asian, European, and Americans with European ancestry. Sub-analysis of the American studies showed negative results in the studies with non-identified ethnicity of the subjects. Meta-analysis of included studies of rs10505477 polymorphism identified allelic and genotypic association with CRC risk in the American subjects. Further meta-analysis of the American studies demonstrated positive results in the studies with non-identified ethnicity of the samples. Conclusion: Our data suggested that the rs6983267 G>T polymorphism is a risk factor for CRC in the Asians, European, and American with the European ancestry populations. Lippincott, Williams & Wilkins 2011-07-01 Article PeerReviewed Haerian, M.S. and Haerian, B.S. (2011) Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis. European Journal of Gastroenterology and Hepatology. ISSN 08159319 http://www.ncbi.nlm.nih.gov/pubmed/21722176 21722176
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Haerian, M.S.
Haerian, B.S.
Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis
description Objective: Recent genome-wide association studies of colorectal cancer (CRC) have identified rs6983267 G>T and rs10505477 T>C polymorphisms as key loci in the 8q24 region to be associated with CRC. In the present study, we performed a meta-analysis to determine whether these loci are risk factors for susceptibility to CRC. Materials and Methods: We meta-analyzed the 22 included studies (47,003 cases and 45,754 controls) that evaluated the role of rs6983267 G>T and rs10505477 T>C polymorphisms with CRC risk under alternative genetic models. Results: Meta-analysis of the pooled data showed allelic and genotypic association of the rs6983267 polymorphism with CRC risk in the Asian, European, and Americans with European ancestry. Sub-analysis of the American studies showed negative results in the studies with non-identified ethnicity of the subjects. Meta-analysis of included studies of rs10505477 polymorphism identified allelic and genotypic association with CRC risk in the American subjects. Further meta-analysis of the American studies demonstrated positive results in the studies with non-identified ethnicity of the samples. Conclusion: Our data suggested that the rs6983267 G>T polymorphism is a risk factor for CRC in the Asians, European, and American with the European ancestry populations.
format Article
author Haerian, M.S.
Haerian, B.S.
author_facet Haerian, M.S.
Haerian, B.S.
author_sort Haerian, M.S.
title Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis
title_short Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis
title_full Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis
title_fullStr Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis
title_full_unstemmed Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis
title_sort association of 8q24.21 locus with the risk of colorectal cancer: a systematic review and meta-analysis
publisher Lippincott, Williams & Wilkins
publishDate 2011
url http://eprints.um.edu.my/1916/
http://www.ncbi.nlm.nih.gov/pubmed/21722176
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score 13.211869

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