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Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia

Hand, foot and mouth disease (HFMD) is a prevalent contagious childhood disease typically associated with fever, oral lesions and limb exanthema. While HFMD is caused by a plethora of serotypes of viruses under the genus Enterovirus within the Picornaviridae family, Coxsackievirus A16 (CV-A16) and E...

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Main Authors: Teo, F.M.S., Nyo, M., Wong, A.A., Tan, N.W.H., Koh, M.T., Chan, Y.F., Chong, C.Y., Chu, J.J.H.
Format: Article
Language:English
Published: Nature Publishing Group 2018
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/18982/1/Cytokine_and_Chemokine_Profiling_in_Patients_with_Hand%2C_Foot_and_Mouth_Disease_in_Singapore_and_Malaysia.pdf
http://eprints.um.edu.my/18982/
http://dx.doi.org/10.1038/s41598-018-22379-6
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spelling my.um.eprints.189822018-08-07T08:42:08Z http://eprints.um.edu.my/18982/ Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia Teo, F.M.S. Nyo, M. Wong, A.A. Tan, N.W.H. Koh, M.T. Chan, Y.F. Chong, C.Y. Chu, J.J.H. R Medicine Hand, foot and mouth disease (HFMD) is a prevalent contagious childhood disease typically associated with fever, oral lesions and limb exanthema. While HFMD is caused by a plethora of serotypes of viruses under the genus Enterovirus within the Picornaviridae family, Coxsackievirus A16 (CV-A16) and Enterovirus 71 (EV-A71) are considered the main etiological agents. In recent years however, other viruses have also been isolated in considerable numbers from infected individuals in many regions, joining the legion commonly associated with HFMD. The present study investigated the cytokine and chemokine profiles of HFMD patients from Singapore and Malaysia for the first time. Comparative cohort studies of EV-A71-associated HFMD cases revealed that the Malaysia cohort had a distinct profile from the Singapore cohort, and this could be partly attributed by different EV-A71 genotypes. As the isolation of CV-A6, instead of CV-A16, had become prevalent in the Singapore cohort, it was also of particular interest to study the differential cytokine and chemokine profiles. Our data revealed that overlapping as well as unique profiles exist between the two major causative clinical isolates in the Singapore cohort. Having a better understanding of the respective immunological profiles could be useful for more accurate HFMD diagnosis, which is imperative for disease transmission control until multi-valent vaccines and/or broad-spectrum anti-viral drugs become available. Nature Publishing Group 2018 Article PeerReviewed application/pdf en http://eprints.um.edu.my/18982/1/Cytokine_and_Chemokine_Profiling_in_Patients_with_Hand%2C_Foot_and_Mouth_Disease_in_Singapore_and_Malaysia.pdf Teo, F.M.S. and Nyo, M. and Wong, A.A. and Tan, N.W.H. and Koh, M.T. and Chan, Y.F. and Chong, C.Y. and Chu, J.J.H. (2018) Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia. Scientific Reports, 8 (1). p. 4087. ISSN 2045-2322 http://dx.doi.org/10.1038/s41598-018-22379-6 doi:10.1038/s41598-018-22379-6
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine
spellingShingle R Medicine
Teo, F.M.S.
Nyo, M.
Wong, A.A.
Tan, N.W.H.
Koh, M.T.
Chan, Y.F.
Chong, C.Y.
Chu, J.J.H.
Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia
description Hand, foot and mouth disease (HFMD) is a prevalent contagious childhood disease typically associated with fever, oral lesions and limb exanthema. While HFMD is caused by a plethora of serotypes of viruses under the genus Enterovirus within the Picornaviridae family, Coxsackievirus A16 (CV-A16) and Enterovirus 71 (EV-A71) are considered the main etiological agents. In recent years however, other viruses have also been isolated in considerable numbers from infected individuals in many regions, joining the legion commonly associated with HFMD. The present study investigated the cytokine and chemokine profiles of HFMD patients from Singapore and Malaysia for the first time. Comparative cohort studies of EV-A71-associated HFMD cases revealed that the Malaysia cohort had a distinct profile from the Singapore cohort, and this could be partly attributed by different EV-A71 genotypes. As the isolation of CV-A6, instead of CV-A16, had become prevalent in the Singapore cohort, it was also of particular interest to study the differential cytokine and chemokine profiles. Our data revealed that overlapping as well as unique profiles exist between the two major causative clinical isolates in the Singapore cohort. Having a better understanding of the respective immunological profiles could be useful for more accurate HFMD diagnosis, which is imperative for disease transmission control until multi-valent vaccines and/or broad-spectrum anti-viral drugs become available.
format Article
author Teo, F.M.S.
Nyo, M.
Wong, A.A.
Tan, N.W.H.
Koh, M.T.
Chan, Y.F.
Chong, C.Y.
Chu, J.J.H.
author_facet Teo, F.M.S.
Nyo, M.
Wong, A.A.
Tan, N.W.H.
Koh, M.T.
Chan, Y.F.
Chong, C.Y.
Chu, J.J.H.
author_sort Teo, F.M.S.
title Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia
title_short Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia
title_full Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia
title_fullStr Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia
title_full_unstemmed Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia
title_sort cytokine and chemokine profiling in patients with hand, foot and mouth disease in singapore and malaysia
publisher Nature Publishing Group
publishDate 2018
url http://eprints.um.edu.my/18982/1/Cytokine_and_Chemokine_Profiling_in_Patients_with_Hand%2C_Foot_and_Mouth_Disease_in_Singapore_and_Malaysia.pdf
http://eprints.um.edu.my/18982/
http://dx.doi.org/10.1038/s41598-018-22379-6
_version_ 1643690851450224640
score 13.211869

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