Staff View: Interference Effect of Prior Explicit Information on Motor Sequence Learning in Relapsing-Remitting Multiple Sclerosis Patients

Interference Effect of Prior Explicit Information on Motor Sequence Learning in Relapsing-Remitting Multiple Sclerosis Patients

Background: Multiple sclerosis (MS) is the most widespread disabling neurological condition in young adults around the world. The purpose of this study was to investigate the impact of explicit information (EI) on motor-sequence learning in MS patients. Methods: Thirty patients with relapsing-remitt...

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Main Authors:	Zahiri, N., Abollahi, I., Nabavi, S.M., Ehsani, F., Arab, A.M., Shaw, I., Shariat, A., Shaw, B.S., Dastoorpoor, M., Danaee, M., Sangelaji, B.
Format:	Article
Published:	Penerbit Universiti Sains Malaysia 2017
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/18859/ http://dx.doi.org/10.21315/mjms2017.24.1.8
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spelling	my.um.eprints.188592018-06-08T06:10:10Z http://eprints.um.edu.my/18859/ Interference Effect of Prior Explicit Information on Motor Sequence Learning in Relapsing-Remitting Multiple Sclerosis Patients Zahiri, N. Abollahi, I. Nabavi, S.M. Ehsani, F. Arab, A.M. Shaw, I. Shariat, A. Shaw, B.S. Dastoorpoor, M. Danaee, M. Sangelaji, B. R Medicine Background: Multiple sclerosis (MS) is the most widespread disabling neurological condition in young adults around the world. The purpose of this study was to investigate the impact of explicit information (EI) on motor-sequence learning in MS patients. Methods: Thirty patients with relapsing-remitting MS (RRMS), age: 29.5 (SD = 5.6) years and 30 healthy gender-, age-, and education-matched control group participants, age: 28.8 (SD = 6.0) years, were recruited for this study. The participants in the healthy group were then randomly assigned into an EI (n = 15) group and a no-EI (n = 15) group. Similarly, the participants in the control group were then randomly assigned into EI (n = 15) and no-EI (n = 15) groups. The participants performed a serial reaction time (SRT) task and reaction times. A retention test was performed after 48 hours. Results: All participants reduced their reaction times across acquisition (MS group: 46.4 (SD = 3.3) minutes, P < 0.001, and healthy group: 39.4 (SD = 3.3) minutes, P < 0.001). The findings for the within-participants effect of repeated measures of time were significant (F(5.06, 283.7) = 71.33. P < 0.001). These results indicate that the interaction between group and time was significant (F(5.06, 283.7) = 6.44. P < 0.001), which indicated that the reaction time in both groups was significantly changed between the MS and healthy groups across times (B1 to B10). The main effect of the group (MS and healthy) (F(1, 56) = 22.78. P < 0.001) and also the main effect of no-EI vs EI (F(1, 56) = 4.71. P < 0.001) were significant. Conclusion: This study demonstrated that that RRMS patients are capable of learning new skills, but the provision of EI prior to physical practice is deleterious to implicit learning. It is sufficient to educate MS patients on the aim and general content of the training and only to provide feedback at the end of the rehabilitative session. Penerbit Universiti Sains Malaysia 2017 Article PeerReviewed Zahiri, N. and Abollahi, I. and Nabavi, S.M. and Ehsani, F. and Arab, A.M. and Shaw, I. and Shariat, A. and Shaw, B.S. and Dastoorpoor, M. and Danaee, M. and Sangelaji, B. (2017) Interference Effect of Prior Explicit Information on Motor Sequence Learning in Relapsing-Remitting Multiple Sclerosis Patients. Malaysian Journal of Medical Sciences, 24 (1). pp. 69-80. ISSN 1394-195X http://dx.doi.org/10.21315/mjms2017.24.1.8 doi:10.21315/mjms2017.24.1.8
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine
spellingShingle	R Medicine Zahiri, N. Abollahi, I. Nabavi, S.M. Ehsani, F. Arab, A.M. Shaw, I. Shariat, A. Shaw, B.S. Dastoorpoor, M. Danaee, M. Sangelaji, B. Interference Effect of Prior Explicit Information on Motor Sequence Learning in Relapsing-Remitting Multiple Sclerosis Patients
description	Background: Multiple sclerosis (MS) is the most widespread disabling neurological condition in young adults around the world. The purpose of this study was to investigate the impact of explicit information (EI) on motor-sequence learning in MS patients. Methods: Thirty patients with relapsing-remitting MS (RRMS), age: 29.5 (SD = 5.6) years and 30 healthy gender-, age-, and education-matched control group participants, age: 28.8 (SD = 6.0) years, were recruited for this study. The participants in the healthy group were then randomly assigned into an EI (n = 15) group and a no-EI (n = 15) group. Similarly, the participants in the control group were then randomly assigned into EI (n = 15) and no-EI (n = 15) groups. The participants performed a serial reaction time (SRT) task and reaction times. A retention test was performed after 48 hours. Results: All participants reduced their reaction times across acquisition (MS group: 46.4 (SD = 3.3) minutes, P < 0.001, and healthy group: 39.4 (SD = 3.3) minutes, P < 0.001). The findings for the within-participants effect of repeated measures of time were significant (F(5.06, 283.7) = 71.33. P < 0.001). These results indicate that the interaction between group and time was significant (F(5.06, 283.7) = 6.44. P < 0.001), which indicated that the reaction time in both groups was significantly changed between the MS and healthy groups across times (B1 to B10). The main effect of the group (MS and healthy) (F(1, 56) = 22.78. P < 0.001) and also the main effect of no-EI vs EI (F(1, 56) = 4.71. P < 0.001) were significant. Conclusion: This study demonstrated that that RRMS patients are capable of learning new skills, but the provision of EI prior to physical practice is deleterious to implicit learning. It is sufficient to educate MS patients on the aim and general content of the training and only to provide feedback at the end of the rehabilitative session.
format	Article
author	Zahiri, N. Abollahi, I. Nabavi, S.M. Ehsani, F. Arab, A.M. Shaw, I. Shariat, A. Shaw, B.S. Dastoorpoor, M. Danaee, M. Sangelaji, B.
author_facet	Zahiri, N. Abollahi, I. Nabavi, S.M. Ehsani, F. Arab, A.M. Shaw, I. Shariat, A. Shaw, B.S. Dastoorpoor, M. Danaee, M. Sangelaji, B.
author_sort	Zahiri, N.
title	Interference Effect of Prior Explicit Information on Motor Sequence Learning in Relapsing-Remitting Multiple Sclerosis Patients
title_short	Interference Effect of Prior Explicit Information on Motor Sequence Learning in Relapsing-Remitting Multiple Sclerosis Patients
title_full	Interference Effect of Prior Explicit Information on Motor Sequence Learning in Relapsing-Remitting Multiple Sclerosis Patients
title_fullStr	Interference Effect of Prior Explicit Information on Motor Sequence Learning in Relapsing-Remitting Multiple Sclerosis Patients
title_full_unstemmed	Interference Effect of Prior Explicit Information on Motor Sequence Learning in Relapsing-Remitting Multiple Sclerosis Patients
title_sort	interference effect of prior explicit information on motor sequence learning in relapsing-remitting multiple sclerosis patients
publisher	Penerbit Universiti Sains Malaysia
publishDate	2017
url	http://eprints.um.edu.my/18859/ http://dx.doi.org/10.21315/mjms2017.24.1.8
_version_	1643690817037008896
score	13.211869

Interference Effect of Prior Explicit Information on Motor Sequence Learning in Relapsing-Remitting Multiple Sclerosis Patients

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