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Preparation and characterization of pH dependent κ-carrageenan-chitosan nanoparticle as potential slow release delivery carrier

A polymeric carrier has high potential as active ingredient delivery vehicle owing to its biocompatibility and biodegradability. In this work, pH dependency of the oppositely charged polymers in forming nanoparticle was investigated. A positively charged chitosan and a negatively charged κ-carrageen...

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Main Authors: Yew, H.C., Misran, M.
Format: Article
Published: Springer Verlag (Germany) 2016
Subjects:
Q Science (General)
QD Chemistry
Online Access:http://eprints.um.edu.my/18781/
http://dx.doi.org/10.1007/s13726-016-0489-6
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spelling my.um.eprints.187812018-05-31T03:51:32Z http://eprints.um.edu.my/18781/ Preparation and characterization of pH dependent κ-carrageenan-chitosan nanoparticle as potential slow release delivery carrier Yew, H.C. Misran, M. Q Science (General) QD Chemistry A polymeric carrier has high potential as active ingredient delivery vehicle owing to its biocompatibility and biodegradability. In this work, pH dependency of the oppositely charged polymers in forming nanoparticle was investigated. A positively charged chitosan and a negatively charged κ-carrageenan were mixed at varied mass ratios (v/v) with a pH ranged from 3 to 6, respectively, to form nanoparticles through polyelectrolyte complexation. The main interest of this research, is to evaluate the effect of pH on the formation of stable active ingredients encapsulated nanoparticle for sustained release. Based on the FTIR result, the presence of new absorption band at 1584 cm−1 and slight shift in the spectrum, indicated the complexation of the polymers. The Zetasizer’s measurements showed that irrespective to the combination of chitosan and κ-carrageenan, increase in pH solution decreased the size and the zeta potential of the nanoparticles. Furthermore, depending on the combinations, the yield and the swelling percentage of the nanoparticle could reached up to 80 and 200%, respectively. Among the mass ratio combinations, the ratio 1:1 at pH 4 had the best physical properties. The encapsulation efficiency of the κ-carrageenan-chitosan nanoparticles exhibited higher preference towards more water soluble active ingredients, ascorbic acid as compared to caffeine and lidocaine. In addition, the slow release of active ingredients from the κ-carrageenan-chitosan nanoparticles, is plausibly due to the electrostatic interaction and compactness of the nanoparticles. Thus, they might be suitable for prolonged release applications. Springer Verlag (Germany) 2016 Article PeerReviewed Yew, H.C. and Misran, M. (2016) Preparation and characterization of pH dependent κ-carrageenan-chitosan nanoparticle as potential slow release delivery carrier. Iranian Polymer Journal, 25 (12). pp. 1037-1046. ISSN 1026-1265 http://dx.doi.org/10.1007/s13726-016-0489-6 doi:10.1007/s13726-016-0489-6
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
QD Chemistry
spellingShingle Q Science (General)
QD Chemistry
Yew, H.C.
Misran, M.
Preparation and characterization of pH dependent κ-carrageenan-chitosan nanoparticle as potential slow release delivery carrier
description A polymeric carrier has high potential as active ingredient delivery vehicle owing to its biocompatibility and biodegradability. In this work, pH dependency of the oppositely charged polymers in forming nanoparticle was investigated. A positively charged chitosan and a negatively charged κ-carrageenan were mixed at varied mass ratios (v/v) with a pH ranged from 3 to 6, respectively, to form nanoparticles through polyelectrolyte complexation. The main interest of this research, is to evaluate the effect of pH on the formation of stable active ingredients encapsulated nanoparticle for sustained release. Based on the FTIR result, the presence of new absorption band at 1584 cm−1 and slight shift in the spectrum, indicated the complexation of the polymers. The Zetasizer’s measurements showed that irrespective to the combination of chitosan and κ-carrageenan, increase in pH solution decreased the size and the zeta potential of the nanoparticles. Furthermore, depending on the combinations, the yield and the swelling percentage of the nanoparticle could reached up to 80 and 200%, respectively. Among the mass ratio combinations, the ratio 1:1 at pH 4 had the best physical properties. The encapsulation efficiency of the κ-carrageenan-chitosan nanoparticles exhibited higher preference towards more water soluble active ingredients, ascorbic acid as compared to caffeine and lidocaine. In addition, the slow release of active ingredients from the κ-carrageenan-chitosan nanoparticles, is plausibly due to the electrostatic interaction and compactness of the nanoparticles. Thus, they might be suitable for prolonged release applications.
format Article
author Yew, H.C.
Misran, M.
author_facet Yew, H.C.
Misran, M.
author_sort Yew, H.C.
title Preparation and characterization of pH dependent κ-carrageenan-chitosan nanoparticle as potential slow release delivery carrier
title_short Preparation and characterization of pH dependent κ-carrageenan-chitosan nanoparticle as potential slow release delivery carrier
title_full Preparation and characterization of pH dependent κ-carrageenan-chitosan nanoparticle as potential slow release delivery carrier
title_fullStr Preparation and characterization of pH dependent κ-carrageenan-chitosan nanoparticle as potential slow release delivery carrier
title_full_unstemmed Preparation and characterization of pH dependent κ-carrageenan-chitosan nanoparticle as potential slow release delivery carrier
title_sort preparation and characterization of ph dependent κ-carrageenan-chitosan nanoparticle as potential slow release delivery carrier
publisher Springer Verlag (Germany)
publishDate 2016
url http://eprints.um.edu.my/18781/
http://dx.doi.org/10.1007/s13726-016-0489-6
_version_ 1643690794288152576
score 13.211869

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