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Mixing in the mechanically agitated bioreactor: ‘a matter of being stirred, not shaken’

Stirred vessel bioreactors are often equipped with the standard 6-blade disc turbine without much thought for process specifications. Variations in the system parameters can in fact give rise to significant differences in mixing requirement, and failure to operate at the right conditions can result...

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Main Author: Ibrahim, S.
Format: Article
Published: The Institution of Engineers Malaysia 2007
Subjects:
TA Engineering (General). Civil engineering (General)
Online Access:http://eprints.um.edu.my/18624/
http://www.myiem.org.my/content/journal-122.aspx
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spelling my.um.eprints.186242018-04-26T08:51:33Z http://eprints.um.edu.my/18624/ Mixing in the mechanically agitated bioreactor: ‘a matter of being stirred, not shaken’ Ibrahim, S. TA Engineering (General). Civil engineering (General) Stirred vessel bioreactors are often equipped with the standard 6-blade disc turbine without much thought for process specifications. Variations in the system parameters can in fact give rise to significant differences in mixing requirement, and failure to operate at the right conditions can result in undesirable outcomes. Biological systems are sensitive to bioreactor hydrodynamics since it directly affects transport processes at the molecular level. In addition, extracellular products and filamentous microbes contribute to drastic changes in the broth characteristics over the course of fermentation, that would in turn alter the mixing needs. Poor mixing or over mixing can both have adverse effects on product quality, but inefficient equipment design leading to excessive energy requirement often goes unnoticed if there are no apparent effects on the product. This paper summarizes the basic considerations to be made for given mixing duties so as to enable operations in a calculated rather than random manner. The Institution of Engineers Malaysia 2007 Article PeerReviewed Ibrahim, S. (2007) Mixing in the mechanically agitated bioreactor: ‘a matter of being stirred, not shaken’. Journal of the Institution of Engineers, Malaysia, 68 (3). pp. 43-47. ISSN 0126-513X http://www.myiem.org.my/content/journal-122.aspx
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic TA Engineering (General). Civil engineering (General)
spellingShingle TA Engineering (General). Civil engineering (General)
Ibrahim, S.
Mixing in the mechanically agitated bioreactor: ‘a matter of being stirred, not shaken’
description Stirred vessel bioreactors are often equipped with the standard 6-blade disc turbine without much thought for process specifications. Variations in the system parameters can in fact give rise to significant differences in mixing requirement, and failure to operate at the right conditions can result in undesirable outcomes. Biological systems are sensitive to bioreactor hydrodynamics since it directly affects transport processes at the molecular level. In addition, extracellular products and filamentous microbes contribute to drastic changes in the broth characteristics over the course of fermentation, that would in turn alter the mixing needs. Poor mixing or over mixing can both have adverse effects on product quality, but inefficient equipment design leading to excessive energy requirement often goes unnoticed if there are no apparent effects on the product. This paper summarizes the basic considerations to be made for given mixing duties so as to enable operations in a calculated rather than random manner.
format Article
author Ibrahim, S.
author_facet Ibrahim, S.
author_sort Ibrahim, S.
title Mixing in the mechanically agitated bioreactor: ‘a matter of being stirred, not shaken’
title_short Mixing in the mechanically agitated bioreactor: ‘a matter of being stirred, not shaken’
title_full Mixing in the mechanically agitated bioreactor: ‘a matter of being stirred, not shaken’
title_fullStr Mixing in the mechanically agitated bioreactor: ‘a matter of being stirred, not shaken’
title_full_unstemmed Mixing in the mechanically agitated bioreactor: ‘a matter of being stirred, not shaken’
title_sort mixing in the mechanically agitated bioreactor: ‘a matter of being stirred, not shaken’
publisher The Institution of Engineers Malaysia
publishDate 2007
url http://eprints.um.edu.my/18624/
http://www.myiem.org.my/content/journal-122.aspx
_version_ 1643690747676852224
score 13.211869

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