Remarkable bone formation following gefitinib for extensive lytic bone metastasis: A report of two cases

Gefitinib inhibits the epidermal growth factor receptor tyrosine kinase and improves survival in patients with non-small-cell lung cancer. We report 2 patients with extensive lytic bony metastasis in the spine and pelvis secondary to advanced pulmonary adenocarcinoma who were treated with gefitinib...

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Bibliographic Details
Main Authors: Bashir, E.S., Kwan, A.K.N., Chan, C.Y.W., Kwan, M.K.
Format: Article
Published: Hong Kong University Press 2016
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Online Access:http://eprints.um.edu.my/18476/
http://journals.sagepub.com/doi/10.1177/1602400330
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Summary:Gefitinib inhibits the epidermal growth factor receptor tyrosine kinase and improves survival in patients with non-small-cell lung cancer. We report 2 patients with extensive lytic bony metastasis in the spine and pelvis secondary to advanced pulmonary adenocarcinoma who were treated with gefitinib and had remarkable bone formation in the lytic bone lesions in the spine and pelvis. Surgery for stabilisation was avoided.