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Distinct Biological Potential of Streptococcus gordonii and Streptococcus sanguinis Revealed by Comparative Genome Analysis

Streptococcus gordonii and Streptococcus sanguinis are pioneer colonizers of dental plaque and important agents of bacterial infective endocarditis (IE). To gain a greater understanding of these two closely related species, we performed comparative analyses on 14 new S. gordonii and 5 S. sanguinis s...

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Main Authors: Zheng, W., Tan, M.F., Old, L.A., Paterson, I.C., Jakubovics, N.S., Choo, S.W.
Format: Article
Language:English
Published: Nature Publishing Group 2017
Subjects:
RK Dentistry
Online Access:http://eprints.um.edu.my/17537/1/ZhengW_%282017%29.pdf
http://eprints.um.edu.my/17537/
https://www.nature.com/articles/s41598-017-02399-4
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spelling my.um.eprints.175372017-07-20T03:25:44Z http://eprints.um.edu.my/17537/ Distinct Biological Potential of Streptococcus gordonii and Streptococcus sanguinis Revealed by Comparative Genome Analysis Zheng, W. Tan, M.F. Old, L.A. Paterson, I.C. Jakubovics, N.S. Choo, S.W. RK Dentistry Streptococcus gordonii and Streptococcus sanguinis are pioneer colonizers of dental plaque and important agents of bacterial infective endocarditis (IE). To gain a greater understanding of these two closely related species, we performed comparative analyses on 14 new S. gordonii and 5 S. sanguinis strains using various bioinformatics approaches. We revealed S. gordonii and S. sanguinis harbor open pan-genomes and share generally high sequence homology and number of core genes including virulence genes. However, we observed subtle differences in genomic islands and prophages between the species. Comparative pathogenomics analysis identified S. sanguinis strains have genes encoding IgA proteases, mitogenic factor deoxyribonucleases, nickel/cobalt uptake and cobalamin biosynthesis. On the contrary, genomic islands of S. gordonii strains contain additional copies of comCDE quorum-sensing system components involved in genetic competence. Two distinct polysaccharide locus architectures were identified, one of which was exclusively present in S. gordonii strains. The first evidence of genes encoding the CylA and CylB system by the α-haemolytic S. gordonii is presented. This study provides new insights into the genetic distinctions between S. gordonii and S. sanguinis, which yields understanding of tooth surfaces colonization and contributions to dental plaque formation, as well as their potential roles in the pathogenesis of IE. Nature Publishing Group 2017 Article PeerReviewed application/pdf en http://eprints.um.edu.my/17537/1/ZhengW_%282017%29.pdf Zheng, W. and Tan, M.F. and Old, L.A. and Paterson, I.C. and Jakubovics, N.S. and Choo, S.W. (2017) Distinct Biological Potential of Streptococcus gordonii and Streptococcus sanguinis Revealed by Comparative Genome Analysis. Scientific Reports, 7 (1). pp. 1-16. ISSN 2045-2322 https://www.nature.com/articles/s41598-017-02399-4 DOI: 10.1038/s41598-017-02399-4
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic RK Dentistry
spellingShingle RK Dentistry
Zheng, W.
Tan, M.F.
Old, L.A.
Paterson, I.C.
Jakubovics, N.S.
Choo, S.W.
Distinct Biological Potential of Streptococcus gordonii and Streptococcus sanguinis Revealed by Comparative Genome Analysis
description Streptococcus gordonii and Streptococcus sanguinis are pioneer colonizers of dental plaque and important agents of bacterial infective endocarditis (IE). To gain a greater understanding of these two closely related species, we performed comparative analyses on 14 new S. gordonii and 5 S. sanguinis strains using various bioinformatics approaches. We revealed S. gordonii and S. sanguinis harbor open pan-genomes and share generally high sequence homology and number of core genes including virulence genes. However, we observed subtle differences in genomic islands and prophages between the species. Comparative pathogenomics analysis identified S. sanguinis strains have genes encoding IgA proteases, mitogenic factor deoxyribonucleases, nickel/cobalt uptake and cobalamin biosynthesis. On the contrary, genomic islands of S. gordonii strains contain additional copies of comCDE quorum-sensing system components involved in genetic competence. Two distinct polysaccharide locus architectures were identified, one of which was exclusively present in S. gordonii strains. The first evidence of genes encoding the CylA and CylB system by the α-haemolytic S. gordonii is presented. This study provides new insights into the genetic distinctions between S. gordonii and S. sanguinis, which yields understanding of tooth surfaces colonization and contributions to dental plaque formation, as well as their potential roles in the pathogenesis of IE.
format Article
author Zheng, W.
Tan, M.F.
Old, L.A.
Paterson, I.C.
Jakubovics, N.S.
Choo, S.W.
author_facet Zheng, W.
Tan, M.F.
Old, L.A.
Paterson, I.C.
Jakubovics, N.S.
Choo, S.W.
author_sort Zheng, W.
title Distinct Biological Potential of Streptococcus gordonii and Streptococcus sanguinis Revealed by Comparative Genome Analysis
title_short Distinct Biological Potential of Streptococcus gordonii and Streptococcus sanguinis Revealed by Comparative Genome Analysis
title_full Distinct Biological Potential of Streptococcus gordonii and Streptococcus sanguinis Revealed by Comparative Genome Analysis
title_fullStr Distinct Biological Potential of Streptococcus gordonii and Streptococcus sanguinis Revealed by Comparative Genome Analysis
title_full_unstemmed Distinct Biological Potential of Streptococcus gordonii and Streptococcus sanguinis Revealed by Comparative Genome Analysis
title_sort distinct biological potential of streptococcus gordonii and streptococcus sanguinis revealed by comparative genome analysis
publisher Nature Publishing Group
publishDate 2017
url http://eprints.um.edu.my/17537/1/ZhengW_%282017%29.pdf
http://eprints.um.edu.my/17537/
https://www.nature.com/articles/s41598-017-02399-4
_version_ 1643690446088568832
score 13.211869

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