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Patterns of breast cancer relapse at University of Malaya Medical Centre

Despite being the major cause of cancer-related death in Malaysian women,local data on patterns of breast cancer relapse and their long term outcomes are still scarce. We conducted a retrospective study on all patients treated for non-metastatic invasive breast cancer in 1999-2000 at the University...

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Main Authors:	Rozita, A.M., Marniza, S., Mastura, M.Y., Wan Zamaniah, W.I., Yip, C.H., Taib, N.A.
Format:	Article
Published:	2010
Subjects:	RD Surgery
Online Access:	http://eprints.um.edu.my/1700/ http://myais.fsktm.um.edu.my/11434/
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spelling	my.um.eprints.17002014-12-12T01:40:28Z http://eprints.um.edu.my/1700/ Patterns of breast cancer relapse at University of Malaya Medical Centre Rozita, A.M. Marniza, S. Mastura, M.Y. Wan Zamaniah, W.I. Yip, C.H. Taib, N.A. RD Surgery Despite being the major cause of cancer-related death in Malaysian women,local data on patterns of breast cancer relapse and their long term outcomes are still scarce. We conducted a retrospective study on all patients treated for non-metastatic invasive breast cancer in 1999-2000 at the University of Malaya Medical Centre (UMMC), who subsequently developed relapse. We sought to analyse the patterns of relapse, their associated clinicopathological features and the overall survival ratefollowing the relapses. Univariate and multivariate analyses were used to analyse demographics and clinicopathological factors. Survival was analysed using the Kaplan and Meier method and compared by the log rank test. A total of 268 patients with a mean age of 50, were identified for the study. At a median follow-up of 50 months, 73 patients (27.2%) had relapsed. Local, regional and distant relapse rates were 5.5%, 1.9% and 19.8% respectively, whereas, the 5-year survival rates were 61%, 40% and 21% respectively (p < 0.01). Most relapses occurred within the first five years of diagnosis. Patients with long disease-free interval had better survival. The most common distant relapse site was the lungs while bone was the distant relapse site with the best prognosis. Disease stage, nodal status and oestrogen receptor status were found to have correlation with the risk of relapse. We concluded that the survival of patients with relapsed breast cancer was associated with the site(s) of first relapse and the disease free interval and clinicopathological factors can be used to predict the risk of relapse. 2010 Article PeerReviewed Rozita, A.M. and Marniza, S. and Mastura, M.Y. and Wan Zamaniah, W.I. and Yip, C.H. and Taib, N.A. (2010) Patterns of breast cancer relapse at University of Malaya Medical Centre. Journal of the University of Malaya Medical Centre (JUMMEC), 13 (1). pp. 24-32. ISSN 1823-7339 http://myais.fsktm.um.edu.my/11434/ 11434
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	RD Surgery
spellingShingle	RD Surgery Rozita, A.M. Marniza, S. Mastura, M.Y. Wan Zamaniah, W.I. Yip, C.H. Taib, N.A. Patterns of breast cancer relapse at University of Malaya Medical Centre
description	Despite being the major cause of cancer-related death in Malaysian women,local data on patterns of breast cancer relapse and their long term outcomes are still scarce. We conducted a retrospective study on all patients treated for non-metastatic invasive breast cancer in 1999-2000 at the University of Malaya Medical Centre (UMMC), who subsequently developed relapse. We sought to analyse the patterns of relapse, their associated clinicopathological features and the overall survival ratefollowing the relapses. Univariate and multivariate analyses were used to analyse demographics and clinicopathological factors. Survival was analysed using the Kaplan and Meier method and compared by the log rank test. A total of 268 patients with a mean age of 50, were identified for the study. At a median follow-up of 50 months, 73 patients (27.2%) had relapsed. Local, regional and distant relapse rates were 5.5%, 1.9% and 19.8% respectively, whereas, the 5-year survival rates were 61%, 40% and 21% respectively (p < 0.01). Most relapses occurred within the first five years of diagnosis. Patients with long disease-free interval had better survival. The most common distant relapse site was the lungs while bone was the distant relapse site with the best prognosis. Disease stage, nodal status and oestrogen receptor status were found to have correlation with the risk of relapse. We concluded that the survival of patients with relapsed breast cancer was associated with the site(s) of first relapse and the disease free interval and clinicopathological factors can be used to predict the risk of relapse.
format	Article
author	Rozita, A.M. Marniza, S. Mastura, M.Y. Wan Zamaniah, W.I. Yip, C.H. Taib, N.A.
author_facet	Rozita, A.M. Marniza, S. Mastura, M.Y. Wan Zamaniah, W.I. Yip, C.H. Taib, N.A.
author_sort	Rozita, A.M.
title	Patterns of breast cancer relapse at University of Malaya Medical Centre
title_short	Patterns of breast cancer relapse at University of Malaya Medical Centre
title_full	Patterns of breast cancer relapse at University of Malaya Medical Centre
title_fullStr	Patterns of breast cancer relapse at University of Malaya Medical Centre
title_full_unstemmed	Patterns of breast cancer relapse at University of Malaya Medical Centre
title_sort	patterns of breast cancer relapse at university of malaya medical centre
publishDate	2010
url	http://eprints.um.edu.my/1700/ http://myais.fsktm.um.edu.my/11434/
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score	13.211869

Patterns of breast cancer relapse at University of Malaya Medical Centre

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