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Effect of microbial cell preparation on renal profile and liver function among type 2 diabetics: a randomized controlled trial

Background: The beneficial effect of probiotics on renal profile and liver function has been reported among patients with chronic kidney disease and fatty liver respectively. However, its effect on renal profile and liver function among type 2 diabetic individuals has not been fully understood. To i...

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Main Authors: Firouzi, Somayyeh, Mohd-Yusof, Barakatun-Nisak, Majid, Hazreen Abdul, Ismail, Amin, Kamaruddin, Nor Azmi
Format: Article
Published: BMC 2015
Subjects:
R Medicine (General)
Online Access:http://eprints.um.edu.my/16196/
https://doi.org/10.1186/s12906-015-0952-5
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spelling my.um.eprints.161962019-12-16T09:19:20Z http://eprints.um.edu.my/16196/ Effect of microbial cell preparation on renal profile and liver function among type 2 diabetics: a randomized controlled trial Firouzi, Somayyeh Mohd-Yusof, Barakatun-Nisak Majid, Hazreen Abdul Ismail, Amin Kamaruddin, Nor Azmi R Medicine (General) Background: The beneficial effect of probiotics on renal profile and liver function has been reported among patients with chronic kidney disease and fatty liver respectively. However, its effect on renal profile and liver function among type 2 diabetic individuals has not been fully understood. To investigate the effect of microbial cell preparation on renal profile and liver function tests among type 2 diabetic individuals. Methods: A randomized, double-blind, parallel-group, controlled clinical trial was conducted on a total of 136 type 2 diabetics age 30-70 years old in a teaching hospital in Kuala Lumpur, Malaysia. Subjects were randomly assigned to receive microbial cell preparation (N = 68) or a placebo (N = 68) for 12 weeks. The outcomes measured at baseline, week 6, and week 12 and included changes in renal profile (Sodium, Potassium, Urea, Creatinine, Glomerular Filtration Rate), and liver function tests (Albumin, Total Protein, Alkaline Phosphatase, Alanine Aminotransferase, Aspartate Aminotransferase). Intention to treat (ITT) analysis was performed on all the recruited subjects, while per protocol (PP) analysis was conducted on those who completed the trial with good compliance. Result: The urea levels significantly declined in the probiotic group. Serum urea levels reduced from 4.26 mmol/L to 4.04 mmol/L in Probiotic Group while it increased in Placebo Group from 4.03 mmol/L to 4.24 mmol/L. These changes were significant between groups in ITT analysis (p = 0.018). Other parameters did not change significantly between groups. Conclusion: 12 weeks supplementation with daily dosage of 6 x 10(10) Colony Forming Units of multi-strain microbial cell preparation significantly improved urea levels. BMC 2015 Article PeerReviewed Firouzi, Somayyeh and Mohd-Yusof, Barakatun-Nisak and Majid, Hazreen Abdul and Ismail, Amin and Kamaruddin, Nor Azmi (2015) Effect of microbial cell preparation on renal profile and liver function among type 2 diabetics: a randomized controlled trial. BMC Complementary and Alternative Medicine, 15. p. 433. ISSN 1472-6882 https://doi.org/10.1186/s12906-015-0952-5 doi:10.1186/s12906-015-0952-5
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine (General)
spellingShingle R Medicine (General)
Firouzi, Somayyeh
Mohd-Yusof, Barakatun-Nisak
Majid, Hazreen Abdul
Ismail, Amin
Kamaruddin, Nor Azmi
Effect of microbial cell preparation on renal profile and liver function among type 2 diabetics: a randomized controlled trial
description Background: The beneficial effect of probiotics on renal profile and liver function has been reported among patients with chronic kidney disease and fatty liver respectively. However, its effect on renal profile and liver function among type 2 diabetic individuals has not been fully understood. To investigate the effect of microbial cell preparation on renal profile and liver function tests among type 2 diabetic individuals. Methods: A randomized, double-blind, parallel-group, controlled clinical trial was conducted on a total of 136 type 2 diabetics age 30-70 years old in a teaching hospital in Kuala Lumpur, Malaysia. Subjects were randomly assigned to receive microbial cell preparation (N = 68) or a placebo (N = 68) for 12 weeks. The outcomes measured at baseline, week 6, and week 12 and included changes in renal profile (Sodium, Potassium, Urea, Creatinine, Glomerular Filtration Rate), and liver function tests (Albumin, Total Protein, Alkaline Phosphatase, Alanine Aminotransferase, Aspartate Aminotransferase). Intention to treat (ITT) analysis was performed on all the recruited subjects, while per protocol (PP) analysis was conducted on those who completed the trial with good compliance. Result: The urea levels significantly declined in the probiotic group. Serum urea levels reduced from 4.26 mmol/L to 4.04 mmol/L in Probiotic Group while it increased in Placebo Group from 4.03 mmol/L to 4.24 mmol/L. These changes were significant between groups in ITT analysis (p = 0.018). Other parameters did not change significantly between groups. Conclusion: 12 weeks supplementation with daily dosage of 6 x 10(10) Colony Forming Units of multi-strain microbial cell preparation significantly improved urea levels.
format Article
author Firouzi, Somayyeh
Mohd-Yusof, Barakatun-Nisak
Majid, Hazreen Abdul
Ismail, Amin
Kamaruddin, Nor Azmi
author_facet Firouzi, Somayyeh
Mohd-Yusof, Barakatun-Nisak
Majid, Hazreen Abdul
Ismail, Amin
Kamaruddin, Nor Azmi
author_sort Firouzi, Somayyeh
title Effect of microbial cell preparation on renal profile and liver function among type 2 diabetics: a randomized controlled trial
title_short Effect of microbial cell preparation on renal profile and liver function among type 2 diabetics: a randomized controlled trial
title_full Effect of microbial cell preparation on renal profile and liver function among type 2 diabetics: a randomized controlled trial
title_fullStr Effect of microbial cell preparation on renal profile and liver function among type 2 diabetics: a randomized controlled trial
title_full_unstemmed Effect of microbial cell preparation on renal profile and liver function among type 2 diabetics: a randomized controlled trial
title_sort effect of microbial cell preparation on renal profile and liver function among type 2 diabetics: a randomized controlled trial
publisher BMC
publishDate 2015
url http://eprints.um.edu.my/16196/
https://doi.org/10.1186/s12906-015-0952-5
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score 13.211869

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