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Electrospun biopolyesters as drug screening platforms for corneal keratocytes

In vitro drug screening techniques provide rapid and easy to analyze data, while saving a lot of animals from being sacrificed. An important part of any in vitro drug screening platform is a biomaterial which promotes cell growth and proliferation. The potential of electrospun scaffolds made of poly...

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Main Authors: Azari, P., Luan, N.S., Gan, S.N., Yahya, R., Wong, C.S., Chua, K.H., Pingguan-Murphy, Belinda
Format: Article
Language:English
Published: 2015
Subjects:
T Technology (General)
TA Engineering (General). Civil engineering (General)
Online Access:http://eprints.um.edu.my/15740/1/Electrospun_Biopolyesters_as_Drug_Screening_Platforms_for_Corneal_Keratocytes.pdf
http://eprints.um.edu.my/15740/
http://www.tandfonline.com/doi/pdf/10.1080/00914037.2015.1030648
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spelling my.um.eprints.157402020-02-10T08:37:48Z http://eprints.um.edu.my/15740/ Electrospun biopolyesters as drug screening platforms for corneal keratocytes Azari, P. Luan, N.S. Gan, S.N. Yahya, R. Wong, C.S. Chua, K.H. Pingguan-Murphy, Belinda T Technology (General) TA Engineering (General). Civil engineering (General) In vitro drug screening techniques provide rapid and easy to analyze data, while saving a lot of animals from being sacrificed. An important part of any in vitro drug screening platform is a biomaterial which promotes cell growth and proliferation. The potential of electrospun scaffolds made of polyhydroxybutyrate (PHB), poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV), and polycaprolactone (PCL) were studied to serve as drug screening platform for corneal keratocyte tissues. The results showed that the proliferation rate was slightly higher for PCL and PHBV on day 7. Gene expression results showed that PCL was the best in maintaining keratocyte genes. GRAPHICS . 2015 Article PeerReviewed application/pdf en http://eprints.um.edu.my/15740/1/Electrospun_Biopolyesters_as_Drug_Screening_Platforms_for_Corneal_Keratocytes.pdf Azari, P. and Luan, N.S. and Gan, S.N. and Yahya, R. and Wong, C.S. and Chua, K.H. and Pingguan-Murphy, Belinda (2015) Electrospun biopolyesters as drug screening platforms for corneal keratocytes. International Journal of Polymeric Materials and Polymeric Biomaterials, 64 (15). pp. 785-791. ISSN 0091-4037 http://www.tandfonline.com/doi/pdf/10.1080/00914037.2015.1030648 10.1080/00914037.2015.1030648
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic T Technology (General)
TA Engineering (General). Civil engineering (General)
spellingShingle T Technology (General)
TA Engineering (General). Civil engineering (General)
Azari, P.
Luan, N.S.
Gan, S.N.
Yahya, R.
Wong, C.S.
Chua, K.H.
Pingguan-Murphy, Belinda
Electrospun biopolyesters as drug screening platforms for corneal keratocytes
description In vitro drug screening techniques provide rapid and easy to analyze data, while saving a lot of animals from being sacrificed. An important part of any in vitro drug screening platform is a biomaterial which promotes cell growth and proliferation. The potential of electrospun scaffolds made of polyhydroxybutyrate (PHB), poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV), and polycaprolactone (PCL) were studied to serve as drug screening platform for corneal keratocyte tissues. The results showed that the proliferation rate was slightly higher for PCL and PHBV on day 7. Gene expression results showed that PCL was the best in maintaining keratocyte genes. GRAPHICS .
format Article
author Azari, P.
Luan, N.S.
Gan, S.N.
Yahya, R.
Wong, C.S.
Chua, K.H.
Pingguan-Murphy, Belinda
author_facet Azari, P.
Luan, N.S.
Gan, S.N.
Yahya, R.
Wong, C.S.
Chua, K.H.
Pingguan-Murphy, Belinda
author_sort Azari, P.
title Electrospun biopolyesters as drug screening platforms for corneal keratocytes
title_short Electrospun biopolyesters as drug screening platforms for corneal keratocytes
title_full Electrospun biopolyesters as drug screening platforms for corneal keratocytes
title_fullStr Electrospun biopolyesters as drug screening platforms for corneal keratocytes
title_full_unstemmed Electrospun biopolyesters as drug screening platforms for corneal keratocytes
title_sort electrospun biopolyesters as drug screening platforms for corneal keratocytes
publishDate 2015
url http://eprints.um.edu.my/15740/1/Electrospun_Biopolyesters_as_Drug_Screening_Platforms_for_Corneal_Keratocytes.pdf
http://eprints.um.edu.my/15740/
http://www.tandfonline.com/doi/pdf/10.1080/00914037.2015.1030648
_version_ 1662755142417514496
score 13.211869

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