Cover Image

Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking

We demonstrate the in vivo assessment of human scars by parametric imaging of birefringence using polarization-sensitive optical coherence tomography (PS-OCT). Such in vivo assessment is subject to artifacts in the detected birefringence caused by scattering from blood vessels. To reduce these artif...

Full description

Saved in:
Bibliographic Details
Main Authors: Gong, P., Chin, L., Es'haghian, S., Liew, Y.M., Wood, F.M., Sampson, D.D., McLaughlin, R.A.
Format: Article
Published: International Society for Optical Engineering (SPIE) 2014
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/15543/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.um.eprints.15543
record_format eprints
spelling my.um.eprints.155432016-01-22T01:56:34Z http://eprints.um.edu.my/15543/ Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking Gong, P. Chin, L. Es'haghian, S. Liew, Y.M. Wood, F.M. Sampson, D.D. McLaughlin, R.A. R Medicine We demonstrate the in vivo assessment of human scars by parametric imaging of birefringence using polarization-sensitive optical coherence tomography (PS-OCT). Such in vivo assessment is subject to artifacts in the detected birefringence caused by scattering from blood vessels. To reduce these artifacts, we preprocessed the PS-OCT data using a vascular masking technique. The birefringence of the remaining tissue regions was then automatically quantified. Results from the scars and contralateral or adjacent normal skin of 13 patients show a correspondence of birefringence with scar type: the ratio of birefringence of hypertrophic scars to corresponding normal skin is 2.2 +/- 0.2 (mean +/- standard deviation), while the ratio of birefringence of normotrophic scars to normal skin is 1.1 +/- 0.4. This method represents a new clinically applicable means for objective, quantitative human scar assessment. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE) International Society for Optical Engineering (SPIE) 2014 Article PeerReviewed Gong, P. and Chin, L. and Es'haghian, S. and Liew, Y.M. and Wood, F.M. and Sampson, D.D. and McLaughlin, R.A. (2014) Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking. Journal of Biomedical Optics (JBO), 19 (12).
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Gong, P.
Chin, L.
Es'haghian, S.
Liew, Y.M.
Wood, F.M.
Sampson, D.D.
McLaughlin, R.A.
Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking
description We demonstrate the in vivo assessment of human scars by parametric imaging of birefringence using polarization-sensitive optical coherence tomography (PS-OCT). Such in vivo assessment is subject to artifacts in the detected birefringence caused by scattering from blood vessels. To reduce these artifacts, we preprocessed the PS-OCT data using a vascular masking technique. The birefringence of the remaining tissue regions was then automatically quantified. Results from the scars and contralateral or adjacent normal skin of 13 patients show a correspondence of birefringence with scar type: the ratio of birefringence of hypertrophic scars to corresponding normal skin is 2.2 +/- 0.2 (mean +/- standard deviation), while the ratio of birefringence of normotrophic scars to normal skin is 1.1 +/- 0.4. This method represents a new clinically applicable means for objective, quantitative human scar assessment. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
format Article
author Gong, P.
Chin, L.
Es'haghian, S.
Liew, Y.M.
Wood, F.M.
Sampson, D.D.
McLaughlin, R.A.
author_facet Gong, P.
Chin, L.
Es'haghian, S.
Liew, Y.M.
Wood, F.M.
Sampson, D.D.
McLaughlin, R.A.
author_sort Gong, P.
title Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking
title_short Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking
title_full Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking
title_fullStr Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking
title_full_unstemmed Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking
title_sort imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking
publisher International Society for Optical Engineering (SPIE)
publishDate 2014
url http://eprints.um.edu.my/15543/
_version_ 1643690078168416256
score 13.244745

Similar Items