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Current aspects in hemoglobin A1c detection: A review

Type 2 diabetes mellitus (T2DM) is a pressing health issue that threatens global health and the productivity of populations worldwide. Despite its long-recognized role in diabetes management, glycated hemoglobin (HbA1c) only received WHO endorsement as a T2DM diagnostic tool in 2011. Although conven...

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Main Authors: Ang, S.H., Thevarajah, M., Alias, Y., Khor, S.M.
Format: Article
Language:English
Published: Elsevier 2015
Subjects:
QD Chemistry
Online Access:http://eprints.um.edu.my/15511/1/Clinica_Chimica_Acta_439_%282015%29_202%E2%80%93211_%28post-print_version%29.pdf
http://eprints.um.edu.my/15511/
http://www.sciencedirect.com/science/article/pii/S0009898114004501 http://ac.els-cdn.com/S0009898114004501/1-s2.0-S0009898114004501-main.pdf?tid=88fe4552-a7a2-11e5-853c-00000aacb35e&acdnat=14506754032a82a215fbe5aceba4c72943119add86
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spelling my.um.eprints.155112016-01-12T02:12:34Z http://eprints.um.edu.my/15511/ Current aspects in hemoglobin A1c detection: A review Ang, S.H. Thevarajah, M. Alias, Y. Khor, S.M. QD Chemistry Type 2 diabetes mellitus (T2DM) is a pressing health issue that threatens global health and the productivity of populations worldwide. Despite its long-recognized role in diabetes management, glycated hemoglobin (HbA1c) only received WHO endorsement as a T2DM diagnostic tool in 2011. Although conventional plasma-specific tests have long been utilized to diagnose T2DM, the public should be informed that plasma-specific tests are not markedly better than HbA1c tests, particularly in terms of variability and convenience for diagnosing diabetes. In the midst of the debates associated with establishing HbA1c as the preeminent diabetes diagnostic tool, unceasing efforts to standardize HbA1c tests have played an integral part in achieving more efficient communication from laboratory to clinical practice and thus better diabetes care. This review discusses the current status of HbA1c tests in the diagnosis, prevention, treatment and management of T2DM across the globe, focusing on increasing the recognition of glycated hemoglobin variants with effective utilization of different HbA1c methods, updating the current status of HbA1c standardization programs, tapping into the potential of POC analyzers to establish a cost-effective HbA1c test for diabetes care, and inspiring the advancement of HbA1c biosensors for future clinical usage. Elsevier 2015 Article PeerReviewed application/pdf en http://eprints.um.edu.my/15511/1/Clinica_Chimica_Acta_439_%282015%29_202%E2%80%93211_%28post-print_version%29.pdf Ang, S.H. and Thevarajah, M. and Alias, Y. and Khor, S.M. (2015) Current aspects in hemoglobin A1c detection: A review. Clinica Chimica Acta, 439. pp. 202-211. http://www.sciencedirect.com/science/article/pii/S0009898114004501 http://ac.els-cdn.com/S0009898114004501/1-s2.0-S0009898114004501-main.pdf?tid=88fe4552-a7a2-11e5-853c-00000aacb35e&acdnat=14506754032a82a215fbe5aceba4c72943119add86
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Ang, S.H.
Thevarajah, M.
Alias, Y.
Khor, S.M.
Current aspects in hemoglobin A1c detection: A review
description Type 2 diabetes mellitus (T2DM) is a pressing health issue that threatens global health and the productivity of populations worldwide. Despite its long-recognized role in diabetes management, glycated hemoglobin (HbA1c) only received WHO endorsement as a T2DM diagnostic tool in 2011. Although conventional plasma-specific tests have long been utilized to diagnose T2DM, the public should be informed that plasma-specific tests are not markedly better than HbA1c tests, particularly in terms of variability and convenience for diagnosing diabetes. In the midst of the debates associated with establishing HbA1c as the preeminent diabetes diagnostic tool, unceasing efforts to standardize HbA1c tests have played an integral part in achieving more efficient communication from laboratory to clinical practice and thus better diabetes care. This review discusses the current status of HbA1c tests in the diagnosis, prevention, treatment and management of T2DM across the globe, focusing on increasing the recognition of glycated hemoglobin variants with effective utilization of different HbA1c methods, updating the current status of HbA1c standardization programs, tapping into the potential of POC analyzers to establish a cost-effective HbA1c test for diabetes care, and inspiring the advancement of HbA1c biosensors for future clinical usage.
format Article
author Ang, S.H.
Thevarajah, M.
Alias, Y.
Khor, S.M.
author_facet Ang, S.H.
Thevarajah, M.
Alias, Y.
Khor, S.M.
author_sort Ang, S.H.
title Current aspects in hemoglobin A1c detection: A review
title_short Current aspects in hemoglobin A1c detection: A review
title_full Current aspects in hemoglobin A1c detection: A review
title_fullStr Current aspects in hemoglobin A1c detection: A review
title_full_unstemmed Current aspects in hemoglobin A1c detection: A review
title_sort current aspects in hemoglobin a1c detection: a review
publisher Elsevier
publishDate 2015
url http://eprints.um.edu.my/15511/1/Clinica_Chimica_Acta_439_%282015%29_202%E2%80%93211_%28post-print_version%29.pdf
http://eprints.um.edu.my/15511/
http://www.sciencedirect.com/science/article/pii/S0009898114004501 http://ac.els-cdn.com/S0009898114004501/1-s2.0-S0009898114004501-main.pdf?tid=88fe4552-a7a2-11e5-853c-00000aacb35e&acdnat=14506754032a82a215fbe5aceba4c72943119add86
_version_ 1643690070821044224
score 13.211869

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