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Does the cranial suspensory ligament have a role in cryptorchidism?

The cranial suspensory ligament (CSL) is a fibromuscular structure anchoring the embryonic gonad to the posterior abdominal wall in male and female mammals. Its persistence in females is believed to be responsible for retaining the ovaries within the abdomen, while its regression in males permits te...

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Main Authors: Kassim, N.M., Russell, D.A., Payne, A.P.
Format: Article
Published: Karger Publishers 2010
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/15353/
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spelling my.um.eprints.153532015-12-28T08:42:28Z http://eprints.um.edu.my/15353/ Does the cranial suspensory ligament have a role in cryptorchidism? Kassim, N.M. Russell, D.A. Payne, A.P. R Medicine The cranial suspensory ligament (CSL) is a fibromuscular structure anchoring the embryonic gonad to the posterior abdominal wall in male and female mammals. Its persistence in females is believed to be responsible for retaining the ovaries within the abdomen, while its regression in males permits testis descent. Embryonic loss of the CSL in males is believed to be an androgen-dependent event, and failure of this process has been proposed as a cause of cryptorchidism. The present study demonstrates that the nuclei of mesenchymal cells in the caudal part of the CSL are immunoreactively positive for androgen receptor. We examined the effects of exposure of the non-steroidal antiandrogen flutamide during the period from gestational day 10 to birth on the development of the CSL and on testis descent. Exposure of male Albino Swiss rats to the antiandrogen flutamide during this period resulted in feminization of the external genitalia and the suppression of growth of the testes and male reproductive tracts. In adulthood, testes were found to be located in diverse positions including normal scrotal (50%), intra-abdominal (10%) and ectopic suprainguinal (40%). The CSL of the testis persisted into adulthood in all flutamidetreated males, regardless of testis location. In all cases, the ligament consisted of bundles of smooth muscle fibres in the retroperitoneal fat of the posterior abdominal wall. These findings suggest that androgen blockade during embryonic development interferes with testicular descent, but that maldescent cannot be correlated with either the persistence of the CSL of the testis or its structure. Copyright (C) 2009 S. Karger AG, Basel Karger Publishers 2010 Article PeerReviewed Kassim, N.M. and Russell, D.A. and Payne, A.P. (2010) Does the cranial suspensory ligament have a role in cryptorchidism? Cells Tissues Organs, 191 (4). pp. 307-315.
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Kassim, N.M.
Russell, D.A.
Payne, A.P.
Does the cranial suspensory ligament have a role in cryptorchidism?
description The cranial suspensory ligament (CSL) is a fibromuscular structure anchoring the embryonic gonad to the posterior abdominal wall in male and female mammals. Its persistence in females is believed to be responsible for retaining the ovaries within the abdomen, while its regression in males permits testis descent. Embryonic loss of the CSL in males is believed to be an androgen-dependent event, and failure of this process has been proposed as a cause of cryptorchidism. The present study demonstrates that the nuclei of mesenchymal cells in the caudal part of the CSL are immunoreactively positive for androgen receptor. We examined the effects of exposure of the non-steroidal antiandrogen flutamide during the period from gestational day 10 to birth on the development of the CSL and on testis descent. Exposure of male Albino Swiss rats to the antiandrogen flutamide during this period resulted in feminization of the external genitalia and the suppression of growth of the testes and male reproductive tracts. In adulthood, testes were found to be located in diverse positions including normal scrotal (50%), intra-abdominal (10%) and ectopic suprainguinal (40%). The CSL of the testis persisted into adulthood in all flutamidetreated males, regardless of testis location. In all cases, the ligament consisted of bundles of smooth muscle fibres in the retroperitoneal fat of the posterior abdominal wall. These findings suggest that androgen blockade during embryonic development interferes with testicular descent, but that maldescent cannot be correlated with either the persistence of the CSL of the testis or its structure. Copyright (C) 2009 S. Karger AG, Basel
format Article
author Kassim, N.M.
Russell, D.A.
Payne, A.P.
author_facet Kassim, N.M.
Russell, D.A.
Payne, A.P.
author_sort Kassim, N.M.
title Does the cranial suspensory ligament have a role in cryptorchidism?
title_short Does the cranial suspensory ligament have a role in cryptorchidism?
title_full Does the cranial suspensory ligament have a role in cryptorchidism?
title_fullStr Does the cranial suspensory ligament have a role in cryptorchidism?
title_full_unstemmed Does the cranial suspensory ligament have a role in cryptorchidism?
title_sort does the cranial suspensory ligament have a role in cryptorchidism?
publisher Karger Publishers
publishDate 2010
url http://eprints.um.edu.my/15353/
_version_ 1643690036472840192
score 13.211869

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