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The accuracy of pharmacokinetic parameter measurement in DCE-MRI of the breast at 3 T

The purpose of this work is to quantify the accuracy of pharmacokinetic parameter measurement in DCE-MRI of breast cancer at 3 T in relation to three sources of error. Individually, T1 measurement error, temporal resolution and transmitted RF field inhomogeneity are considered. Dynamic contrast enha...

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Main Authors: Di Giovanni, P., Azlan, C.A., Ahearn, T.S., Semple, S.I., Gilbert, F.J., Redpath, T.W.
Format: Article
Published: IOP Publishing 2010
Subjects:
QC Physics
Online Access:http://eprints.um.edu.my/15271/
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spelling my.um.eprints.152712020-01-03T04:19:57Z http://eprints.um.edu.my/15271/ The accuracy of pharmacokinetic parameter measurement in DCE-MRI of the breast at 3 T Di Giovanni, P. Azlan, C.A. Ahearn, T.S. Semple, S.I. Gilbert, F.J. Redpath, T.W. QC Physics The purpose of this work is to quantify the accuracy of pharmacokinetic parameter measurement in DCE-MRI of breast cancer at 3 T in relation to three sources of error. Individually, T1 measurement error, temporal resolution and transmitted RF field inhomogeneity are considered. Dynamic contrast enhancement curves were simulated using standard acquisition parameters of a DCE-MRI protocol. Errors on pre-contrast T1 due to incorrect RF spoiling were considered. Flip angle errors were measured and introduced into the fitting routine, and temporal resolution was also varied. The error in fitted pharmacokinetic parameters, K(trans) and v(e), was calculated. Flip angles were found to be reduced by up to 55% of the expected value. The resultant errors in our range of K(trans) and v(e) were found to be up to 66% and 74%, respectively. Incorrect T1 estimation results in K(trans) and v(e) errors up to 531% and 233%, respectively. When the temporal resolution is reduced from 10 to 70 s K(trans) drops by up to 48%, while v(e) shows negligible variation. In combination, uncertainties in tissue T1 map and applied flip angle were shown to contribute to errors of up to 88% in K(trans) and 73% in v(e). These results demonstrate the importance of high temporal resolution, accurate T1 measurement and good B1 homogeneity. IOP Publishing 2010 Article PeerReviewed Di Giovanni, P. and Azlan, C.A. and Ahearn, T.S. and Semple, S.I. and Gilbert, F.J. and Redpath, T.W. (2010) The accuracy of pharmacokinetic parameter measurement in DCE-MRI of the breast at 3 T. Physics in Medicine & Biology, 55 (1). pp. 121-132. ISSN 0031-9155
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QC Physics
spellingShingle QC Physics
Di Giovanni, P.
Azlan, C.A.
Ahearn, T.S.
Semple, S.I.
Gilbert, F.J.
Redpath, T.W.
The accuracy of pharmacokinetic parameter measurement in DCE-MRI of the breast at 3 T
description The purpose of this work is to quantify the accuracy of pharmacokinetic parameter measurement in DCE-MRI of breast cancer at 3 T in relation to three sources of error. Individually, T1 measurement error, temporal resolution and transmitted RF field inhomogeneity are considered. Dynamic contrast enhancement curves were simulated using standard acquisition parameters of a DCE-MRI protocol. Errors on pre-contrast T1 due to incorrect RF spoiling were considered. Flip angle errors were measured and introduced into the fitting routine, and temporal resolution was also varied. The error in fitted pharmacokinetic parameters, K(trans) and v(e), was calculated. Flip angles were found to be reduced by up to 55% of the expected value. The resultant errors in our range of K(trans) and v(e) were found to be up to 66% and 74%, respectively. Incorrect T1 estimation results in K(trans) and v(e) errors up to 531% and 233%, respectively. When the temporal resolution is reduced from 10 to 70 s K(trans) drops by up to 48%, while v(e) shows negligible variation. In combination, uncertainties in tissue T1 map and applied flip angle were shown to contribute to errors of up to 88% in K(trans) and 73% in v(e). These results demonstrate the importance of high temporal resolution, accurate T1 measurement and good B1 homogeneity.
format Article
author Di Giovanni, P.
Azlan, C.A.
Ahearn, T.S.
Semple, S.I.
Gilbert, F.J.
Redpath, T.W.
author_facet Di Giovanni, P.
Azlan, C.A.
Ahearn, T.S.
Semple, S.I.
Gilbert, F.J.
Redpath, T.W.
author_sort Di Giovanni, P.
title The accuracy of pharmacokinetic parameter measurement in DCE-MRI of the breast at 3 T
title_short The accuracy of pharmacokinetic parameter measurement in DCE-MRI of the breast at 3 T
title_full The accuracy of pharmacokinetic parameter measurement in DCE-MRI of the breast at 3 T
title_fullStr The accuracy of pharmacokinetic parameter measurement in DCE-MRI of the breast at 3 T
title_full_unstemmed The accuracy of pharmacokinetic parameter measurement in DCE-MRI of the breast at 3 T
title_sort accuracy of pharmacokinetic parameter measurement in dce-mri of the breast at 3 t
publisher IOP Publishing
publishDate 2010
url http://eprints.um.edu.my/15271/
_version_ 1654960666230915072
score 13.211869

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