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Molecular analysis of HLA Class I and Class II genes in four indigenous Malaysian populations

This is the first report of high-resolution human leukocyte antigen (HLA) typing in four indigenous groups in Malaysia. A total of 99 normal, healthy participants representing the Negrito (Jehai and Kensiu), Proto-Malay (Temuan) and a native group of Borneo (Bidayuh) were typed for HLA-A, -B, -DRB1...

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Main Authors: Jinam, T.A., Saitou, N., Edo, J., Mahmood, A., Phipps, M.E.
Format: Article
Published: Blackwell Publishing 2010
Subjects:
Q Science (General)
Online Access:http://eprints.um.edu.my/15261/
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spelling my.um.eprints.152612015-12-23T03:08:06Z http://eprints.um.edu.my/15261/ Molecular analysis of HLA Class I and Class II genes in four indigenous Malaysian populations Jinam, T.A. Saitou, N. Edo, J. Mahmood, A. Phipps, M.E. Q Science (General) This is the first report of high-resolution human leukocyte antigen (HLA) typing in four indigenous groups in Malaysia. A total of 99 normal, healthy participants representing the Negrito (Jehai and Kensiu), Proto-Malay (Temuan) and a native group of Borneo (Bidayuh) were typed for HLA-A, -B, -DRB1 and -DQB1 genes using sequence-based typing. Eleven HLA-A, 26 HLA-B, 16 HLA-DRB1 and 14 HLA-DQB1 alleles were detected, including a new allele, HLA-B*3589 in the Jehai. Highly frequent alleles were A*2407, B*1513, B*1801, DRB1*0901, DRB1*1202, DRB1*1502, DQB1*0303 and DQB1*0502. Principal component analysis based on high-resolution HLA-A, -B and -DRB1 allele frequencies showed close affinities among all four groups, including the Negritos, with other Southeast Asian populations. These results showed the scope of HLA diversity in these indigenous minority groups and may prove beneficial for future disease association, anthropological and forensic studies. Blackwell Publishing 2010 Article PeerReviewed Jinam, T.A. and Saitou, N. and Edo, J. and Mahmood, A. and Phipps, M.E. (2010) Molecular analysis of HLA Class I and Class II genes in four indigenous Malaysian populations. Tissue Antigens, 75 (2). pp. 151-158.
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
spellingShingle Q Science (General)
Jinam, T.A.
Saitou, N.
Edo, J.
Mahmood, A.
Phipps, M.E.
Molecular analysis of HLA Class I and Class II genes in four indigenous Malaysian populations
description This is the first report of high-resolution human leukocyte antigen (HLA) typing in four indigenous groups in Malaysia. A total of 99 normal, healthy participants representing the Negrito (Jehai and Kensiu), Proto-Malay (Temuan) and a native group of Borneo (Bidayuh) were typed for HLA-A, -B, -DRB1 and -DQB1 genes using sequence-based typing. Eleven HLA-A, 26 HLA-B, 16 HLA-DRB1 and 14 HLA-DQB1 alleles were detected, including a new allele, HLA-B*3589 in the Jehai. Highly frequent alleles were A*2407, B*1513, B*1801, DRB1*0901, DRB1*1202, DRB1*1502, DQB1*0303 and DQB1*0502. Principal component analysis based on high-resolution HLA-A, -B and -DRB1 allele frequencies showed close affinities among all four groups, including the Negritos, with other Southeast Asian populations. These results showed the scope of HLA diversity in these indigenous minority groups and may prove beneficial for future disease association, anthropological and forensic studies.
format Article
author Jinam, T.A.
Saitou, N.
Edo, J.
Mahmood, A.
Phipps, M.E.
author_facet Jinam, T.A.
Saitou, N.
Edo, J.
Mahmood, A.
Phipps, M.E.
author_sort Jinam, T.A.
title Molecular analysis of HLA Class I and Class II genes in four indigenous Malaysian populations
title_short Molecular analysis of HLA Class I and Class II genes in four indigenous Malaysian populations
title_full Molecular analysis of HLA Class I and Class II genes in four indigenous Malaysian populations
title_fullStr Molecular analysis of HLA Class I and Class II genes in four indigenous Malaysian populations
title_full_unstemmed Molecular analysis of HLA Class I and Class II genes in four indigenous Malaysian populations
title_sort molecular analysis of hla class i and class ii genes in four indigenous malaysian populations
publisher Blackwell Publishing
publishDate 2010
url http://eprints.um.edu.my/15261/
_version_ 1643690015825330176
score 13.211869

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