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The utility of immature reticulocyte fraction as an indicator of erythropoietic response to altitude training in elite cyclists

P>Altitude training is sometimes employed by elite endurance athletes to improve their sea level performance. This improvement results from the increased red cell mass consequent upon the boost in erythropoietin (EPO) level that occurs as a response to the relatively hypoxic environment at high a...

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Main Authors: Nadarajan, V.S., Ooi, C.H., Sthaneshwar, P., Thompson, M.W.
Format: Article
Published: Wiley-Blackwell Publishing, Inc 2010
Subjects:
Q Science (General)
Online Access:http://eprints.um.edu.my/15238/
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spelling my.um.eprints.152382015-12-23T02:34:19Z http://eprints.um.edu.my/15238/ The utility of immature reticulocyte fraction as an indicator of erythropoietic response to altitude training in elite cyclists Nadarajan, V.S. Ooi, C.H. Sthaneshwar, P. Thompson, M.W. Q Science (General) P>Altitude training is sometimes employed by elite endurance athletes to improve their sea level performance. This improvement results from the increased red cell mass consequent upon the boost in erythropoietin (EPO) level that occurs as a response to the relatively hypoxic environment at high altitudes. We measured serum EPO levels together with various red cell and reticulocyte parameters including immature reticulocyte fraction (IRF) in eight national track-endurance cyclists, resident at sea-level, prior to and upon return from an altitude of approximately 1905 m. Reticulocytes and soluble transferrin receptor (sTfR) were significantly increased with reduction in ferritin levels immediately on return from high altitude indicating increased erythropoietic activity. IRF in particular showed a significant peak immediately on return but decline to sub-baseline levels by day 9, and recovery to baseline by day 16. Our results indicate that IRF is a sensitive marker of erythropoietic status in athletes undergoing altitude training and subsequent loss of EPO stimuli on return to sea level. Wiley-Blackwell Publishing, Inc 2010 Article PeerReviewed Nadarajan, V.S. and Ooi, C.H. and Sthaneshwar, P. and Thompson, M.W. (2010) The utility of immature reticulocyte fraction as an indicator of erythropoietic response to altitude training in elite cyclists. International Journal of Laboratory Hematology, 32 (1, 2). pp. 82-87.
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
spellingShingle Q Science (General)
Nadarajan, V.S.
Ooi, C.H.
Sthaneshwar, P.
Thompson, M.W.
The utility of immature reticulocyte fraction as an indicator of erythropoietic response to altitude training in elite cyclists
description P>Altitude training is sometimes employed by elite endurance athletes to improve their sea level performance. This improvement results from the increased red cell mass consequent upon the boost in erythropoietin (EPO) level that occurs as a response to the relatively hypoxic environment at high altitudes. We measured serum EPO levels together with various red cell and reticulocyte parameters including immature reticulocyte fraction (IRF) in eight national track-endurance cyclists, resident at sea-level, prior to and upon return from an altitude of approximately 1905 m. Reticulocytes and soluble transferrin receptor (sTfR) were significantly increased with reduction in ferritin levels immediately on return from high altitude indicating increased erythropoietic activity. IRF in particular showed a significant peak immediately on return but decline to sub-baseline levels by day 9, and recovery to baseline by day 16. Our results indicate that IRF is a sensitive marker of erythropoietic status in athletes undergoing altitude training and subsequent loss of EPO stimuli on return to sea level.
format Article
author Nadarajan, V.S.
Ooi, C.H.
Sthaneshwar, P.
Thompson, M.W.
author_facet Nadarajan, V.S.
Ooi, C.H.
Sthaneshwar, P.
Thompson, M.W.
author_sort Nadarajan, V.S.
title The utility of immature reticulocyte fraction as an indicator of erythropoietic response to altitude training in elite cyclists
title_short The utility of immature reticulocyte fraction as an indicator of erythropoietic response to altitude training in elite cyclists
title_full The utility of immature reticulocyte fraction as an indicator of erythropoietic response to altitude training in elite cyclists
title_fullStr The utility of immature reticulocyte fraction as an indicator of erythropoietic response to altitude training in elite cyclists
title_full_unstemmed The utility of immature reticulocyte fraction as an indicator of erythropoietic response to altitude training in elite cyclists
title_sort utility of immature reticulocyte fraction as an indicator of erythropoietic response to altitude training in elite cyclists
publisher Wiley-Blackwell Publishing, Inc
publishDate 2010
url http://eprints.um.edu.my/15238/
_version_ 1643690009994199040
score 13.211869

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