Staff View: Impulsive-compulsive behaviors are common in Asian Parkinson's disease patients: Assessment using the QUIP

Impulsive-compulsive behaviors are common in Asian Parkinson's disease patients: Assessment using the QUIP

Background: There are limited data on the prevalence of impulsive-compulsive behaviors and subsyndromal impulsive-compulsive behaviors in Asian patients with Parkinson's disease, who are treated with lower dosages of dopaminergic medications. Methods: The recently-validated Questionnaire for Im...

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Main Authors:	Lim, Shen-Yang, Tan, Z.K., Ngam, P.I., Lor, T.L., Mohamed, H., Schee, J.P., Tan, A.K., Goh, J.Y., Ooi, E., Soh, P.Chin-Hooi
Format:	Article
Published:	Elsevier 2010
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/14698/
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spelling	my.um.eprints.146982015-11-09T01:44:35Z http://eprints.um.edu.my/14698/ Impulsive-compulsive behaviors are common in Asian Parkinson's disease patients: Assessment using the QUIP Lim, Shen-Yang Tan, Z.K. Ngam, P.I. Lor, T.L. Mohamed, H. Schee, J.P. Tan, A.K. Goh, J.Y. Ooi, E. Soh, P.Chin-Hooi R Medicine Background: There are limited data on the prevalence of impulsive-compulsive behaviors and subsyndromal impulsive-compulsive behaviors in Asian patients with Parkinson's disease, who are treated with lower dosages of dopaminergic medications. Methods: The recently-validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease was administered to 200 consecutive patients attending a Malaysian university-based neurology clinic. Informant report was also systematically obtained. Results: A high rate of Questionnaire positivity was found (35.0% by combined patient and informant report; 24.6% by patient report alone; 27.4% by informant report alone), despite usage of relatively low dosages of dopaminergic medications (mean/median total L-dopa equivalent units of 528/450 mg/day; mean/median agonist-only L-dopa equivalent units of 74/37 mg/day). Eating, sexual and punding or hobbyism behaviors were relatively common, while gambling and compulsive medication use occurred less frequently. Agreement between patient- and informant-reporting of impulsive-compulsive behaviors was moderate-to-fair (Kappa values ranging from 0.203 to 0.494). Factors associated with Questionnaire positivity on univariate analysis were male gender, younger age at Parkinson's disease onset, longer disease duration, use of dopamine agonist or amantadine therapy, higher total L-dopa equivalent units and higher dopamine agonist-only L-dopa equivalent units. On multivariate analysis, male gender and longer disease duration independently predicted Questionnaire positivity. No association was found with cognitive or apathy scores. Conclusions: Our findings suggest that Asian patients with Parkinson's disease may be susceptible to dopaminergic medication-related side effects. The data here also contribute to the understanding of the psychometric properties of the Questionnaire for Impulsive-Compulsive Disorders. (C) 2011 Elsevier Ltd. All rights reserved. Elsevier 2010 Article PeerReviewed Lim, Shen-Yang and Tan, Z.K. and Ngam, P.I. and Lor, T.L. and Mohamed, H. and Schee, J.P. and Tan, A.K. and Goh, J.Y. and Ooi, E. and Soh, P.Chin-Hooi (2010) Impulsive-compulsive behaviors are common in Asian Parkinson's disease patients: Assessment using the QUIP. Parkinsonism & Related Disorders, 17 (10). pp. 761-764.
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine
spellingShingle	R Medicine Lim, Shen-Yang Tan, Z.K. Ngam, P.I. Lor, T.L. Mohamed, H. Schee, J.P. Tan, A.K. Goh, J.Y. Ooi, E. Soh, P.Chin-Hooi Impulsive-compulsive behaviors are common in Asian Parkinson's disease patients: Assessment using the QUIP
description	Background: There are limited data on the prevalence of impulsive-compulsive behaviors and subsyndromal impulsive-compulsive behaviors in Asian patients with Parkinson's disease, who are treated with lower dosages of dopaminergic medications. Methods: The recently-validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease was administered to 200 consecutive patients attending a Malaysian university-based neurology clinic. Informant report was also systematically obtained. Results: A high rate of Questionnaire positivity was found (35.0% by combined patient and informant report; 24.6% by patient report alone; 27.4% by informant report alone), despite usage of relatively low dosages of dopaminergic medications (mean/median total L-dopa equivalent units of 528/450 mg/day; mean/median agonist-only L-dopa equivalent units of 74/37 mg/day). Eating, sexual and punding or hobbyism behaviors were relatively common, while gambling and compulsive medication use occurred less frequently. Agreement between patient- and informant-reporting of impulsive-compulsive behaviors was moderate-to-fair (Kappa values ranging from 0.203 to 0.494). Factors associated with Questionnaire positivity on univariate analysis were male gender, younger age at Parkinson's disease onset, longer disease duration, use of dopamine agonist or amantadine therapy, higher total L-dopa equivalent units and higher dopamine agonist-only L-dopa equivalent units. On multivariate analysis, male gender and longer disease duration independently predicted Questionnaire positivity. No association was found with cognitive or apathy scores. Conclusions: Our findings suggest that Asian patients with Parkinson's disease may be susceptible to dopaminergic medication-related side effects. The data here also contribute to the understanding of the psychometric properties of the Questionnaire for Impulsive-Compulsive Disorders. (C) 2011 Elsevier Ltd. All rights reserved.
format	Article
author	Lim, Shen-Yang Tan, Z.K. Ngam, P.I. Lor, T.L. Mohamed, H. Schee, J.P. Tan, A.K. Goh, J.Y. Ooi, E. Soh, P.Chin-Hooi
author_facet	Lim, Shen-Yang Tan, Z.K. Ngam, P.I. Lor, T.L. Mohamed, H. Schee, J.P. Tan, A.K. Goh, J.Y. Ooi, E. Soh, P.Chin-Hooi
author_sort	Lim, Shen-Yang
title	Impulsive-compulsive behaviors are common in Asian Parkinson's disease patients: Assessment using the QUIP
title_short	Impulsive-compulsive behaviors are common in Asian Parkinson's disease patients: Assessment using the QUIP
title_full	Impulsive-compulsive behaviors are common in Asian Parkinson's disease patients: Assessment using the QUIP
title_fullStr	Impulsive-compulsive behaviors are common in Asian Parkinson's disease patients: Assessment using the QUIP
title_full_unstemmed	Impulsive-compulsive behaviors are common in Asian Parkinson's disease patients: Assessment using the QUIP
title_sort	impulsive-compulsive behaviors are common in asian parkinson's disease patients: assessment using the quip
publisher	Elsevier
publishDate	2010
url	http://eprints.um.edu.my/14698/
_version_	1643689879899471872
score	13.211869

Impulsive-compulsive behaviors are common in Asian Parkinson's disease patients: Assessment using the QUIP

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