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Fiducial registration error as a statistical process control metric in image-guidance radiotherapy with fiducial markers

Portal imaging of implanted fiducial markers has been in use for image-guided radiotherapy (IGRT) of prostate cancer, with ample attention to localization accuracy and organ motion. The geometric uncertainties in point-based rigid-body matching algorithms during localization of prostate fiducial mar...

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Main Authors: Ung, N.M., Wee, L.
Format: Article
Published: IOP Publishing 2011
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/14555/
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spelling my.um.eprints.145552020-01-03T04:19:07Z http://eprints.um.edu.my/14555/ Fiducial registration error as a statistical process control metric in image-guidance radiotherapy with fiducial markers Ung, N.M. Wee, L. R Medicine Portal imaging of implanted fiducial markers has been in use for image-guided radiotherapy (IGRT) of prostate cancer, with ample attention to localization accuracy and organ motion. The geometric uncertainties in point-based rigid-body matching algorithms during localization of prostate fiducial markers can be quantified in terms of a fiducial registration error (FRE). In this study, the aim is to demonstrate how statistical process control (SPC) can be used to intercept potential problems with rigid-body matching algorithms in a retrospective study of FRE for a pilot cohort of 34 patients with fiducial markers. A procedure for estimating control parameters of a SPC control chart (x-chart) from a small number of initial observations (N) of FRE was implemented. The sensitivity analysis of N on the number of `in-control' and `out-of-control' x-charts was also performed. Uncorrected rotational offsets of an individual patient were examined to elucidate possible correlations with the behaviours of an x-chart. Four specific types of qualitative x-chart behaviour have been observed. The number of out-of-control processes was insensitive to the choice of N, provided N >= 5. Residual errors of rigid-body registration were contributed from uncorrected rotational offsets in 5 out of 15 `out-of-control' x-charts. Out-ofcontrol x-charts were also shown to be correlated with potential changes in the IGRT processes, which may compromise the quality of the radiation treatment delivery. The SPC methodology, implemented in the form of individually customized x-charts, has been shown to be a useful tool for monitoring process reliability during fiducial-based IGRT for prostate cancer. IOP Publishing 2011 Article PeerReviewed Ung, N.M. and Wee, L. (2011) Fiducial registration error as a statistical process control metric in image-guidance radiotherapy with fiducial markers. Physics in Medicine & Biology, 56 (23). pp. 7473-7485. ISSN 0031-9155
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Ung, N.M.
Wee, L.
Fiducial registration error as a statistical process control metric in image-guidance radiotherapy with fiducial markers
description Portal imaging of implanted fiducial markers has been in use for image-guided radiotherapy (IGRT) of prostate cancer, with ample attention to localization accuracy and organ motion. The geometric uncertainties in point-based rigid-body matching algorithms during localization of prostate fiducial markers can be quantified in terms of a fiducial registration error (FRE). In this study, the aim is to demonstrate how statistical process control (SPC) can be used to intercept potential problems with rigid-body matching algorithms in a retrospective study of FRE for a pilot cohort of 34 patients with fiducial markers. A procedure for estimating control parameters of a SPC control chart (x-chart) from a small number of initial observations (N) of FRE was implemented. The sensitivity analysis of N on the number of `in-control' and `out-of-control' x-charts was also performed. Uncorrected rotational offsets of an individual patient were examined to elucidate possible correlations with the behaviours of an x-chart. Four specific types of qualitative x-chart behaviour have been observed. The number of out-of-control processes was insensitive to the choice of N, provided N >= 5. Residual errors of rigid-body registration were contributed from uncorrected rotational offsets in 5 out of 15 `out-of-control' x-charts. Out-ofcontrol x-charts were also shown to be correlated with potential changes in the IGRT processes, which may compromise the quality of the radiation treatment delivery. The SPC methodology, implemented in the form of individually customized x-charts, has been shown to be a useful tool for monitoring process reliability during fiducial-based IGRT for prostate cancer.
format Article
author Ung, N.M.
Wee, L.
author_facet Ung, N.M.
Wee, L.
author_sort Ung, N.M.
title Fiducial registration error as a statistical process control metric in image-guidance radiotherapy with fiducial markers
title_short Fiducial registration error as a statistical process control metric in image-guidance radiotherapy with fiducial markers
title_full Fiducial registration error as a statistical process control metric in image-guidance radiotherapy with fiducial markers
title_fullStr Fiducial registration error as a statistical process control metric in image-guidance radiotherapy with fiducial markers
title_full_unstemmed Fiducial registration error as a statistical process control metric in image-guidance radiotherapy with fiducial markers
title_sort fiducial registration error as a statistical process control metric in image-guidance radiotherapy with fiducial markers
publisher IOP Publishing
publishDate 2011
url http://eprints.um.edu.my/14555/
_version_ 1654960664403247104
score 13.211869

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