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A new mechanism of thermal sensitivity for rapid drug release and low systemic toxicity in hyperthermia and thermal ablation temperature ranges

Purpose: The aim of this paper was to introduce a new mechanism of thermal sensitivity in nanocarriers that results in a relatively low drug release at physiological temperature and rapid release of the encapsulated drug at hyperthermia and thermal ablation temperature range (4060 degrees C). Materi...

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Main Authors: Dabbagh, Ali, Abdullah, Basri Johan Jeet, Abu Kasim, Noor Hayaty, Abdullah, Hadijah, Abd Shukor, Mohd Hamdi
Format: Article
Language:English
Published: Taylor & Francis 2015
Subjects:
RK Dentistry
Online Access:http://eprints.um.edu.my/14011/1/A_new_mechanism_of_thermal_sensitivity_for_rapid_drug_release_and_low_systemic_toxicity_in_hyperthermia_and_thermal_ablation_temperature_ranges.pdf
http://eprints.um.edu.my/14011/
https://doi.org/10.3109/02656736.2015.1006268
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spelling my.um.eprints.140112021-10-01T07:37:54Z http://eprints.um.edu.my/14011/ A new mechanism of thermal sensitivity for rapid drug release and low systemic toxicity in hyperthermia and thermal ablation temperature ranges Dabbagh, Ali Abdullah, Basri Johan Jeet Abu Kasim, Noor Hayaty Abdullah, Hadijah Abd Shukor, Mohd Hamdi RK Dentistry Purpose: The aim of this paper was to introduce a new mechanism of thermal sensitivity in nanocarriers that results in a relatively low drug release at physiological temperature and rapid release of the encapsulated drug at hyperthermia and thermal ablation temperature range (4060 degrees C). Materials and methods: The nanocarriers were synthesised by coating mesoporous silica nanoparticles with a thin layer of polyacrylamide. The low gelation temperature of the protective shell provides preferred routes for drug diffusion when the nanocarriers are heated within the hyperthermia temperature range. In order to determine the gelation point of polyacrylamide shell, differential scanning calorimetry was used. Various chemical, morphological, thermal, as well as drug loading capacities of these nanocarriers were characterised and their drug release behaviour was examined using magnetic resonance - guided focused ultrasound (MRgFUS). Results: Drug release measurements at different temperatures using doxorubicin showed 11.5 +/- 2.4% leakage in aqueous solution at 37 degrees C after 30 min, while this value was significantly increased to 67.6 +/- 2.5% at 60 degrees C. A 39.2 +/- 2.2% release of doxorubicin was also obtained due to the sonication of drug-loaded nanoparticles for 5 x 20 s using MRgFUS. Conclusion: The nanocarriers developed do not exhibit a sharp transition temperature. However, a relatively high loading efficiency as well as rapid drug release at thermal ablation temperature range makes these nanostructures promising candidates for application as adjuvants to various thermal modalities such as radiofrequency and high intensity focused ultrasound. Taylor & Francis 2015-06 Article PeerReviewed application/pdf en http://eprints.um.edu.my/14011/1/A_new_mechanism_of_thermal_sensitivity_for_rapid_drug_release_and_low_systemic_toxicity_in_hyperthermia_and_thermal_ablation_temperature_ranges.pdf Dabbagh, Ali and Abdullah, Basri Johan Jeet and Abu Kasim, Noor Hayaty and Abdullah, Hadijah and Abd Shukor, Mohd Hamdi (2015) A new mechanism of thermal sensitivity for rapid drug release and low systemic toxicity in hyperthermia and thermal ablation temperature ranges. International Journal of Hyperthermia, 31 (4). pp. 375-385. ISSN 0265-6736 https://doi.org/10.3109/02656736.2015.1006268 10.3109/02656736.2015.1006268
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic RK Dentistry
spellingShingle RK Dentistry
Dabbagh, Ali
Abdullah, Basri Johan Jeet
Abu Kasim, Noor Hayaty
Abdullah, Hadijah
Abd Shukor, Mohd Hamdi
A new mechanism of thermal sensitivity for rapid drug release and low systemic toxicity in hyperthermia and thermal ablation temperature ranges
description Purpose: The aim of this paper was to introduce a new mechanism of thermal sensitivity in nanocarriers that results in a relatively low drug release at physiological temperature and rapid release of the encapsulated drug at hyperthermia and thermal ablation temperature range (4060 degrees C). Materials and methods: The nanocarriers were synthesised by coating mesoporous silica nanoparticles with a thin layer of polyacrylamide. The low gelation temperature of the protective shell provides preferred routes for drug diffusion when the nanocarriers are heated within the hyperthermia temperature range. In order to determine the gelation point of polyacrylamide shell, differential scanning calorimetry was used. Various chemical, morphological, thermal, as well as drug loading capacities of these nanocarriers were characterised and their drug release behaviour was examined using magnetic resonance - guided focused ultrasound (MRgFUS). Results: Drug release measurements at different temperatures using doxorubicin showed 11.5 +/- 2.4% leakage in aqueous solution at 37 degrees C after 30 min, while this value was significantly increased to 67.6 +/- 2.5% at 60 degrees C. A 39.2 +/- 2.2% release of doxorubicin was also obtained due to the sonication of drug-loaded nanoparticles for 5 x 20 s using MRgFUS. Conclusion: The nanocarriers developed do not exhibit a sharp transition temperature. However, a relatively high loading efficiency as well as rapid drug release at thermal ablation temperature range makes these nanostructures promising candidates for application as adjuvants to various thermal modalities such as radiofrequency and high intensity focused ultrasound.
format Article
author Dabbagh, Ali
Abdullah, Basri Johan Jeet
Abu Kasim, Noor Hayaty
Abdullah, Hadijah
Abd Shukor, Mohd Hamdi
author_facet Dabbagh, Ali
Abdullah, Basri Johan Jeet
Abu Kasim, Noor Hayaty
Abdullah, Hadijah
Abd Shukor, Mohd Hamdi
author_sort Dabbagh, Ali
title A new mechanism of thermal sensitivity for rapid drug release and low systemic toxicity in hyperthermia and thermal ablation temperature ranges
title_short A new mechanism of thermal sensitivity for rapid drug release and low systemic toxicity in hyperthermia and thermal ablation temperature ranges
title_full A new mechanism of thermal sensitivity for rapid drug release and low systemic toxicity in hyperthermia and thermal ablation temperature ranges
title_fullStr A new mechanism of thermal sensitivity for rapid drug release and low systemic toxicity in hyperthermia and thermal ablation temperature ranges
title_full_unstemmed A new mechanism of thermal sensitivity for rapid drug release and low systemic toxicity in hyperthermia and thermal ablation temperature ranges
title_sort new mechanism of thermal sensitivity for rapid drug release and low systemic toxicity in hyperthermia and thermal ablation temperature ranges
publisher Taylor & Francis
publishDate 2015
url http://eprints.um.edu.my/14011/1/A_new_mechanism_of_thermal_sensitivity_for_rapid_drug_release_and_low_systemic_toxicity_in_hyperthermia_and_thermal_ablation_temperature_ranges.pdf
http://eprints.um.edu.my/14011/
https://doi.org/10.3109/02656736.2015.1006268
_version_ 1713200123486404608
score 13.211869

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