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Characterization of nickel-doped biphasic calcium phosphate/graphene nanoplatelet composites for biomedical application

The effect of the addition of an ionic dopant to calcium phosphates for biomedical applications requires specific research due to the essential roles played in such processes. In the present study, the mechanical and biological properties of Ni-doped hydroxyapatite (HA) and Ni-doped HA mixed with gr...

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Main Authors: Baradaran, S., Moghaddam, E., Nasiri-Tabrizi, B., Basirun, Wan Jefrey, Mehrali, M., Sookhakian, M., Hamdi, M., Alias, Y.
Format: Article
Language:English
Published: Elsevier 2015
Subjects:
T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
Online Access:http://eprints.um.edu.my/13941/1/Characterization_of_nickel-doped_biphasic_calcium.pdf
http://eprints.um.edu.my/13941/
http://www.sciencedirect.com/science/article/pii/S0928493115000600
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spelling my.um.eprints.139412019-01-31T07:30:29Z http://eprints.um.edu.my/13941/ Characterization of nickel-doped biphasic calcium phosphate/graphene nanoplatelet composites for biomedical application Baradaran, S. Moghaddam, E. Nasiri-Tabrizi, B. Basirun, Wan Jefrey Mehrali, M. Sookhakian, M. Hamdi, M. Alias, Y. T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery The effect of the addition of an ionic dopant to calcium phosphates for biomedical applications requires specific research due to the essential roles played in such processes. In the present study, the mechanical and biological properties of Ni-doped hydroxyapatite (HA) and Ni-doped HA mixed with graphene nanoplatelets (GNPs) were evaluated. Ni (3 wt. and 6 wt.)-doped HA was synthesized using a continuous precipitation method and calcined at 900 degrees C for 1 h. The GNP (0.5-2 wt.)-reinforced 6 Ni-doped HA (Ni6) composite was prepared using rotary ball milling for 15 h. The sintering process was performed using hot isostatic pressing at processing conditions of 1150 degrees C and 160 MPa with a 1-h holding time. The results indicated that the phase compositions and structural features of the products were noticeably affected by the Ni and GNPs. The mechanical properties of Ni6 and 1.5Ni6 were increased by 55 and 75 in hardness, 59 and 163 in fracture toughness and 120 and 85 in elastic modulus compared with monolithic HA, respectively. The in-vitro biological behavior was investigated using h-FOB osteoblast cells in 1, 3 and 5 days of culture. Based on the osteoblast results, the cytotoxicity of the products was indeed affected by the Ni doping. In addition, the effect of GNPs on the growth and proliferation of osteoblast cells was investigated in Ni6 composites containing different ratios of GNPs, where 1.5 wt. was the optimum value. (C) 2015 Elsevier B.V. All rights reserved. Elsevier 2015-04 Article PeerReviewed application/pdf en http://eprints.um.edu.my/13941/1/Characterization_of_nickel-doped_biphasic_calcium.pdf Baradaran, S. and Moghaddam, E. and Nasiri-Tabrizi, B. and Basirun, Wan Jefrey and Mehrali, M. and Sookhakian, M. and Hamdi, M. and Alias, Y. (2015) Characterization of nickel-doped biphasic calcium phosphate/graphene nanoplatelet composites for biomedical application. Materials Science and Engineering: C, 49. pp. 656-668. ISSN 0928-4931 http://www.sciencedirect.com/science/article/pii/S0928493115000600 10.1016/j.msec.2015.01.050
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
spellingShingle T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
Baradaran, S.
Moghaddam, E.
Nasiri-Tabrizi, B.
Basirun, Wan Jefrey
Mehrali, M.
Sookhakian, M.
Hamdi, M.
Alias, Y.
Characterization of nickel-doped biphasic calcium phosphate/graphene nanoplatelet composites for biomedical application
description The effect of the addition of an ionic dopant to calcium phosphates for biomedical applications requires specific research due to the essential roles played in such processes. In the present study, the mechanical and biological properties of Ni-doped hydroxyapatite (HA) and Ni-doped HA mixed with graphene nanoplatelets (GNPs) were evaluated. Ni (3 wt. and 6 wt.)-doped HA was synthesized using a continuous precipitation method and calcined at 900 degrees C for 1 h. The GNP (0.5-2 wt.)-reinforced 6 Ni-doped HA (Ni6) composite was prepared using rotary ball milling for 15 h. The sintering process was performed using hot isostatic pressing at processing conditions of 1150 degrees C and 160 MPa with a 1-h holding time. The results indicated that the phase compositions and structural features of the products were noticeably affected by the Ni and GNPs. The mechanical properties of Ni6 and 1.5Ni6 were increased by 55 and 75 in hardness, 59 and 163 in fracture toughness and 120 and 85 in elastic modulus compared with monolithic HA, respectively. The in-vitro biological behavior was investigated using h-FOB osteoblast cells in 1, 3 and 5 days of culture. Based on the osteoblast results, the cytotoxicity of the products was indeed affected by the Ni doping. In addition, the effect of GNPs on the growth and proliferation of osteoblast cells was investigated in Ni6 composites containing different ratios of GNPs, where 1.5 wt. was the optimum value. (C) 2015 Elsevier B.V. All rights reserved.
format Article
author Baradaran, S.
Moghaddam, E.
Nasiri-Tabrizi, B.
Basirun, Wan Jefrey
Mehrali, M.
Sookhakian, M.
Hamdi, M.
Alias, Y.
author_facet Baradaran, S.
Moghaddam, E.
Nasiri-Tabrizi, B.
Basirun, Wan Jefrey
Mehrali, M.
Sookhakian, M.
Hamdi, M.
Alias, Y.
author_sort Baradaran, S.
title Characterization of nickel-doped biphasic calcium phosphate/graphene nanoplatelet composites for biomedical application
title_short Characterization of nickel-doped biphasic calcium phosphate/graphene nanoplatelet composites for biomedical application
title_full Characterization of nickel-doped biphasic calcium phosphate/graphene nanoplatelet composites for biomedical application
title_fullStr Characterization of nickel-doped biphasic calcium phosphate/graphene nanoplatelet composites for biomedical application
title_full_unstemmed Characterization of nickel-doped biphasic calcium phosphate/graphene nanoplatelet composites for biomedical application
title_sort characterization of nickel-doped biphasic calcium phosphate/graphene nanoplatelet composites for biomedical application
publisher Elsevier
publishDate 2015
url http://eprints.um.edu.my/13941/1/Characterization_of_nickel-doped_biphasic_calcium.pdf
http://eprints.um.edu.my/13941/
http://www.sciencedirect.com/science/article/pii/S0928493115000600
_version_ 1643689690069467136
score 13.211869

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