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Guided routing on spinning microfluidic platforms

Flow directionality, valving and liquid routing in centrifugal microfluidics (Lab-on-CD) are typically controlled by applying centrifugal and Coriolis forces and have been the subject of active research interest in recent years. Determining and switching the flow direction at a T-junction is a commo...

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Main Authors:	Kazemzadeh, A., Ganesan, P., Ibrahim, F., Kulinsky, L., Madou, M.J.
Format:	Article
Language:	English
Published:	Royal Society of Chemistry 2015
Subjects:	T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery
Online Access:	http://eprints.um.edu.my/13765/1/Guided_routing_on_spinning_microfluidic_platforms.pdf http://eprints.um.edu.my/13765/ http://pubs.rsc.org/en/content/articlehtml/2014/ra/c4ra14397c
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spelling	my.um.eprints.137652017-11-01T06:03:40Z http://eprints.um.edu.my/13765/ Guided routing on spinning microfluidic platforms Kazemzadeh, A. Ganesan, P. Ibrahim, F. Kulinsky, L. Madou, M.J. T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery Flow directionality, valving and liquid routing in centrifugal microfluidics (Lab-on-CD) are typically controlled by applying centrifugal and Coriolis forces and have been the subject of active research interest in recent years. Determining and switching the flow direction at a T-junction is a common fluidic operation important for implementing several chemical and clinical assays for Lab-on-CDs. The present work describes a novel approach to route samples and control flow direction on a spinning disc that employs a guiding microstructure that relies on a two-stage valve comprised of an auxiliary inlet, which is a recess embedded at a T-junction, and a bent auxiliary outlet. The distinctive feature that makes this approach different from other types of passive capillary valves is the strong control of liquid movement, which is achieved by employing two adjustable sequential burst valves called a primary valve and a secondary burst valve. The guiding method can be used to route samples and reagents at given flow rates to a selection of receiving reservoirs, which are determined by the spinning frequency of the disc. The technique also allows for the switching of the flow direction instantaneously from the direction along the disc rotation to the opposite direction by increasing the rotational speed of the disc rather than relying on the Coriolis force, which would require reversing the spin direction. The flow routing by the proposed technique has been studied theoretically, and the flow behavior has been numerically investigated. These studies have been experimentally validated for a wide range of capillary sizes and for various liquids including di-water, mixtures of water and ethanol and bovine serum albumin (BSA). Royal Society of Chemistry 2015 Article PeerReviewed application/pdf en http://eprints.um.edu.my/13765/1/Guided_routing_on_spinning_microfluidic_platforms.pdf Kazemzadeh, A. and Ganesan, P. and Ibrahim, F. and Kulinsky, L. and Madou, M.J. (2015) Guided routing on spinning microfluidic platforms. RSC Advances, 5 (12). pp. 8669-8679. ISSN 2046-2069 http://pubs.rsc.org/en/content/articlehtml/2014/ra/c4ra14397c Doi 10.1039/C4a14397c
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
language	English
topic	T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery
spellingShingle	T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery Kazemzadeh, A. Ganesan, P. Ibrahim, F. Kulinsky, L. Madou, M.J. Guided routing on spinning microfluidic platforms
description	Flow directionality, valving and liquid routing in centrifugal microfluidics (Lab-on-CD) are typically controlled by applying centrifugal and Coriolis forces and have been the subject of active research interest in recent years. Determining and switching the flow direction at a T-junction is a common fluidic operation important for implementing several chemical and clinical assays for Lab-on-CDs. The present work describes a novel approach to route samples and control flow direction on a spinning disc that employs a guiding microstructure that relies on a two-stage valve comprised of an auxiliary inlet, which is a recess embedded at a T-junction, and a bent auxiliary outlet. The distinctive feature that makes this approach different from other types of passive capillary valves is the strong control of liquid movement, which is achieved by employing two adjustable sequential burst valves called a primary valve and a secondary burst valve. The guiding method can be used to route samples and reagents at given flow rates to a selection of receiving reservoirs, which are determined by the spinning frequency of the disc. The technique also allows for the switching of the flow direction instantaneously from the direction along the disc rotation to the opposite direction by increasing the rotational speed of the disc rather than relying on the Coriolis force, which would require reversing the spin direction. The flow routing by the proposed technique has been studied theoretically, and the flow behavior has been numerically investigated. These studies have been experimentally validated for a wide range of capillary sizes and for various liquids including di-water, mixtures of water and ethanol and bovine serum albumin (BSA).
format	Article
author	Kazemzadeh, A. Ganesan, P. Ibrahim, F. Kulinsky, L. Madou, M.J.
author_facet	Kazemzadeh, A. Ganesan, P. Ibrahim, F. Kulinsky, L. Madou, M.J.
author_sort	Kazemzadeh, A.
title	Guided routing on spinning microfluidic platforms
title_short	Guided routing on spinning microfluidic platforms
title_full	Guided routing on spinning microfluidic platforms
title_fullStr	Guided routing on spinning microfluidic platforms
title_full_unstemmed	Guided routing on spinning microfluidic platforms
title_sort	guided routing on spinning microfluidic platforms
publisher	Royal Society of Chemistry
publishDate	2015
url	http://eprints.um.edu.my/13765/1/Guided_routing_on_spinning_microfluidic_platforms.pdf http://eprints.um.edu.my/13765/ http://pubs.rsc.org/en/content/articlehtml/2014/ra/c4ra14397c
_version_	1643689643508498432
score	13.211869

Guided routing on spinning microfluidic platforms

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