Staff View: Angiogenic factors in the pathogenesis and pathophysiology of preeclampsia: A Mini review

Angiogenic factors in the pathogenesis and pathophysiology of preeclampsia: A Mini review

Preeclampsia (PE) the de novo occurrence of hypertension and proteinuria after the 20(th) week of gestation is a major cause of maternal and fetal morbidity worldwide. While the etiology of PE is still unclear, clinical phenotypes have been associated with high circulating levels of anti-angiogenic...

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Main Authors:	Yelumalai, S., Subramanian, K., Omar, S.Z., Qvist, R., Muniandy, S.
Format:	Article
Published:	Scientific Publishers India 2010
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/12740/
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spelling	my.um.eprints.127402015-02-12T03:23:50Z http://eprints.um.edu.my/12740/ Angiogenic factors in the pathogenesis and pathophysiology of preeclampsia: A Mini review Yelumalai, S. Subramanian, K. Omar, S.Z. Qvist, R. Muniandy, S. R Medicine Preeclampsia (PE) the de novo occurrence of hypertension and proteinuria after the 20(th) week of gestation is a major cause of maternal and fetal morbidity worldwide. While the etiology of PE is still unclear, clinical phenotypes have been associated with high circulating levels of anti-angiogenic proteins such as soluble Fms-like tyrosine kinase 1 (sFlt1) and soluble endoglin (sEng). Furthermore PE is associated with low serum free placental growth factor (PIGF) and free vascular endothelial growth factor (VEGF). Since alterations in levels of these factors precede the onset of clinical disease, have these factors may be useful to screen or identify patients at risk for PE. Women with a history of PE have an increased risk of hypertension, and cardiovascular and renal disease Therefore, this raises the possibility of measuring circulating angiogenic proteins in the blood and the urine as a diagnostic and screening tool for PE. The availability of a test to predict PE would be a powerful tool in preventing PE-induced mortality, especially in developing nations, where high-risk specialists are limited. This review will summarize our current understanding of the role of circulating angiogenic proteins in the pathogenesis and clinical diagnosis/prediction of PE. Scientific Publishers India 2010 Article PeerReviewed Yelumalai, S. and Subramanian, K. and Omar, S.Z. and Qvist, R. and Muniandy, S. (2010) Angiogenic factors in the pathogenesis and pathophysiology of preeclampsia: A Mini review. Biomedical Research-India, 21 (3). pp. 246-251.
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine
spellingShingle	R Medicine Yelumalai, S. Subramanian, K. Omar, S.Z. Qvist, R. Muniandy, S. Angiogenic factors in the pathogenesis and pathophysiology of preeclampsia: A Mini review
description	Preeclampsia (PE) the de novo occurrence of hypertension and proteinuria after the 20(th) week of gestation is a major cause of maternal and fetal morbidity worldwide. While the etiology of PE is still unclear, clinical phenotypes have been associated with high circulating levels of anti-angiogenic proteins such as soluble Fms-like tyrosine kinase 1 (sFlt1) and soluble endoglin (sEng). Furthermore PE is associated with low serum free placental growth factor (PIGF) and free vascular endothelial growth factor (VEGF). Since alterations in levels of these factors precede the onset of clinical disease, have these factors may be useful to screen or identify patients at risk for PE. Women with a history of PE have an increased risk of hypertension, and cardiovascular and renal disease Therefore, this raises the possibility of measuring circulating angiogenic proteins in the blood and the urine as a diagnostic and screening tool for PE. The availability of a test to predict PE would be a powerful tool in preventing PE-induced mortality, especially in developing nations, where high-risk specialists are limited. This review will summarize our current understanding of the role of circulating angiogenic proteins in the pathogenesis and clinical diagnosis/prediction of PE.
format	Article
author	Yelumalai, S. Subramanian, K. Omar, S.Z. Qvist, R. Muniandy, S.
author_facet	Yelumalai, S. Subramanian, K. Omar, S.Z. Qvist, R. Muniandy, S.
author_sort	Yelumalai, S.
title	Angiogenic factors in the pathogenesis and pathophysiology of preeclampsia: A Mini review
title_short	Angiogenic factors in the pathogenesis and pathophysiology of preeclampsia: A Mini review
title_full	Angiogenic factors in the pathogenesis and pathophysiology of preeclampsia: A Mini review
title_fullStr	Angiogenic factors in the pathogenesis and pathophysiology of preeclampsia: A Mini review
title_full_unstemmed	Angiogenic factors in the pathogenesis and pathophysiology of preeclampsia: A Mini review
title_sort	angiogenic factors in the pathogenesis and pathophysiology of preeclampsia: a mini review
publisher	Scientific Publishers India
publishDate	2010
url	http://eprints.um.edu.my/12740/
_version_	1643689365158756352
score	13.211869

Angiogenic factors in the pathogenesis and pathophysiology of preeclampsia: A Mini review

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