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Efficacy of 1-week proton pump inhibitor triple therapy as first-line Helicobacter pylori eradication regime in Asian patients: Is it still effective 10 years on?

OBJECTIVE: To re-examine the efficacy and tolerability of 1-week proton pump inhibitor triple therapy as a first-line Helicobacter pylori (H. pylori) eradication therapy. METHODS: Consecutive participants with a positive rapid urease test during an outpatient upper endoscopy were included. All parti...

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Main Authors: Qua, Choon-Seng, Manikam, J., Goh, Khean Lee
Format: Article
Published: Wiley-Blackwell 2010
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R Medicine
Online Access:http://eprints.um.edu.my/12649/
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spelling my.um.eprints.126492019-02-07T09:24:42Z http://eprints.um.edu.my/12649/ Efficacy of 1-week proton pump inhibitor triple therapy as first-line Helicobacter pylori eradication regime in Asian patients: Is it still effective 10 years on? Qua, Choon-Seng Manikam, J. Goh, Khean Lee R Medicine OBJECTIVE: To re-examine the efficacy and tolerability of 1-week proton pump inhibitor triple therapy as a first-line Helicobacter pylori (H. pylori) eradication therapy. METHODS: Consecutive participants with a positive rapid urease test during an outpatient upper endoscopy were included. All participants were given pantoprazole 40 mg b.i.d., amoxycillin 1 g b.i.d. and clarithromycin 500 mg b.i.d. for 1 week. They were asked to return after 1 week to report any side effects related to the medications and to check for compliance. Successful eradication was defined by negative 13C-urea breath test at least 4 weeks after the completion of therapy. RESULTS: A total of 191 patients were recruited into the study, of whom 81 were male (42.4%) and 110 female (57.6%), with a mean age of 55.6 (range 21-88) years. Overall 26 patients (13.6%) defaulted follow up and five patients were not compliant (taking less than 85%) with the medications. Per-protocol and intention-to-treat eradication rates were 84.4% (95% CI: 78.6-89.9%) and 71.2% (95% CI: 64.5-77.6%), respectively. Overall 68 participants (42.5%) reported no side effects, followed by 58 (36.3%) with a taste disturbance, 16 (10.0%) with epigastric pain, 15 (9.4%) with diarrhea, 13 (8.1%) with nausea or vomiting, 12 (7.5%) with loss of appetite, nine (5.6%) with dizziness and two (1.3%) with an allergic skin rash, none of which was severe. CONCLUSION: The current regime using pantoprazole, amoxycillin and clarithromycin is highly tolerable and effective and should continue to be recommended as a first-line therapy for H. pylori eradication in our setting. Wiley-Blackwell 2010 Article PeerReviewed Qua, Choon-Seng and Manikam, J. and Goh, Khean Lee (2010) Efficacy of 1-week proton pump inhibitor triple therapy as first-line Helicobacter pylori eradication regime in Asian patients: Is it still effective 10 years on? Chinese Journal of Digestive Diseases, 11 (4). pp. 244-248. ISSN 1443-9611
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Qua, Choon-Seng
Manikam, J.
Goh, Khean Lee
Efficacy of 1-week proton pump inhibitor triple therapy as first-line Helicobacter pylori eradication regime in Asian patients: Is it still effective 10 years on?
description OBJECTIVE: To re-examine the efficacy and tolerability of 1-week proton pump inhibitor triple therapy as a first-line Helicobacter pylori (H. pylori) eradication therapy. METHODS: Consecutive participants with a positive rapid urease test during an outpatient upper endoscopy were included. All participants were given pantoprazole 40 mg b.i.d., amoxycillin 1 g b.i.d. and clarithromycin 500 mg b.i.d. for 1 week. They were asked to return after 1 week to report any side effects related to the medications and to check for compliance. Successful eradication was defined by negative 13C-urea breath test at least 4 weeks after the completion of therapy. RESULTS: A total of 191 patients were recruited into the study, of whom 81 were male (42.4%) and 110 female (57.6%), with a mean age of 55.6 (range 21-88) years. Overall 26 patients (13.6%) defaulted follow up and five patients were not compliant (taking less than 85%) with the medications. Per-protocol and intention-to-treat eradication rates were 84.4% (95% CI: 78.6-89.9%) and 71.2% (95% CI: 64.5-77.6%), respectively. Overall 68 participants (42.5%) reported no side effects, followed by 58 (36.3%) with a taste disturbance, 16 (10.0%) with epigastric pain, 15 (9.4%) with diarrhea, 13 (8.1%) with nausea or vomiting, 12 (7.5%) with loss of appetite, nine (5.6%) with dizziness and two (1.3%) with an allergic skin rash, none of which was severe. CONCLUSION: The current regime using pantoprazole, amoxycillin and clarithromycin is highly tolerable and effective and should continue to be recommended as a first-line therapy for H. pylori eradication in our setting.
format Article
author Qua, Choon-Seng
Manikam, J.
Goh, Khean Lee
author_facet Qua, Choon-Seng
Manikam, J.
Goh, Khean Lee
author_sort Qua, Choon-Seng
title Efficacy of 1-week proton pump inhibitor triple therapy as first-line Helicobacter pylori eradication regime in Asian patients: Is it still effective 10 years on?
title_short Efficacy of 1-week proton pump inhibitor triple therapy as first-line Helicobacter pylori eradication regime in Asian patients: Is it still effective 10 years on?
title_full Efficacy of 1-week proton pump inhibitor triple therapy as first-line Helicobacter pylori eradication regime in Asian patients: Is it still effective 10 years on?
title_fullStr Efficacy of 1-week proton pump inhibitor triple therapy as first-line Helicobacter pylori eradication regime in Asian patients: Is it still effective 10 years on?
title_full_unstemmed Efficacy of 1-week proton pump inhibitor triple therapy as first-line Helicobacter pylori eradication regime in Asian patients: Is it still effective 10 years on?
title_sort efficacy of 1-week proton pump inhibitor triple therapy as first-line helicobacter pylori eradication regime in asian patients: is it still effective 10 years on?
publisher Wiley-Blackwell
publishDate 2010
url http://eprints.um.edu.my/12649/
_version_ 1643689345422458880
score 13.211869

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