Cellular inhibitory behavior underlying the formation of retinal direction selectivity in the starburst network
Optical imaging of dendritic calcium signals provided evidence of starburst amacrine cells exhibiting calcium bias to somatofugal motion. In contrast, it has been impractical to use a dual-patch clamp technique to record membrane potentials from both proximal dendrites and distal varicosities of sta...
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2010
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my.um.eprints.124672015-01-29T02:56:56Z http://eprints.um.edu.my/12467/ Cellular inhibitory behavior underlying the formation of retinal direction selectivity in the starburst network Poznanski, R.R. R Medicine Optical imaging of dendritic calcium signals provided evidence of starburst amacrine cells exhibiting calcium bias to somatofugal motion. In contrast, it has been impractical to use a dual-patch clamp technique to record membrane potentials from both proximal dendrites and distal varicosities of starburst amacrine cells in order to unequivocally prove that they are directionally sensitive to voltage, as was first suggested almost two decades ago. This paper aims to extend the passive cable model to an active cable model of a starburst amacrine cell that is intrinsically dependent on the electrical properties of starburst amacrine cells, whose various macroscopic currents are described quantitatively. The coupling between voltage and calcium just below the membrane results in a voltage-calcium system of coupled nonlinear Volterra integral equations whose solutions must be integrated into a prescribed model for example, for a synaptic couplet of starburst amacrine cells. Networks of starburst amacrine cells play a fundamental role in the retinal circuitry underlying directional selectivity. It is suggested that the dendritic plexus of starburst amacrine cells provides the substrate for the property of directional selectivity, while directional selectivity is a property of the exclusive layerings and confinement of their interconnections within the sublaminae of the inner plexiform layer involving cone bipolar cells and directionally selective ganglion cells. Imperial College Press 2010 Article PeerReviewed Poznanski, R.R. (2010) Cellular inhibitory behavior underlying the formation of retinal direction selectivity in the starburst network. Journal of Integrative Neuroscience, 9 (3). pp. 299-335. |
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R Medicine Poznanski, R.R. Cellular inhibitory behavior underlying the formation of retinal direction selectivity in the starburst network |
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Optical imaging of dendritic calcium signals provided evidence of starburst amacrine cells exhibiting calcium bias to somatofugal motion. In contrast, it has been impractical to use a dual-patch clamp technique to record membrane potentials from both proximal dendrites and distal varicosities of starburst amacrine cells in order to unequivocally prove that they are directionally sensitive to voltage, as was first suggested almost two decades ago. This paper aims to extend the passive cable model to an active cable model of a starburst amacrine cell that is intrinsically dependent on the electrical properties of starburst amacrine cells, whose various macroscopic currents are described quantitatively. The coupling between voltage and calcium just below the membrane results in a voltage-calcium system of coupled nonlinear Volterra integral equations whose solutions must be integrated into a prescribed model for example, for a synaptic couplet of starburst amacrine cells. Networks of starburst amacrine cells play a fundamental role in the retinal circuitry underlying directional selectivity. It is suggested that the dendritic plexus of starburst amacrine cells provides the substrate for the property of directional selectivity, while directional selectivity is a property of the exclusive layerings and confinement of their interconnections within the sublaminae of the inner plexiform layer involving cone bipolar cells and directionally selective ganglion cells. |
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Article |
| author |
Poznanski, R.R. |
| author_facet |
Poznanski, R.R. |
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Poznanski, R.R. |
| title |
Cellular inhibitory behavior underlying the formation of retinal direction selectivity in the starburst network |
| title_short |
Cellular inhibitory behavior underlying the formation of retinal direction selectivity in the starburst network |
| title_full |
Cellular inhibitory behavior underlying the formation of retinal direction selectivity in the starburst network |
| title_fullStr |
Cellular inhibitory behavior underlying the formation of retinal direction selectivity in the starburst network |
| title_full_unstemmed |
Cellular inhibitory behavior underlying the formation of retinal direction selectivity in the starburst network |
| title_sort |
cellular inhibitory behavior underlying the formation of retinal direction selectivity in the starburst network |
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Imperial College Press |
| publishDate |
2010 |
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http://eprints.um.edu.my/12467/ |
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1643689304299405312 |
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13.211869 |