Epstein–Barr virus, the germinal centre and the development of Hodgkin’s lymphoma
The relationship between Epstein-Barr virus (EBV) and the germinal centre (GC) of the asymptomatic host remains an enigma. The occasional appearance of EBV-positive germinal centres in some patients, particularly those with a history of immunosuppression, suggests that EBV numbers in the GC are subj...
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Society for General Microbiology
2014
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| Online Access: | http://eprints.um.edu.my/11367/1/Epstein%E2%80%93Barr_virus%2C_the_germinal_centre_and_the_development_of_Hodgkin%E2%80%99s_lymphoma.pdf http://eprints.um.edu.my/11367/ http://www.ncbi.nlm.nih.gov/pubmed/24893782 |
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my.um.eprints.113672014-11-20T02:04:02Z http://eprints.um.edu.my/11367/ Epstein–Barr virus, the germinal centre and the development of Hodgkin’s lymphoma Mohamed, G. Vrzalikova, K. Cader, F.Z. Vockerodt, M. Nagy, E. Flodr, P. Yap, L.F. Diepstra, A. Kluin, P.M. Rosati, S. Murray, P. RK Dentistry The relationship between Epstein-Barr virus (EBV) and the germinal centre (GC) of the asymptomatic host remains an enigma. The occasional appearance of EBV-positive germinal centres in some patients, particularly those with a history of immunosuppression, suggests that EBV numbers in the GC are subject to immune control. The relationship, if any, between lymphoid hyperplasia with EBV-positive germinal centres and subsequent or concurrent lymphomagenesis remains to be clarified. As far as the development of EBV-associated Hodgkin's lymphoma is concerned, the suppression of virus replication, mediated by LMP1 on the one hand, and the loss of B-cell receptor signalling on the other, appears to be an important pathogenic mechanism. A further important emerging concept is that alterations in the microenvironment of the EBV-infected B-cell may be important for lymphomagenesis. Society for General Microbiology 2014 Article PeerReviewed application/pdf en http://eprints.um.edu.my/11367/1/Epstein%E2%80%93Barr_virus%2C_the_germinal_centre_and_the_development_of_Hodgkin%E2%80%99s_lymphoma.pdf Mohamed, G. and Vrzalikova, K. and Cader, F.Z. and Vockerodt, M. and Nagy, E. and Flodr, P. and Yap, L.F. and Diepstra, A. and Kluin, P.M. and Rosati, S. and Murray, P. (2014) Epstein–Barr virus, the germinal centre and the development of Hodgkin’s lymphoma. Journal of General Virology. ISSN 0022-1317 http://www.ncbi.nlm.nih.gov/pubmed/24893782 |
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RK Dentistry Mohamed, G. Vrzalikova, K. Cader, F.Z. Vockerodt, M. Nagy, E. Flodr, P. Yap, L.F. Diepstra, A. Kluin, P.M. Rosati, S. Murray, P. Epstein–Barr virus, the germinal centre and the development of Hodgkin’s lymphoma |
| description |
The relationship between Epstein-Barr virus (EBV) and the germinal centre (GC) of the asymptomatic host remains an enigma. The occasional appearance of EBV-positive germinal centres in some patients, particularly those with a history of immunosuppression, suggests that EBV numbers in the GC are subject to immune control. The relationship, if any, between lymphoid hyperplasia with EBV-positive germinal centres and subsequent or concurrent lymphomagenesis remains to be clarified. As far as the development of EBV-associated Hodgkin's lymphoma is concerned, the suppression of virus replication, mediated by LMP1 on the one hand, and the loss of B-cell receptor signalling on the other, appears to be an important pathogenic mechanism. A further important emerging concept is that alterations in the microenvironment of the EBV-infected B-cell may be important for lymphomagenesis.
|
| format |
Article |
| author |
Mohamed, G. Vrzalikova, K. Cader, F.Z. Vockerodt, M. Nagy, E. Flodr, P. Yap, L.F. Diepstra, A. Kluin, P.M. Rosati, S. Murray, P. |
| author_facet |
Mohamed, G. Vrzalikova, K. Cader, F.Z. Vockerodt, M. Nagy, E. Flodr, P. Yap, L.F. Diepstra, A. Kluin, P.M. Rosati, S. Murray, P. |
| author_sort |
Mohamed, G. |
| title |
Epstein–Barr virus, the germinal centre and the development of Hodgkin’s lymphoma
|
| title_short |
Epstein–Barr virus, the germinal centre and the development of Hodgkin’s lymphoma
|
| title_full |
Epstein–Barr virus, the germinal centre and the development of Hodgkin’s lymphoma
|
| title_fullStr |
Epstein–Barr virus, the germinal centre and the development of Hodgkin’s lymphoma
|
| title_full_unstemmed |
Epstein–Barr virus, the germinal centre and the development of Hodgkin’s lymphoma
|
| title_sort |
epstein–barr virus, the germinal centre and the development of hodgkin’s lymphoma |
| publisher |
Society for General Microbiology |
| publishDate |
2014 |
| url |
http://eprints.um.edu.my/11367/1/Epstein%E2%80%93Barr_virus%2C_the_germinal_centre_and_the_development_of_Hodgkin%E2%80%99s_lymphoma.pdf http://eprints.um.edu.my/11367/ http://www.ncbi.nlm.nih.gov/pubmed/24893782 |
| _version_ |
1643689039107194880 |
| score |
13.211869 |