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Efficacy and tolerability of lercanidipine in mild to moderate hypertension among Asians of different ethnic groups

Introduction: Calcium channel blockers are well established modalities for the treatment of hypertension. However, in spite of the availability of many efficacious agents, hypertension control continues to be poor. One reason is poor tolerability due to adverse events. Racial differences also exist....

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Main Authors: Chia, Yook Chin, Yeoh, E.S.H., Ng, C.J., Khoo, E.M., Chua, C.T.
Format: Article
Language:English
Published: Stamford Publishing Pte Ltd / Singapore Medical Association 2009
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/1115/1/Efficacy_and_tolerability_of_lercanidipine_in_mild_to_moderate_hyperetnsion_Chia_YC_SMJ_2009.pdf
http://eprints.um.edu.my/1115/
http://smj.sma.org.sg/5005/5005a8.pdf
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spelling my.um.eprints.11152020-07-13T07:17:08Z http://eprints.um.edu.my/1115/ Efficacy and tolerability of lercanidipine in mild to moderate hypertension among Asians of different ethnic groups Chia, Yook Chin Yeoh, E.S.H. Ng, C.J. Khoo, E.M. Chua, C.T. R Medicine Introduction: Calcium channel blockers are well established modalities for the treatment of hypertension. However, in spite of the availability of many efficacious agents, hypertension control continues to be poor. One reason is poor tolerability due to adverse events. Racial differences also exist. Lercanidipine, a third-generation calcium channel blocker, is associated with better tolerability. However, it has not been studied in the Asian population. This study examines its efficacy and tolerability in Asian subjects of different ethnicities. Methods: This was an eight-week open label study of adults with mild to moderate hypertension. Blood pressure (BP), pulse rate, self-administered symptom check and laboratory evaluations were done at baseline. Patients were prescribed 10 mg lercanidipine, with up-titration to 20 mg if BP was not controlled at Week 4. Baseline evaluations were repeated at Week 8. Adverse events were also enumerated. Results: 27 patients (mean age 53.4 +/- 12.1 years) completed the study. The baseline systolic BP (SBP), diastolic BP (DBP) and heart rate was 159 +/- 12.2, 96.6 +/- 7.7 mmHg and 71 +/- 13/min, respectively. Three racial groups were represented. SBP and DBP decreased significantly after four weeks of therapy. A further reduction to 139 +/- 14.3 and 88 +/- 9.8 (p-value is less than 0.0001) was seen in Week 8. The absolute SBP and DBP reduction was 20.5 mmHg (95 percent confidence interval [CI] 16.5-24.5, p-value is less than 0.0001) and 9.3 mmHg (95 percent CI 6.2-12.5, p-value is less than 0.0001), respectively. All adverse symptoms, except for palpitations, were reduced at the end of the study. Conclusion: Lercanidipine is efficacious and well tolerated in Asians of different ethnicities. Its BP lowering effects and tolerability in Asians appear to be similar to other studies on Caucasians and other calcium channel blockers. Stamford Publishing Pte Ltd / Singapore Medical Association 2009-05 Article PeerReviewed application/pdf en http://eprints.um.edu.my/1115/1/Efficacy_and_tolerability_of_lercanidipine_in_mild_to_moderate_hyperetnsion_Chia_YC_SMJ_2009.pdf Chia, Yook Chin and Yeoh, E.S.H. and Ng, C.J. and Khoo, E.M. and Chua, C.T. (2009) Efficacy and tolerability of lercanidipine in mild to moderate hypertension among Asians of different ethnic groups. Singapore Medical Journal, 50 (5). pp. 500-505. ISSN 0037-5675 http://smj.sma.org.sg/5005/5005a8.pdf 19495520
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine
spellingShingle R Medicine
Chia, Yook Chin
Yeoh, E.S.H.
Ng, C.J.
Khoo, E.M.
Chua, C.T.
Efficacy and tolerability of lercanidipine in mild to moderate hypertension among Asians of different ethnic groups
description Introduction: Calcium channel blockers are well established modalities for the treatment of hypertension. However, in spite of the availability of many efficacious agents, hypertension control continues to be poor. One reason is poor tolerability due to adverse events. Racial differences also exist. Lercanidipine, a third-generation calcium channel blocker, is associated with better tolerability. However, it has not been studied in the Asian population. This study examines its efficacy and tolerability in Asian subjects of different ethnicities. Methods: This was an eight-week open label study of adults with mild to moderate hypertension. Blood pressure (BP), pulse rate, self-administered symptom check and laboratory evaluations were done at baseline. Patients were prescribed 10 mg lercanidipine, with up-titration to 20 mg if BP was not controlled at Week 4. Baseline evaluations were repeated at Week 8. Adverse events were also enumerated. Results: 27 patients (mean age 53.4 +/- 12.1 years) completed the study. The baseline systolic BP (SBP), diastolic BP (DBP) and heart rate was 159 +/- 12.2, 96.6 +/- 7.7 mmHg and 71 +/- 13/min, respectively. Three racial groups were represented. SBP and DBP decreased significantly after four weeks of therapy. A further reduction to 139 +/- 14.3 and 88 +/- 9.8 (p-value is less than 0.0001) was seen in Week 8. The absolute SBP and DBP reduction was 20.5 mmHg (95 percent confidence interval [CI] 16.5-24.5, p-value is less than 0.0001) and 9.3 mmHg (95 percent CI 6.2-12.5, p-value is less than 0.0001), respectively. All adverse symptoms, except for palpitations, were reduced at the end of the study. Conclusion: Lercanidipine is efficacious and well tolerated in Asians of different ethnicities. Its BP lowering effects and tolerability in Asians appear to be similar to other studies on Caucasians and other calcium channel blockers.
format Article
author Chia, Yook Chin
Yeoh, E.S.H.
Ng, C.J.
Khoo, E.M.
Chua, C.T.
author_facet Chia, Yook Chin
Yeoh, E.S.H.
Ng, C.J.
Khoo, E.M.
Chua, C.T.
author_sort Chia, Yook Chin
title Efficacy and tolerability of lercanidipine in mild to moderate hypertension among Asians of different ethnic groups
title_short Efficacy and tolerability of lercanidipine in mild to moderate hypertension among Asians of different ethnic groups
title_full Efficacy and tolerability of lercanidipine in mild to moderate hypertension among Asians of different ethnic groups
title_fullStr Efficacy and tolerability of lercanidipine in mild to moderate hypertension among Asians of different ethnic groups
title_full_unstemmed Efficacy and tolerability of lercanidipine in mild to moderate hypertension among Asians of different ethnic groups
title_sort efficacy and tolerability of lercanidipine in mild to moderate hypertension among asians of different ethnic groups
publisher Stamford Publishing Pte Ltd / Singapore Medical Association
publishDate 2009
url http://eprints.um.edu.my/1115/1/Efficacy_and_tolerability_of_lercanidipine_in_mild_to_moderate_hyperetnsion_Chia_YC_SMJ_2009.pdf
http://eprints.um.edu.my/1115/
http://smj.sma.org.sg/5005/5005a8.pdf
_version_ 1674066707277152256
score 13.211869

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