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Childhood invasive pneumococcal disease: a hospital-based study from Malaysia

Aim: New conjugate vaccine for Streptococcus pneumoniae has been introduced in Malaysia recently. Information on infection due to S. pneumoniae in Malaysian children is scarce. We conducted a retrospective chart review of childhood invasive pneumococcal disease (IPD) presented to a single centre in...

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Main Authors: Lim, L.H., Lee, Way Seah, Parasakthi, N.
Format: Article
Published: Wiley 2007
Subjects:
R Medicine
RJ Pediatrics
Online Access:http://eprints.um.edu.my/10896/
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1754.2007.01081.x/full
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spelling my.um.eprints.108962019-02-25T07:58:16Z http://eprints.um.edu.my/10896/ Childhood invasive pneumococcal disease: a hospital-based study from Malaysia Lim, L.H. Lee, Way Seah Parasakthi, N. R Medicine RJ Pediatrics Aim: New conjugate vaccine for Streptococcus pneumoniae has been introduced in Malaysia recently. Information on infection due to S. pneumoniae in Malaysian children is scarce. We conducted a retrospective chart review of childhood invasive pneumococcal disease (IPD) presented to a single centre in Malaysia. Methods: A retrospective review of 5 years and 4 months of all cases of IPD in children younger than 14 years of age (May 1999-August 2004) seen at the University of Malaya Medical Centre (UMMC), Kuala Lumpur, was conducted. Cases were identified from the record of Department of Medical Microbiology, UMMC. Results: IPD was identified in 50 children (median age 1.1 years, range 2 weeks-14 years) during the study period. Seventy-six per cent of the cases were younger than 2 years of age. Pattern of infections noted include definite pneumonia (n = 8), probable pneumonia (n = 33), meningitis (n = 4), bacteraemia without focus (n = 4) and septic arthritis (n = 1 each). Pre-morbid diseases were present in 28 of all cases. Complications (n = 12, 24) due to IPD were seizures (n = 5), pleural effusion/empyema (n = 4), cerebral palsy (n = 2) and deafness (n = 1). No deaths were attributed to IPD. Sixty-two per cent of the pneumococcal isolates were penicillin non-susceptible and were detected throughout the study period. Conclusions: IPD is associated with high morbidity, particularly among young children. Majority of the isolates were penicillin-non-susceptible strains. Additional information on the serotype of S. pneumoniae isolated is necessary to assess the potential impact of immunisation on preventing pneumococcal infection in Malaysia. Wiley 2007 Article PeerReviewed Lim, L.H. and Lee, Way Seah and Parasakthi, N. (2007) Childhood invasive pneumococcal disease: a hospital-based study from Malaysia. Journal of Paediatrics and Child Health, 43 (5). pp. 366-369. ISSN 1034-4810 http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1754.2007.01081.x/full 10.1111/j.1440-1754.2007.01081.x
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
RJ Pediatrics
spellingShingle R Medicine
RJ Pediatrics
Lim, L.H.
Lee, Way Seah
Parasakthi, N.
Childhood invasive pneumococcal disease: a hospital-based study from Malaysia
description Aim: New conjugate vaccine for Streptococcus pneumoniae has been introduced in Malaysia recently. Information on infection due to S. pneumoniae in Malaysian children is scarce. We conducted a retrospective chart review of childhood invasive pneumococcal disease (IPD) presented to a single centre in Malaysia. Methods: A retrospective review of 5 years and 4 months of all cases of IPD in children younger than 14 years of age (May 1999-August 2004) seen at the University of Malaya Medical Centre (UMMC), Kuala Lumpur, was conducted. Cases were identified from the record of Department of Medical Microbiology, UMMC. Results: IPD was identified in 50 children (median age 1.1 years, range 2 weeks-14 years) during the study period. Seventy-six per cent of the cases were younger than 2 years of age. Pattern of infections noted include definite pneumonia (n = 8), probable pneumonia (n = 33), meningitis (n = 4), bacteraemia without focus (n = 4) and septic arthritis (n = 1 each). Pre-morbid diseases were present in 28 of all cases. Complications (n = 12, 24) due to IPD were seizures (n = 5), pleural effusion/empyema (n = 4), cerebral palsy (n = 2) and deafness (n = 1). No deaths were attributed to IPD. Sixty-two per cent of the pneumococcal isolates were penicillin non-susceptible and were detected throughout the study period. Conclusions: IPD is associated with high morbidity, particularly among young children. Majority of the isolates were penicillin-non-susceptible strains. Additional information on the serotype of S. pneumoniae isolated is necessary to assess the potential impact of immunisation on preventing pneumococcal infection in Malaysia.
format Article
author Lim, L.H.
Lee, Way Seah
Parasakthi, N.
author_facet Lim, L.H.
Lee, Way Seah
Parasakthi, N.
author_sort Lim, L.H.
title Childhood invasive pneumococcal disease: a hospital-based study from Malaysia
title_short Childhood invasive pneumococcal disease: a hospital-based study from Malaysia
title_full Childhood invasive pneumococcal disease: a hospital-based study from Malaysia
title_fullStr Childhood invasive pneumococcal disease: a hospital-based study from Malaysia
title_full_unstemmed Childhood invasive pneumococcal disease: a hospital-based study from Malaysia
title_sort childhood invasive pneumococcal disease: a hospital-based study from malaysia
publisher Wiley
publishDate 2007
url http://eprints.um.edu.my/10896/
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1754.2007.01081.x/full
_version_ 1643688912928899072
score 13.211869

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