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Lack of association between TYK2 and STAT3 genes and Crohn's disease in the Malaysian population

This study aimed to investigate the potential association of TYK2 and STAT3 genes with the susceptibility to Crohn's disease (CD) among Malaysians. DNA samples were obtained from 80 CD patients and 100 healthy controls. Polymerase chain reaction-restriction fragment length polymorphism methods...

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Main Authors: Lian, L.H., Lau, T.P., Lee, V.L., Lee, W.S., Hilmi, I., Goh, K.L., Chua, K.H.
Format: Article
Language:English
Published: 2013
Subjects:
R Medicine
RJ Pediatrics
Online Access:http://eprints.um.edu.my/10874/1/Lian-2013-Lack_of_association.pdf
http://eprints.um.edu.my/10874/
http://www.funpecrp.com.br/gmr/year2013/vol12-1/pdf/gmr2091.pdf
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spelling my.um.eprints.108742014-07-13T06:38:41Z http://eprints.um.edu.my/10874/ Lack of association between TYK2 and STAT3 genes and Crohn's disease in the Malaysian population Lian, L.H. Lau, T.P. Lee, V.L. Lee, W.S. Hilmi, I. Goh, K.L. Chua, K.H. R Medicine RJ Pediatrics This study aimed to investigate the potential association of TYK2 and STAT3 genes with the susceptibility to Crohn's disease (CD) among Malaysians. DNA samples were obtained from 80 CD patients and 100 healthy controls. Polymerase chain reaction-restriction fragment length polymorphism methods were employed for genotyping, followed by statistical analysis. In our current study, none of the single nucleotide polymorphisms of either TYK2 or STAT3 was statistically associated with the susceptibility to CD in our local population (P > 0.05). In contrast, there was a statistically significant association between the G/G homozygotes of the STAT3 rs2293152 and the healthy control group (chi(2) = 6.229, P < 0.05). In conclusion, our study does not support the role of the TYK2 and STAT3 genes influencing CD susceptibility. 2013 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10874/1/Lian-2013-Lack_of_association.pdf Lian, L.H. and Lau, T.P. and Lee, V.L. and Lee, W.S. and Hilmi, I. and Goh, K.L. and Chua, K.H. (2013) Lack of association between TYK2 and STAT3 genes and Crohn's disease in the Malaysian population. Genetics and Molecular Research, 12 (1). pp. 167-174. ISSN 1676-5680 http://www.funpecrp.com.br/gmr/year2013/vol12-1/pdf/gmr2091.pdf 10.4238/2013.January.24.9
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine
RJ Pediatrics
spellingShingle R Medicine
RJ Pediatrics
Lian, L.H.
Lau, T.P.
Lee, V.L.
Lee, W.S.
Hilmi, I.
Goh, K.L.
Chua, K.H.
Lack of association between TYK2 and STAT3 genes and Crohn's disease in the Malaysian population
description This study aimed to investigate the potential association of TYK2 and STAT3 genes with the susceptibility to Crohn's disease (CD) among Malaysians. DNA samples were obtained from 80 CD patients and 100 healthy controls. Polymerase chain reaction-restriction fragment length polymorphism methods were employed for genotyping, followed by statistical analysis. In our current study, none of the single nucleotide polymorphisms of either TYK2 or STAT3 was statistically associated with the susceptibility to CD in our local population (P > 0.05). In contrast, there was a statistically significant association between the G/G homozygotes of the STAT3 rs2293152 and the healthy control group (chi(2) = 6.229, P < 0.05). In conclusion, our study does not support the role of the TYK2 and STAT3 genes influencing CD susceptibility.
format Article
author Lian, L.H.
Lau, T.P.
Lee, V.L.
Lee, W.S.
Hilmi, I.
Goh, K.L.
Chua, K.H.
author_facet Lian, L.H.
Lau, T.P.
Lee, V.L.
Lee, W.S.
Hilmi, I.
Goh, K.L.
Chua, K.H.
author_sort Lian, L.H.
title Lack of association between TYK2 and STAT3 genes and Crohn's disease in the Malaysian population
title_short Lack of association between TYK2 and STAT3 genes and Crohn's disease in the Malaysian population
title_full Lack of association between TYK2 and STAT3 genes and Crohn's disease in the Malaysian population
title_fullStr Lack of association between TYK2 and STAT3 genes and Crohn's disease in the Malaysian population
title_full_unstemmed Lack of association between TYK2 and STAT3 genes and Crohn's disease in the Malaysian population
title_sort lack of association between tyk2 and stat3 genes and crohn's disease in the malaysian population
publishDate 2013
url http://eprints.um.edu.my/10874/1/Lian-2013-Lack_of_association.pdf
http://eprints.um.edu.my/10874/
http://www.funpecrp.com.br/gmr/year2013/vol12-1/pdf/gmr2091.pdf
_version_ 1643688908791218176
score 13.211869

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