Effects of growing-up milk supplemented with prebiotics and LCPUFAs on infections in young children
Objective: The aim of this study was to investigate the effect of growing-up milk (GUM) with added short-chain galacto-oligosaccharides (scGOS)/long-chain fructo-oligosaccharides (lcFOS) (9:1) (Immunofortis) and n-3 long-chain polyunsaturated fatty acids (LCPUFAs) on the occurrence of infections in...
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Lippincott, Williams & Wilkins
2014
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my.um.eprints.108732019-03-21T06:48:15Z http://eprints.um.edu.my/10873/ Effects of growing-up milk supplemented with prebiotics and LCPUFAs on infections in young children Chatchatee, P. Lee, Way Seah Carrilho, E. Kosuwon, P. Simakachorn, N. Yavuz, Y. Schouten, B. Logtens-de Graaff, P. Szajewska, H. R Medicine Child health. Child health services Objective: The aim of this study was to investigate the effect of growing-up milk (GUM) with added short-chain galacto-oligosaccharides (scGOS)/long-chain fructo-oligosaccharides (lcFOS) (9:1) (Immunofortis) and n-3 long-chain polyunsaturated fatty acids (LCPUFAs) on the occurrence of infections in healthy children attending day care centres. Methods: In a randomised double-blind controlled, parallel, multicountry intervention study, 767 healthy children, ages 11 to 29 months, received GUM with scGOS/lcFOS/LCPUFAs (the active group, n = 388), GUM without scGOS/lcFOS/LCPUFAs (the control group, n = 379), or cow's milk (n = 37) for 52 weeks. The primary outcome measure was the number of episodes of upper respiratory tract infections or gastrointestinal infections based on a combination of subject's illness symptoms reported by the parents during the intervention period. Results: Children in the active group compared with the control group had a decreased risk of developing at least 1 infection (299/388 77% vs 313/379 83%, respectively, relative risk 0.93, 95% confidence interval CI 0.87-1.00; logistic regression P = 0.03). There was a trend toward a reduction (P = 0.07) in the total number of infections in the active group, which was significant when confirmed by one of the investigators (268/388 69% vs 293/379 77%, respectively, relative risk 0.89, 95% CI 0.82-0.97; P = 0.004, post hoc). More infectious episodes were observed in the cow's milk group, when compared with both GUM groups (34/37 92% vs 612/767 80%, respectively, relative risk 1.15, 95% CI 1.04-1.28). Conclusions: This is the first study in children to show a reduced risk of infection following consumption of GUM supplemented with scGOS/lcFOS/n-3 LCPUFAs. The borderline statistical significance justifies a new study to confirm this finding. Lippincott, Williams & Wilkins 2014 Article PeerReviewed Chatchatee, P. and Lee, Way Seah and Carrilho, E. and Kosuwon, P. and Simakachorn, N. and Yavuz, Y. and Schouten, B. and Logtens-de Graaff, P. and Szajewska, H. (2014) Effects of growing-up milk supplemented with prebiotics and LCPUFAs on infections in young children. Journal of Pediatric Gastroenterology and Nutrition, 58 (4). pp. 428-437. ISSN 0277-2116 http://journals.lww.com/jpgn/Abstract/2014/04000/Effects_of_Growing_Up_Milk_Supplemented_With.11.aspx 10.1097/mpg.0000000000000252 |
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R Medicine Child health. Child health services Chatchatee, P. Lee, Way Seah Carrilho, E. Kosuwon, P. Simakachorn, N. Yavuz, Y. Schouten, B. Logtens-de Graaff, P. Szajewska, H. Effects of growing-up milk supplemented with prebiotics and LCPUFAs on infections in young children |
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Objective: The aim of this study was to investigate the effect of growing-up milk (GUM) with added short-chain galacto-oligosaccharides (scGOS)/long-chain fructo-oligosaccharides (lcFOS) (9:1) (Immunofortis) and n-3 long-chain polyunsaturated fatty acids (LCPUFAs) on the occurrence of infections in healthy children attending day care centres. Methods: In a randomised double-blind controlled, parallel, multicountry intervention study, 767 healthy children, ages 11 to 29 months, received GUM with scGOS/lcFOS/LCPUFAs (the active group, n = 388), GUM without scGOS/lcFOS/LCPUFAs (the control group, n = 379), or cow's milk (n = 37) for 52 weeks. The primary outcome measure was the number of episodes of upper respiratory tract infections or gastrointestinal infections based on a combination of subject's illness symptoms reported by the parents during the intervention period. Results: Children in the active group compared with the control group had a decreased risk of developing at least 1 infection (299/388 77% vs 313/379 83%, respectively, relative risk 0.93, 95% confidence interval CI 0.87-1.00; logistic regression P = 0.03). There was a trend toward a reduction (P = 0.07) in the total number of infections in the active group, which was significant when confirmed by one of the investigators (268/388 69% vs 293/379 77%, respectively, relative risk 0.89, 95% CI 0.82-0.97; P = 0.004, post hoc). More infectious episodes were observed in the cow's milk group, when compared with both GUM groups (34/37 92% vs 612/767 80%, respectively, relative risk 1.15, 95% CI 1.04-1.28). Conclusions: This is the first study in children to show a reduced risk of infection following consumption of GUM supplemented with scGOS/lcFOS/n-3 LCPUFAs. The borderline statistical significance justifies a new study to confirm this finding. |
| format |
Article |
| author |
Chatchatee, P. Lee, Way Seah Carrilho, E. Kosuwon, P. Simakachorn, N. Yavuz, Y. Schouten, B. Logtens-de Graaff, P. Szajewska, H. |
| author_facet |
Chatchatee, P. Lee, Way Seah Carrilho, E. Kosuwon, P. Simakachorn, N. Yavuz, Y. Schouten, B. Logtens-de Graaff, P. Szajewska, H. |
| author_sort |
Chatchatee, P. |
| title |
Effects of growing-up milk supplemented with prebiotics and LCPUFAs on infections in young children |
| title_short |
Effects of growing-up milk supplemented with prebiotics and LCPUFAs on infections in young children |
| title_full |
Effects of growing-up milk supplemented with prebiotics and LCPUFAs on infections in young children |
| title_fullStr |
Effects of growing-up milk supplemented with prebiotics and LCPUFAs on infections in young children |
| title_full_unstemmed |
Effects of growing-up milk supplemented with prebiotics and LCPUFAs on infections in young children |
| title_sort |
effects of growing-up milk supplemented with prebiotics and lcpufas on infections in young children |
| publisher |
Lippincott, Williams & Wilkins |
| publishDate |
2014 |
| url |
http://eprints.um.edu.my/10873/ http://journals.lww.com/jpgn/Abstract/2014/04000/Effects_of_Growing_Up_Milk_Supplemented_With.11.aspx |
| _version_ |
1643688908497616896 |
| score |
13.211869 |