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Whole-Genome Sequences and Comparative Genomics of Salmonella enterica Serovar Typhi Isolates from Patients with Fatal and Nonfatal Typhoid Fever in Papua New Guinea

Many of the developing countries of the Southeast Asian region are significantly affected by endemic typhoid fever, possibly as a result of marginal living standards. It is an important public health problem in countries such as Papua New Guinea, which is geographically close to some of the foci of...

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Main Authors: Baddam, Ramani, Thong, Kwai Lin, Avasthi, Tiruvayipati Suma, Shaik, Sabiha, Yap, Kien Pong, Teh, Cindy Shuan Ju, Chai, Lay Ching, Kumarasamy, Narender, Ahmed, Niyaz
Format: Article
Language:English
Published: American Society for Microbiology 2012
Subjects:
Q Science (General)
QH Natural history
QR Microbiology
Online Access:http://eprints.um.edu.my/10643/1/00004462_82648.pdf
http://eprints.um.edu.my/10643/
https://doi.org/10.1128/JB.01051-12
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spelling my.um.eprints.106432019-12-03T04:29:02Z http://eprints.um.edu.my/10643/ Whole-Genome Sequences and Comparative Genomics of Salmonella enterica Serovar Typhi Isolates from Patients with Fatal and Nonfatal Typhoid Fever in Papua New Guinea Baddam, Ramani Thong, Kwai Lin Avasthi, Tiruvayipati Suma Shaik, Sabiha Yap, Kien Pong Teh, Cindy Shuan Ju Chai, Lay Ching Kumarasamy, Narender Ahmed, Niyaz Q Science (General) QH Natural history QR Microbiology Many of the developing countries of the Southeast Asian region are significantly affected by endemic typhoid fever, possibly as a result of marginal living standards. It is an important public health problem in countries such as Papua New Guinea, which is geographically close to some of the foci of endemicity in Asia. The severity of the disease varies in different regions, and this may be attributable to genetic diversity among the native strains. Genome sequence data on strains from different countries are needed to clearly understand their genetic makeup and virulence potential. We describe the genomes of two Salmonella Typhi isolates from patients with fatal and nonfatal cases of typhoid fever in Papua New Guinea. We discuss in brief the underlying sequencing methodology, assembly, genome statistics, and important features of the two draft genomes, which form an essential step in our functional molecular infection epidemiology program centering on typhoid fever. The comparative genomics of these and other isolates would enable us to identify genetic rearrangements and mechanisms responsible for endemicity and the differential severity of pathogenic salmonellae in Papua New Guinea and elsewhere. American Society for Microbiology 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10643/1/00004462_82648.pdf Baddam, Ramani and Thong, Kwai Lin and Avasthi, Tiruvayipati Suma and Shaik, Sabiha and Yap, Kien Pong and Teh, Cindy Shuan Ju and Chai, Lay Ching and Kumarasamy, Narender and Ahmed, Niyaz (2012) Whole-Genome Sequences and Comparative Genomics of Salmonella enterica Serovar Typhi Isolates from Patients with Fatal and Nonfatal Typhoid Fever in Papua New Guinea. Journal of Bacteriology, 194 (18). pp. 5122-5123. ISSN 0021-9193 https://doi.org/10.1128/JB.01051-12 doi:10.1128/JB.01051-12
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic Q Science (General)
QH Natural history
QR Microbiology
spellingShingle Q Science (General)
QH Natural history
QR Microbiology
Baddam, Ramani
Thong, Kwai Lin
Avasthi, Tiruvayipati Suma
Shaik, Sabiha
Yap, Kien Pong
Teh, Cindy Shuan Ju
Chai, Lay Ching
Kumarasamy, Narender
Ahmed, Niyaz
Whole-Genome Sequences and Comparative Genomics of Salmonella enterica Serovar Typhi Isolates from Patients with Fatal and Nonfatal Typhoid Fever in Papua New Guinea
description Many of the developing countries of the Southeast Asian region are significantly affected by endemic typhoid fever, possibly as a result of marginal living standards. It is an important public health problem in countries such as Papua New Guinea, which is geographically close to some of the foci of endemicity in Asia. The severity of the disease varies in different regions, and this may be attributable to genetic diversity among the native strains. Genome sequence data on strains from different countries are needed to clearly understand their genetic makeup and virulence potential. We describe the genomes of two Salmonella Typhi isolates from patients with fatal and nonfatal cases of typhoid fever in Papua New Guinea. We discuss in brief the underlying sequencing methodology, assembly, genome statistics, and important features of the two draft genomes, which form an essential step in our functional molecular infection epidemiology program centering on typhoid fever. The comparative genomics of these and other isolates would enable us to identify genetic rearrangements and mechanisms responsible for endemicity and the differential severity of pathogenic salmonellae in Papua New Guinea and elsewhere.
format Article
author Baddam, Ramani
Thong, Kwai Lin
Avasthi, Tiruvayipati Suma
Shaik, Sabiha
Yap, Kien Pong
Teh, Cindy Shuan Ju
Chai, Lay Ching
Kumarasamy, Narender
Ahmed, Niyaz
author_facet Baddam, Ramani
Thong, Kwai Lin
Avasthi, Tiruvayipati Suma
Shaik, Sabiha
Yap, Kien Pong
Teh, Cindy Shuan Ju
Chai, Lay Ching
Kumarasamy, Narender
Ahmed, Niyaz
author_sort Baddam, Ramani
title Whole-Genome Sequences and Comparative Genomics of Salmonella enterica Serovar Typhi Isolates from Patients with Fatal and Nonfatal Typhoid Fever in Papua New Guinea
title_short Whole-Genome Sequences and Comparative Genomics of Salmonella enterica Serovar Typhi Isolates from Patients with Fatal and Nonfatal Typhoid Fever in Papua New Guinea
title_full Whole-Genome Sequences and Comparative Genomics of Salmonella enterica Serovar Typhi Isolates from Patients with Fatal and Nonfatal Typhoid Fever in Papua New Guinea
title_fullStr Whole-Genome Sequences and Comparative Genomics of Salmonella enterica Serovar Typhi Isolates from Patients with Fatal and Nonfatal Typhoid Fever in Papua New Guinea
title_full_unstemmed Whole-Genome Sequences and Comparative Genomics of Salmonella enterica Serovar Typhi Isolates from Patients with Fatal and Nonfatal Typhoid Fever in Papua New Guinea
title_sort whole-genome sequences and comparative genomics of salmonella enterica serovar typhi isolates from patients with fatal and nonfatal typhoid fever in papua new guinea
publisher American Society for Microbiology
publishDate 2012
url http://eprints.um.edu.my/10643/1/00004462_82648.pdf
http://eprints.um.edu.my/10643/
https://doi.org/10.1128/JB.01051-12
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score 13.211869

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