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Epidermal growth factor receptor mutations in lung adenocarcinoma in Malaysian patients

Despite available data from other Asian countries, the prevalence of epidermal growth factor receptor (EGFR) mutations among lung adenocarcinoma patients has not been reported in Malaysia. This study sought to determine the frequency of EGFR mutations among multiethnic Malaysian patients diagnosed w...

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Main Authors: Liam, C.K., Wahid, M.I.A., Pathmanathan, R, Cheah, Y.K., Ng, T.S.Y.
Format: Article
Language:English
Published: International Association for the Study of Lung Cancer 2013
Subjects:
R Medicine (General)
Online Access:http://eprints.um.edu.my/10617/1/Epidermal_Growth_Factor_Receptor_Mutations_in_Lung.pdf
http://eprints.um.edu.my/10617/
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spelling my.um.eprints.106172014-06-16T09:18:51Z http://eprints.um.edu.my/10617/ Epidermal growth factor receptor mutations in lung adenocarcinoma in Malaysian patients Liam, C.K. Wahid, M.I.A. Pathmanathan, R Cheah, Y.K. Ng, T.S.Y. R Medicine (General) Despite available data from other Asian countries, the prevalence of epidermal growth factor receptor (EGFR) mutations among lung adenocarcinoma patients has not been reported in Malaysia. This study sought to determine the frequency of EGFR mutations among multiethnic Malaysian patients diagnosed with lung adenocarcinoma. Demographic and clinical information of patients whose lung adenocarcinoma biopsy specimens were submitted for EGFR mutation testing at Sime Darby Medical Center from 2009 to 2011 were analyzed. EGFR mutations at exons 18, 19, 20, and 21 were detected either through bidirectional sequencing or real-time polymerase chain reaction. Among 812 patients in the study, 49% were female, 63.7% were ethnic Chinese, 29.4% Malay, 4.8% Indian, and 2.1% other ethnic groups. Mutations were present in the tumors of 321 patients (39.5%), with mutations at exons 19 (23.5%) and 21 (14.9%) being the most common. Mutations were significantly more frequent among women than in men (52.5% versus 27.8%, p < 0.001). Although mutations were more common among Chinese (40.8%) compared with Malay (37.2%) or Indian (33.3%) patients, the difference was not statistically significant (p = 0.591). Of 211 patients with smoking history records, never-smokers had a higher mutation rate compared with ever-smokers (54.8% versus 20.7%, p < 0.001). EGFR mutations were present in 39.5% of patients. Mutations were more common in women and never-smokers with no differences in mutation frequency between different ethnicities. Because of the high mutation rates, reflex testing for EGFR mutation should be a routine practice for advanced lung adenocarcinoma patients in Malaysia. International Association for the Study of Lung Cancer 2013 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10617/1/Epidermal_Growth_Factor_Receptor_Mutations_in_Lung.pdf Liam, C.K. and Wahid, M.I.A. and Pathmanathan, R and Cheah, Y.K. and Ng, T.S.Y. (2013) Epidermal growth factor receptor mutations in lung adenocarcinoma in Malaysian patients. Journal of Thoracic Oncology, 8 (6). pp. 766-772. ISSN 1556-0864
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Liam, C.K.
Wahid, M.I.A.
Pathmanathan, R
Cheah, Y.K.
Ng, T.S.Y.
Epidermal growth factor receptor mutations in lung adenocarcinoma in Malaysian patients
description Despite available data from other Asian countries, the prevalence of epidermal growth factor receptor (EGFR) mutations among lung adenocarcinoma patients has not been reported in Malaysia. This study sought to determine the frequency of EGFR mutations among multiethnic Malaysian patients diagnosed with lung adenocarcinoma. Demographic and clinical information of patients whose lung adenocarcinoma biopsy specimens were submitted for EGFR mutation testing at Sime Darby Medical Center from 2009 to 2011 were analyzed. EGFR mutations at exons 18, 19, 20, and 21 were detected either through bidirectional sequencing or real-time polymerase chain reaction. Among 812 patients in the study, 49% were female, 63.7% were ethnic Chinese, 29.4% Malay, 4.8% Indian, and 2.1% other ethnic groups. Mutations were present in the tumors of 321 patients (39.5%), with mutations at exons 19 (23.5%) and 21 (14.9%) being the most common. Mutations were significantly more frequent among women than in men (52.5% versus 27.8%, p < 0.001). Although mutations were more common among Chinese (40.8%) compared with Malay (37.2%) or Indian (33.3%) patients, the difference was not statistically significant (p = 0.591). Of 211 patients with smoking history records, never-smokers had a higher mutation rate compared with ever-smokers (54.8% versus 20.7%, p < 0.001). EGFR mutations were present in 39.5% of patients. Mutations were more common in women and never-smokers with no differences in mutation frequency between different ethnicities. Because of the high mutation rates, reflex testing for EGFR mutation should be a routine practice for advanced lung adenocarcinoma patients in Malaysia.
format Article
author Liam, C.K.
Wahid, M.I.A.
Pathmanathan, R
Cheah, Y.K.
Ng, T.S.Y.
author_facet Liam, C.K.
Wahid, M.I.A.
Pathmanathan, R
Cheah, Y.K.
Ng, T.S.Y.
author_sort Liam, C.K.
title Epidermal growth factor receptor mutations in lung adenocarcinoma in Malaysian patients
title_short Epidermal growth factor receptor mutations in lung adenocarcinoma in Malaysian patients
title_full Epidermal growth factor receptor mutations in lung adenocarcinoma in Malaysian patients
title_fullStr Epidermal growth factor receptor mutations in lung adenocarcinoma in Malaysian patients
title_full_unstemmed Epidermal growth factor receptor mutations in lung adenocarcinoma in Malaysian patients
title_sort epidermal growth factor receptor mutations in lung adenocarcinoma in malaysian patients
publisher International Association for the Study of Lung Cancer
publishDate 2013
url http://eprints.um.edu.my/10617/1/Epidermal_Growth_Factor_Receptor_Mutations_in_Lung.pdf
http://eprints.um.edu.my/10617/
_version_ 1643688846258339840
score 13.211869

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