Cover Image

A comparison of wound healing rate following treatment with aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats

Background and Purpose. This study aimed to evaluate the wound healing activities of Aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats. Experimental Approach. Forty-eight Sprague Dawley rats were chosen for this study, divided into 4 groups. Diabetes was induced. Two-centimet...

Full description

Saved in:
Bibliographic Details
Main Authors: Al-Bayaty, Fouad, Abdulla, Mahmood Ameen
Format: Article
Language:English
Published: Hindawi 2012
Subjects:
R Medicine (General)
Online Access:http://eprints.um.edu.my/10556/1/A_comparison_of_wound_healing_rate_following_treatment_with_aftamed_and_chlorine_dioxide_gels_in_streptozotocin-induced_diabetic_rats.pdf
http://eprints.um.edu.my/10556/
http://www.hindawi.com/journals/ecam/2012/468764/
http://dx.doi.org/10.1155/2012/468764
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.um.eprints.10556
record_format eprints
spelling my.um.eprints.105562020-01-29T06:18:00Z http://eprints.um.edu.my/10556/ A comparison of wound healing rate following treatment with aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats Al-Bayaty, Fouad Abdulla, Mahmood Ameen R Medicine (General) Background and Purpose. This study aimed to evaluate the wound healing activities of Aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats. Experimental Approach. Forty-eight Sprague Dawley rats were chosen for this study, divided into 4 groups. Diabetes was induced. Two-centimeter-diameter full-thickness skin excision wounds were created. Animals were topically treated twice daily. Groups 1, the diabetic control group, were treated with 0.2mL of sterile distilled water. Group 2 served as a reference standard were treated with 0.2mL of Intrasite gel. Groups 3 and 4 were treated with 0.2mL of Aftamed and 0.2mL of chlorine dioxide gels respectively. Granulation tissue was excised on the 10th day and processed for histological and biochemical analysis. The glutathione peroxidase ,superoxide dismutase activities and the malondialdehyde (MDA) levels were determined. Results. Aftamed-treated wounds exhibited significant increases in hydroxyproline, cellular proliferation, the number of blood vessels, and the level of collagen synthesis. Aftamed induced an increase in the free radical-scavenging enzyme activity and significantly reduced the lipid peroxidation levels in the wounds as measured by the reduction in theMDA level. Conclusions. This study showed that Aftamed gel is able to significantly accelerate the process of wound healing in diabetic rats. Hindawi 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10556/1/A_comparison_of_wound_healing_rate_following_treatment_with_aftamed_and_chlorine_dioxide_gels_in_streptozotocin-induced_diabetic_rats.pdf Al-Bayaty, Fouad and Abdulla, Mahmood Ameen (2012) A comparison of wound healing rate following treatment with aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats. Evidence-Based Complementary and Alternative Medicine, 2012. p. 468764. ISSN 1741-427X http://www.hindawi.com/journals/ecam/2012/468764/ http://dx.doi.org/10.1155/2012/468764
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Al-Bayaty, Fouad
Abdulla, Mahmood Ameen
A comparison of wound healing rate following treatment with aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats
description Background and Purpose. This study aimed to evaluate the wound healing activities of Aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats. Experimental Approach. Forty-eight Sprague Dawley rats were chosen for this study, divided into 4 groups. Diabetes was induced. Two-centimeter-diameter full-thickness skin excision wounds were created. Animals were topically treated twice daily. Groups 1, the diabetic control group, were treated with 0.2mL of sterile distilled water. Group 2 served as a reference standard were treated with 0.2mL of Intrasite gel. Groups 3 and 4 were treated with 0.2mL of Aftamed and 0.2mL of chlorine dioxide gels respectively. Granulation tissue was excised on the 10th day and processed for histological and biochemical analysis. The glutathione peroxidase ,superoxide dismutase activities and the malondialdehyde (MDA) levels were determined. Results. Aftamed-treated wounds exhibited significant increases in hydroxyproline, cellular proliferation, the number of blood vessels, and the level of collagen synthesis. Aftamed induced an increase in the free radical-scavenging enzyme activity and significantly reduced the lipid peroxidation levels in the wounds as measured by the reduction in theMDA level. Conclusions. This study showed that Aftamed gel is able to significantly accelerate the process of wound healing in diabetic rats.
format Article
author Al-Bayaty, Fouad
Abdulla, Mahmood Ameen
author_facet Al-Bayaty, Fouad
Abdulla, Mahmood Ameen
author_sort Al-Bayaty, Fouad
title A comparison of wound healing rate following treatment with aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats
title_short A comparison of wound healing rate following treatment with aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats
title_full A comparison of wound healing rate following treatment with aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats
title_fullStr A comparison of wound healing rate following treatment with aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats
title_full_unstemmed A comparison of wound healing rate following treatment with aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats
title_sort comparison of wound healing rate following treatment with aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats
publisher Hindawi
publishDate 2012
url http://eprints.um.edu.my/10556/1/A_comparison_of_wound_healing_rate_following_treatment_with_aftamed_and_chlorine_dioxide_gels_in_streptozotocin-induced_diabetic_rats.pdf
http://eprints.um.edu.my/10556/
http://www.hindawi.com/journals/ecam/2012/468764/
http://dx.doi.org/10.1155/2012/468764
_version_ 1657488175944171520
score 13.223943

Similar Items