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A schiff base-derived copper (II) complex is a potent inducer of apoptosis in colon cancer cells by activating the intrinsic pathway

Metal-based drugs with extensive clinical applications hold great promise for the development of cancer chemotherapeutic agents. In the last few decades, Schiff bases and their complexes have become well known for their extensive biological potential. In the present study, we examined the antiprolif...

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Main Authors: Hajrezaie, M., Paydar, M., Moghadamtousi, S.Z., Hassandarvish, P., Gwaram, N.S., Zahedifard, M., Rouhollah, E., Karimian, H., Looi, C.Y., Ali, H.M., Majid, N.A., Abdulla, M.A.
Format: Article
Language:English
Published: Hindawi Publishing Corporation 2014
Subjects:
QD Chemistry
Online Access:http://eprints.um.edu.my/10529/1/A_Schiff_Base-Derived_Copper_%28II%29_Complex_Is.pdf
http://eprints.um.edu.my/10529/
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spelling my.um.eprints.105292014-11-11T04:24:55Z http://eprints.um.edu.my/10529/ A schiff base-derived copper (II) complex is a potent inducer of apoptosis in colon cancer cells by activating the intrinsic pathway Hajrezaie, M. Paydar, M. Moghadamtousi, S.Z. Hassandarvish, P. Gwaram, N.S. Zahedifard, M. Rouhollah, E. Karimian, H. Looi, C.Y. Ali, H.M. Majid, N.A. Abdulla, M.A. QD Chemistry Metal-based drugs with extensive clinical applications hold great promise for the development of cancer chemotherapeutic agents. In the last few decades, Schiff bases and their complexes have become well known for their extensive biological potential. In the present study, we examined the antiproliferative effect of a copper (II) complex on HT-29 colon cancer cells. The Cu(BrHAP)2 Schiff base compound demonstrated a potent tiproliferative effect in HT-29 cells, with an IC50 value of 2.87 Hindawi Publishing Corporation 2014 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10529/1/A_Schiff_Base-Derived_Copper_%28II%29_Complex_Is.pdf Hajrezaie, M. and Paydar, M. and Moghadamtousi, S.Z. and Hassandarvish, P. and Gwaram, N.S. and Zahedifard, M. and Rouhollah, E. and Karimian, H. and Looi, C.Y. and Ali, H.M. and Majid, N.A. and Abdulla, M.A. (2014) A schiff base-derived copper (II) complex is a potent inducer of apoptosis in colon cancer cells by activating the intrinsic pathway. Scientific World Journal.
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Hajrezaie, M.
Paydar, M.
Moghadamtousi, S.Z.
Hassandarvish, P.
Gwaram, N.S.
Zahedifard, M.
Rouhollah, E.
Karimian, H.
Looi, C.Y.
Ali, H.M.
Majid, N.A.
Abdulla, M.A.
A schiff base-derived copper (II) complex is a potent inducer of apoptosis in colon cancer cells by activating the intrinsic pathway
description Metal-based drugs with extensive clinical applications hold great promise for the development of cancer chemotherapeutic agents. In the last few decades, Schiff bases and their complexes have become well known for their extensive biological potential. In the present study, we examined the antiproliferative effect of a copper (II) complex on HT-29 colon cancer cells. The Cu(BrHAP)2 Schiff base compound demonstrated a potent tiproliferative effect in HT-29 cells, with an IC50 value of 2.87
format Article
author Hajrezaie, M.
Paydar, M.
Moghadamtousi, S.Z.
Hassandarvish, P.
Gwaram, N.S.
Zahedifard, M.
Rouhollah, E.
Karimian, H.
Looi, C.Y.
Ali, H.M.
Majid, N.A.
Abdulla, M.A.
author_facet Hajrezaie, M.
Paydar, M.
Moghadamtousi, S.Z.
Hassandarvish, P.
Gwaram, N.S.
Zahedifard, M.
Rouhollah, E.
Karimian, H.
Looi, C.Y.
Ali, H.M.
Majid, N.A.
Abdulla, M.A.
author_sort Hajrezaie, M.
title A schiff base-derived copper (II) complex is a potent inducer of apoptosis in colon cancer cells by activating the intrinsic pathway
title_short A schiff base-derived copper (II) complex is a potent inducer of apoptosis in colon cancer cells by activating the intrinsic pathway
title_full A schiff base-derived copper (II) complex is a potent inducer of apoptosis in colon cancer cells by activating the intrinsic pathway
title_fullStr A schiff base-derived copper (II) complex is a potent inducer of apoptosis in colon cancer cells by activating the intrinsic pathway
title_full_unstemmed A schiff base-derived copper (II) complex is a potent inducer of apoptosis in colon cancer cells by activating the intrinsic pathway
title_sort schiff base-derived copper (ii) complex is a potent inducer of apoptosis in colon cancer cells by activating the intrinsic pathway
publisher Hindawi Publishing Corporation
publishDate 2014
url http://eprints.um.edu.my/10529/1/A_Schiff_Base-Derived_Copper_%28II%29_Complex_Is.pdf
http://eprints.um.edu.my/10529/
_version_ 1643688825126387712
score 13.211869

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