Lumutinines A−D, linearly fused macroline−macroline and macroline−sarpagine bisindoles from alstonia macrophylla
Four new linearly fused bisindole alkaloids, lumutinines A−D (1−4), were isolated from the stem-bark extract of Alstonia macrophylla. Lumutinines A (1) and B (2) represent the first examples of linear, ring A/F-fused macroline−macroline-type bisindoles, while lumutinines C (3) and D (4) were consti...
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American Chemical Society and American Society of Pharmacognosy
2011
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my.um.eprints.103932014-10-15T01:51:06Z http://eprints.um.edu.my/10393/ Lumutinines A−D, linearly fused macroline−macroline and macroline−sarpagine bisindoles from alstonia macrophylla Kam, T.S. Lim, S.H. Tan, S.J. Low, Y.Y. QD Chemistry Four new linearly fused bisindole alkaloids, lumutinines A−D (1−4), were isolated from the stem-bark extract of Alstonia macrophylla. Lumutinines A (1) and B (2) represent the first examples of linear, ring A/F-fused macroline−macroline-type bisindoles, while lumutinines C (3) and D (4) were constituted from the union of macroline and sarpagine moieties. A reinvestigation of the stereochemical assignment of alstoumerine (8) by NMR and X-ray diffraction analyses indicated that the configuration at C-16 and C-19 required revision. American Chemical Society and American Society of Pharmacognosy 2011 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10393/1/Lumutinines_A%E2%88%92D%2C_linearly_fused_macroline%E2%88%92macroline_and.pdf Kam, T.S. and Lim, S.H. and Tan, S.J. and Low, Y.Y. (2011) Lumutinines A−D, linearly fused macroline−macroline and macroline−sarpagine bisindoles from alstonia macrophylla. Journal of Natural Products, 74. pp. 2556-2562. ISSN 0163-3864 DOI: 10.1021/np200730j |
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QD Chemistry Kam, T.S. Lim, S.H. Tan, S.J. Low, Y.Y. Lumutinines A−D, linearly fused macroline−macroline and macroline−sarpagine bisindoles from alstonia macrophylla |
| description |
Four new linearly fused bisindole alkaloids, lumutinines A−D (1−4), were isolated from the stem-bark extract of
Alstonia macrophylla. Lumutinines A (1) and B (2) represent the first examples of linear, ring A/F-fused macroline−macroline-type bisindoles, while lumutinines C (3) and D (4) were constituted from the union of macroline and sarpagine moieties. A reinvestigation of the stereochemical assignment of alstoumerine (8) by NMR and X-ray diffraction analyses indicated that the configuration at C-16 and C-19 required revision. |
| format |
Article |
| author |
Kam, T.S. Lim, S.H. Tan, S.J. Low, Y.Y. |
| author_facet |
Kam, T.S. Lim, S.H. Tan, S.J. Low, Y.Y. |
| author_sort |
Kam, T.S. |
| title |
Lumutinines A−D, linearly fused macroline−macroline and
macroline−sarpagine bisindoles from alstonia macrophylla |
| title_short |
Lumutinines A−D, linearly fused macroline−macroline and
macroline−sarpagine bisindoles from alstonia macrophylla |
| title_full |
Lumutinines A−D, linearly fused macroline−macroline and
macroline−sarpagine bisindoles from alstonia macrophylla |
| title_fullStr |
Lumutinines A−D, linearly fused macroline−macroline and
macroline−sarpagine bisindoles from alstonia macrophylla |
| title_full_unstemmed |
Lumutinines A−D, linearly fused macroline−macroline and
macroline−sarpagine bisindoles from alstonia macrophylla |
| title_sort |
lumutinines a−d, linearly fused macroline−macroline and
macroline−sarpagine bisindoles from alstonia macrophylla |
| publisher |
American Chemical Society and American Society of Pharmacognosy |
| publishDate |
2011 |
| url |
http://eprints.um.edu.my/10393/1/Lumutinines_A%E2%88%92D%2C_linearly_fused_macroline%E2%88%92macroline_and.pdf http://eprints.um.edu.my/10393/ |
| _version_ |
1643688788208123904 |
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13.211869 |