Staff View: Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia

Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia

The galloylated cyanogenic glucosides based on prunasin (1–7), gallotannins (8–14), ellagitannins (15–17), ellagic acid derivatives (18, 19) and gallic acid (20) isolated from the leaves of Phyllagathis rotundifolia (Melastomataceae) were investigated for their neuroprotective activity against hydro...

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Main Authors:	Tan, Hooi Poay, Wong, Daniel Zin Hua, Ling, Sui Kiong, Chuah, Cheng Hock, Kadir, Habsah Abdul
Format:	Article
Language:	English
Published:	Elsevier 2012
Subjects:	QD Chemistry QH Natural history
Online Access:	http://eprints.um.edu.my/10294/1/Neuroprotective_activity_of_galloylated_cyanogenic_glucosides_and.pdf http://eprints.um.edu.my/10294/ https://doi.org/10.1016/j.fitote.2011.10.019
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spelling	my.um.eprints.102942019-12-03T03:34:11Z http://eprints.um.edu.my/10294/ Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia Tan, Hooi Poay Wong, Daniel Zin Hua Ling, Sui Kiong Chuah, Cheng Hock Kadir, Habsah Abdul QD Chemistry QH Natural history The galloylated cyanogenic glucosides based on prunasin (1–7), gallotannins (8–14), ellagitannins (15–17), ellagic acid derivatives (18, 19) and gallic acid (20) isolated from the leaves of Phyllagathis rotundifolia (Melastomataceae) were investigated for their neuroprotective activity against hydrogen peroxide (H2O2)-induced oxidative damage in NG108-15 hybridoma cell line. Among these compounds, the gallotannins and ellagitannins exhibited remarkable neuroprotective activities against oxidative damage in vitro as compared to galloylated cyanogenic glucosides and ellagic acid derivatives in a dose-dependent manner. They could be explored further as potential natural neuroprotectors in various remedies of neurodegenerative diseases. Elsevier 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10294/1/Neuroprotective_activity_of_galloylated_cyanogenic_glucosides_and.pdf Tan, Hooi Poay and Wong, Daniel Zin Hua and Ling, Sui Kiong and Chuah, Cheng Hock and Kadir, Habsah Abdul (2012) Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia. Fitoterapia, 83 (1). pp. 223-229. ISSN 0367-326X https://doi.org/10.1016/j.fitote.2011.10.019 doi:10.1016/j.fitote.2011.10.019
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
language	English
topic	QD Chemistry QH Natural history
spellingShingle	QD Chemistry QH Natural history Tan, Hooi Poay Wong, Daniel Zin Hua Ling, Sui Kiong Chuah, Cheng Hock Kadir, Habsah Abdul Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia
description	The galloylated cyanogenic glucosides based on prunasin (1–7), gallotannins (8–14), ellagitannins (15–17), ellagic acid derivatives (18, 19) and gallic acid (20) isolated from the leaves of Phyllagathis rotundifolia (Melastomataceae) were investigated for their neuroprotective activity against hydrogen peroxide (H2O2)-induced oxidative damage in NG108-15 hybridoma cell line. Among these compounds, the gallotannins and ellagitannins exhibited remarkable neuroprotective activities against oxidative damage in vitro as compared to galloylated cyanogenic glucosides and ellagic acid derivatives in a dose-dependent manner. They could be explored further as potential natural neuroprotectors in various remedies of neurodegenerative diseases.
format	Article
author	Tan, Hooi Poay Wong, Daniel Zin Hua Ling, Sui Kiong Chuah, Cheng Hock Kadir, Habsah Abdul
author_facet	Tan, Hooi Poay Wong, Daniel Zin Hua Ling, Sui Kiong Chuah, Cheng Hock Kadir, Habsah Abdul
author_sort	Tan, Hooi Poay
title	Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia
title_short	Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia
title_full	Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia
title_fullStr	Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia
title_full_unstemmed	Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia
title_sort	neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of phyllagathis rotundifolia
publisher	Elsevier
publishDate	2012
url	http://eprints.um.edu.my/10294/1/Neuroprotective_activity_of_galloylated_cyanogenic_glucosides_and.pdf http://eprints.um.edu.my/10294/ https://doi.org/10.1016/j.fitote.2011.10.019
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score	13.211869

Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia

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