Polymorphisms in methylenetetrahydrofolate reductase gene and risk of non-Hodgkin lymphoma in a multi-ethnic population
An imbalance in folate metabolism can adversely affect DNA synthesis and methylation systems which can lead to susceptibility to non-Hodgkin lymphoma (NHL). Whether single nucleotide polymorphisms (SNPs) and their haplotypes in the methylenetetrahydrofolate reductase (MTHFR) are associated with NHL...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2014
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/10056/1/00005617_105899.pdf http://eprints.um.edu.my/10056/ |
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| Summary: | An imbalance in folate metabolism can adversely affect DNA synthesis and methylation systems which can lead to
susceptibility to non-Hodgkin lymphoma (NHL). Whether single nucleotide polymorphisms (SNPs) and their haplotypes in the methylenetetrahydrofolate reductase (MTHFR) are associated with NHL, remain inconclusive. We investigated the association between MTHFR C677T and A1298C SNPs and NHL risk in a population which is made up of Malay, Chinese and Indian ethnic subgroups. A total of 372 NHL patients and 722 controls were genotyped using the Sequenom MassARRAY platform.
Our results of the pooled subjects failed to demonstrate significant association between the MTHFR C677T and A1298C SNPs
with NHL and its subtypes. The results were in agreement with the previous meta-analyses. In the Indian ethnic subgroup
however, single locus analysis of MTHFR A1298C appears to confer risk to NHL (Odds ratio (OR) 1.91, 95% confidence
interval (95% CI) 1.22–3.00, P¼0.006). The risk is almost doubled in homozygous carrier of MTHFR 1298CC (OR 4.03,
95% CI 1.56–10.43, P¼0.004). Haplotype analysis revealed higher frequency of CC in the Indian NHL patients compared
with controls (OR 1.86, 95% CI 1.18–2.93, P¼0.007). There is lack of evidence to suggest an association between MTHFR
C677T and A1298C with the risk of NHL in the Malays and Chinese. In the Indians however, the MTHFR A1298C confers
risk to NHL. This study suggests ethnicity modifies the relationship between polymorphisms in the folate-metabolizing gene
and NHL. |
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