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Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah

The main objective of this project is to synthesize a stilbene analogue, 4-acetoxy-l 1,13- dibenzyloxystilbene at large scale in order to supply for bioactivity and reactivity investigations by other researchers. Three established reactions have been used in order to accomplish the project. First, t...

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Main Author: Abu Samah, Nor Hayati
Format: Thesis
Language:English
Published: 2005
Subjects:
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
Online Access:https://ir.uitm.edu.my/id/eprint/98657/1/98657.PDF
https://ir.uitm.edu.my/id/eprint/98657/
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spelling my.uitm.ir.986572024-07-22T08:02:14Z https://ir.uitm.edu.my/id/eprint/98657/ Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah Abu Samah, Nor Hayati RM Therapeutics. Pharmacology RS Pharmacy and materia medica The main objective of this project is to synthesize a stilbene analogue, 4-acetoxy-l 1,13- dibenzyloxystilbene at large scale in order to supply for bioactivity and reactivity investigations by other researchers. Three established reactions have been used in order to accomplish the project. First, the protection ofp-iodophenol using acetic anhydride to yield p-iodophenylacetale followed by the protection of 3,5-dihydroxybenzaldehyde with benzyl bromide that produced 3,5-dibenzyloxybenzaldehyde. Subsequently, the 3,5-dibenzyloxybenzaldehyde is utilized as a starting material of the Wittig reaction. Product of the Wittig reaction and /j-iodophenylaceate are then used to synthesize the stilbene analogue. The synthesized compounds are then, purified by chromatographic techniques and sent for 'H-NMR characterization. Concisely, even though the compound of desired has failed to be obtained, an almost structurally identical compound has been successfully synthesized in small amount. 2005 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/98657/1/98657.PDF Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah. (2005) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
spellingShingle RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
Abu Samah, Nor Hayati
Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah
description The main objective of this project is to synthesize a stilbene analogue, 4-acetoxy-l 1,13- dibenzyloxystilbene at large scale in order to supply for bioactivity and reactivity investigations by other researchers. Three established reactions have been used in order to accomplish the project. First, the protection ofp-iodophenol using acetic anhydride to yield p-iodophenylacetale followed by the protection of 3,5-dihydroxybenzaldehyde with benzyl bromide that produced 3,5-dibenzyloxybenzaldehyde. Subsequently, the 3,5-dibenzyloxybenzaldehyde is utilized as a starting material of the Wittig reaction. Product of the Wittig reaction and /j-iodophenylaceate are then used to synthesize the stilbene analogue. The synthesized compounds are then, purified by chromatographic techniques and sent for 'H-NMR characterization. Concisely, even though the compound of desired has failed to be obtained, an almost structurally identical compound has been successfully synthesized in small amount.
format Thesis
author Abu Samah, Nor Hayati
author_facet Abu Samah, Nor Hayati
author_sort Abu Samah, Nor Hayati
title Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah
title_short Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah
title_full Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah
title_fullStr Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah
title_full_unstemmed Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah
title_sort synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / nor hayati abu samah
publishDate 2005
url https://ir.uitm.edu.my/id/eprint/98657/1/98657.PDF
https://ir.uitm.edu.my/id/eprint/98657/
_version_ 1806422116493426688
score 13.211869

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