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Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab

The World Health Organization (WHO) in 1997 recommended that effective locally available plants should be used as substitutes for drugs. Psidium guajava or guava is one of local plants found in abundance in Malaysia. The pharmacological effects, specifically on locomotor activity and central nervous...

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Main Author: Abd Wahab, Mohd Shahezwan
Format: Thesis
Language:English
Published: 2005
Subjects:
RM Therapeutics. Pharmacology
Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Online Access:https://ir.uitm.edu.my/id/eprint/98481/1/98481.PDF
https://ir.uitm.edu.my/id/eprint/98481/
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spelling my.uitm.ir.984812024-08-27T18:11:34Z https://ir.uitm.edu.my/id/eprint/98481/ Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab Abd Wahab, Mohd Shahezwan RM Therapeutics. Pharmacology Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) The World Health Organization (WHO) in 1997 recommended that effective locally available plants should be used as substitutes for drugs. Psidium guajava or guava is one of local plants found in abundance in Malaysia. The pharmacological effects, specifically on locomotor activity and central nervous system by the plant should be exploited for clinical use. This study is carried out to evaluate the effects of Psidium guajava leaf extract on the locomotor activity, central nervous system and also on the intake of food and water in mice. For the evaluation of locomotor activity of the mice, the Animal Activity Monitor by Coulboum Instrument is used. The extract at doses of 1, 3 and 5 mg/kg was acutely and chronically administered through the intraperitoneal route to male adult mice (n = 5 per group) before they were subjected to the experiment. Normal saline was administered as control. The instrument is also used to investigate the effect of the Psidium guajava leaf extract on food and water intake of the mice. Forced swimming test was implemented to study the depressant effect of the mice. Depressive activity on the central nervous system was demonstrated by several alterations in the mice behaviour in the pharmacological screening. The results obtained showed that the leaf extract caused reduction of locomotor activity as well as reduction in food and water intake in mice. The extract also produces central nervous system depressant effects. Further studies should be conducted to uncover the mechanism of action and also possible therapeutic use. 2005 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/98481/1/98481.PDF Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab. (2005) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic RM Therapeutics. Pharmacology
Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
spellingShingle RM Therapeutics. Pharmacology
Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Abd Wahab, Mohd Shahezwan
Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab
description The World Health Organization (WHO) in 1997 recommended that effective locally available plants should be used as substitutes for drugs. Psidium guajava or guava is one of local plants found in abundance in Malaysia. The pharmacological effects, specifically on locomotor activity and central nervous system by the plant should be exploited for clinical use. This study is carried out to evaluate the effects of Psidium guajava leaf extract on the locomotor activity, central nervous system and also on the intake of food and water in mice. For the evaluation of locomotor activity of the mice, the Animal Activity Monitor by Coulboum Instrument is used. The extract at doses of 1, 3 and 5 mg/kg was acutely and chronically administered through the intraperitoneal route to male adult mice (n = 5 per group) before they were subjected to the experiment. Normal saline was administered as control. The instrument is also used to investigate the effect of the Psidium guajava leaf extract on food and water intake of the mice. Forced swimming test was implemented to study the depressant effect of the mice. Depressive activity on the central nervous system was demonstrated by several alterations in the mice behaviour in the pharmacological screening. The results obtained showed that the leaf extract caused reduction of locomotor activity as well as reduction in food and water intake in mice. The extract also produces central nervous system depressant effects. Further studies should be conducted to uncover the mechanism of action and also possible therapeutic use.
format Thesis
author Abd Wahab, Mohd Shahezwan
author_facet Abd Wahab, Mohd Shahezwan
author_sort Abd Wahab, Mohd Shahezwan
title Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab
title_short Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab
title_full Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab
title_fullStr Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab
title_full_unstemmed Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab
title_sort pharmacological behavioural effects of psidium guajava leaf extract / mohd shahezwan abd wahab
publishDate 2005
url https://ir.uitm.edu.my/id/eprint/98481/1/98481.PDF
https://ir.uitm.edu.my/id/eprint/98481/
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score 13.211869

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