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Polyvinylpyrrolidone wrapped single walled carbon nanotubes: solid state characterization and superior antimicrobial activity / Mazzura Wan Chik

Single walled carbon nanotubes (SWNTs) are special in a way that they perform varies physical and chemical characteristics with diverse applications in many fields of scientific research. Despite their outstanding characteristics, SWNTs is challenged by its poor aqueous solubility property due to it...

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Main Author: Wan Chik, Mazzura
Format: Thesis
Language:English
Published: 2019
Online Access:https://ir.uitm.edu.my/id/eprint/91411/1/91411.pdf
https://ir.uitm.edu.my/id/eprint/91411/
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spelling my.uitm.ir.914112024-03-20T16:29:04Z https://ir.uitm.edu.my/id/eprint/91411/ Polyvinylpyrrolidone wrapped single walled carbon nanotubes: solid state characterization and superior antimicrobial activity / Mazzura Wan Chik Wan Chik, Mazzura Single walled carbon nanotubes (SWNTs) are special in a way that they perform varies physical and chemical characteristics with diverse applications in many fields of scientific research. Despite their outstanding characteristics, SWNTs is challenged by its poor aqueous solubility property due to its super hydrophobicity that becomes a hindrance for their application in many important areas including pharmaceutical life sciences. Previously, the functionalization (f-) and non-covalent functionalization (non-covalent-f) methods have been explored to increase solubility of SWNTs. However, the f- method is said to affect the intrinsic properties of SWNTs while the non-covalent-f by polymer wrapping does not. This study shall elucidate the solid state characterization, the probable antimicrobial and antiphysiologic effects of the synthesized polymer polyvinylpyrrolidone wrapped SWNTs (PVP-SWNTs) on bacterial Escherichia coli (E. coli). First, the characterization of pure SWNTs, PVP and PVP-SWNTs in solid state was determined. These powdered materials were brought to spectral analysis, and thermophysical assay. Results indicated that the solubility of SWNTs in water had increased when aided with PVP wrapping. Results of the spectral analysis revealed that the unprocessed PVP spectra appeared dominantly in the PVP-SWNTs spectral analysis indicating wrapping of PVP over SWNTs. While, the thermophysical study showed formation of endothermic melting peaks of PVP appeared on PVP-SWNTs thermogram which could be interpreted as engagement between PVP and SWNTs. The second part of the study looked at antimicrobial and antiphysiologic activities of dispersed PVP-SWNTs and naked SWNTs on E. coli. The conventional antimicrobial study revealed that at 1 mg/ml PVP-SWNTs were able to inhibit the growth of E. coli and reduced 95 % of optical density (OD) readings. Finally, increased concentration of PVP-SWNTs and SWNTs showed better antiphysiologic activities towards E. coli (maximum concentration is 11.5 v/v % equivalents to 300 μg). The one-way ANOVA showed significant results between groups (p = 0.002). 2019 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/91411/1/91411.pdf Polyvinylpyrrolidone wrapped single walled carbon nanotubes: solid state characterization and superior antimicrobial activity / Mazzura Wan Chik. (2019) Masters thesis, thesis, Universiti Teknologi MARA (UiTM).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
description Single walled carbon nanotubes (SWNTs) are special in a way that they perform varies physical and chemical characteristics with diverse applications in many fields of scientific research. Despite their outstanding characteristics, SWNTs is challenged by its poor aqueous solubility property due to its super hydrophobicity that becomes a hindrance for their application in many important areas including pharmaceutical life sciences. Previously, the functionalization (f-) and non-covalent functionalization (non-covalent-f) methods have been explored to increase solubility of SWNTs. However, the f- method is said to affect the intrinsic properties of SWNTs while the non-covalent-f by polymer wrapping does not. This study shall elucidate the solid state characterization, the probable antimicrobial and antiphysiologic effects of the synthesized polymer polyvinylpyrrolidone wrapped SWNTs (PVP-SWNTs) on bacterial Escherichia coli (E. coli). First, the characterization of pure SWNTs, PVP and PVP-SWNTs in solid state was determined. These powdered materials were brought to spectral analysis, and thermophysical assay. Results indicated that the solubility of SWNTs in water had increased when aided with PVP wrapping. Results of the spectral analysis revealed that the unprocessed PVP spectra appeared dominantly in the PVP-SWNTs spectral analysis indicating wrapping of PVP over SWNTs. While, the thermophysical study showed formation of endothermic melting peaks of PVP appeared on PVP-SWNTs thermogram which could be interpreted as engagement between PVP and SWNTs. The second part of the study looked at antimicrobial and antiphysiologic activities of dispersed PVP-SWNTs and naked SWNTs on E. coli. The conventional antimicrobial study revealed that at 1 mg/ml PVP-SWNTs were able to inhibit the growth of E. coli and reduced 95 % of optical density (OD) readings. Finally, increased concentration of PVP-SWNTs and SWNTs showed better antiphysiologic activities towards E. coli (maximum concentration is 11.5 v/v % equivalents to 300 μg). The one-way ANOVA showed significant results between groups (p = 0.002).
format Thesis
author Wan Chik, Mazzura
spellingShingle Wan Chik, Mazzura
Polyvinylpyrrolidone wrapped single walled carbon nanotubes: solid state characterization and superior antimicrobial activity / Mazzura Wan Chik
author_facet Wan Chik, Mazzura
author_sort Wan Chik, Mazzura
title Polyvinylpyrrolidone wrapped single walled carbon nanotubes: solid state characterization and superior antimicrobial activity / Mazzura Wan Chik
title_short Polyvinylpyrrolidone wrapped single walled carbon nanotubes: solid state characterization and superior antimicrobial activity / Mazzura Wan Chik
title_full Polyvinylpyrrolidone wrapped single walled carbon nanotubes: solid state characterization and superior antimicrobial activity / Mazzura Wan Chik
title_fullStr Polyvinylpyrrolidone wrapped single walled carbon nanotubes: solid state characterization and superior antimicrobial activity / Mazzura Wan Chik
title_full_unstemmed Polyvinylpyrrolidone wrapped single walled carbon nanotubes: solid state characterization and superior antimicrobial activity / Mazzura Wan Chik
title_sort polyvinylpyrrolidone wrapped single walled carbon nanotubes: solid state characterization and superior antimicrobial activity / mazzura wan chik
publishDate 2019
url https://ir.uitm.edu.my/id/eprint/91411/1/91411.pdf
https://ir.uitm.edu.my/id/eprint/91411/
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score 13.211869

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