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Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi

Erythrina fusca (Fabaceae) is a red flowering plant belonging to the Erythrina genus. Traditionally, this plant has been claimed to have therapeutic effects on certain symptoms associated with bacterial infections. Although the reported therapeutic activities of the plant are attributed to its alkal...

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Main Author: Azmi, Adiez Sapura
Format: Thesis
Language:English
Published: 2023
Subjects:
QK Botany
Online Access:https://ir.uitm.edu.my/id/eprint/91034/1/91034.pdf
https://ir.uitm.edu.my/id/eprint/91034/
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spelling my.uitm.ir.910342024-07-22T03:01:19Z https://ir.uitm.edu.my/id/eprint/91034/ Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi Azmi, Adiez Sapura QK Botany Erythrina fusca (Fabaceae) is a red flowering plant belonging to the Erythrina genus. Traditionally, this plant has been claimed to have therapeutic effects on certain symptoms associated with bacterial infections. Although the reported therapeutic activities of the plant are attributed to its alkaloidal content, there is currently no scientific data available to support these claims, particularly regarding the antibacterial activity of the plant against bacterial strains commonly responsible for human infections. Therefore, the objectives of this study were; 1) to extracts alkaloids from E. fusca's, leaves using a tartaric and hydrochloric acids through acid-base extraction, 2) to evaluate the antibacterial activity of extracts obtained from different parts of E.fusca (leaves, twigs, and flowers) against four human infectious bacterial strains, namely Staphylococcus aureus, Staphylococcus haemolyticus, Enterobacter cloacae, and Enterobacter aerogenes; 3) to profile and identify the phytochemicals present in the extracts, 4) to determine the variation of phytochemicals between the extracts and the correlation with their antibacterial activity. The antibacterial activity was evaluated using well diffusion method with ciprofloxacin as the positive control. The phytochemicals were profiled and identified using proton nuclear magnetic resonance (JH NMR)-based data analysis, while the phytochemicals variation between different extracts and their correlation with antibacterial activity were determined using principal component analysis (PCA), partial least square discriminant analysis (PLS-DA) and partial least square (PLS) regression. 2023 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/91034/1/91034.pdf Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi. (2023) Masters thesis, thesis, Universiti Teknologi MARA (UiTM). <http://terminalib.uitm.edu.my/91034.pdf>
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic QK Botany
spellingShingle QK Botany
Azmi, Adiez Sapura
Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi
description Erythrina fusca (Fabaceae) is a red flowering plant belonging to the Erythrina genus. Traditionally, this plant has been claimed to have therapeutic effects on certain symptoms associated with bacterial infections. Although the reported therapeutic activities of the plant are attributed to its alkaloidal content, there is currently no scientific data available to support these claims, particularly regarding the antibacterial activity of the plant against bacterial strains commonly responsible for human infections. Therefore, the objectives of this study were; 1) to extracts alkaloids from E. fusca's, leaves using a tartaric and hydrochloric acids through acid-base extraction, 2) to evaluate the antibacterial activity of extracts obtained from different parts of E.fusca (leaves, twigs, and flowers) against four human infectious bacterial strains, namely Staphylococcus aureus, Staphylococcus haemolyticus, Enterobacter cloacae, and Enterobacter aerogenes; 3) to profile and identify the phytochemicals present in the extracts, 4) to determine the variation of phytochemicals between the extracts and the correlation with their antibacterial activity. The antibacterial activity was evaluated using well diffusion method with ciprofloxacin as the positive control. The phytochemicals were profiled and identified using proton nuclear magnetic resonance (JH NMR)-based data analysis, while the phytochemicals variation between different extracts and their correlation with antibacterial activity were determined using principal component analysis (PCA), partial least square discriminant analysis (PLS-DA) and partial least square (PLS) regression.
format Thesis
author Azmi, Adiez Sapura
author_facet Azmi, Adiez Sapura
author_sort Azmi, Adiez Sapura
title Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi
title_short Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi
title_full Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi
title_fullStr Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi
title_full_unstemmed Profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton NMR-based chemometric approach / Adiez Sapura Azmi
title_sort profiling and identification of phytochemicals from erythrina fusca extracts and their activity against skin infectious bacterial strains through proton nmr-based chemometric approach / adiez sapura azmi
publishDate 2023
url https://ir.uitm.edu.my/id/eprint/91034/1/91034.pdf
https://ir.uitm.edu.my/id/eprint/91034/
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score 13.211869

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