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Analysis of immediate radiation effects on osteoporotic bone morphology and mechanical properties / Ayuni Amalina Abu Bakar

Introduction: Although bone architecture and its mechanical properties are known to deteriorate after radiotherapy, the effects of radiation on osteoporotic bones in menopause patients have not been fully understood. Therefore, this study investigates the effects of radiation on the osteoporotic fem...

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Main Author: Abu Bakar, Ayuni Amalina
Format: Thesis
Language:English
Published: 2023
Online Access:https://ir.uitm.edu.my/id/eprint/88698/1/88698.pdf
https://ir.uitm.edu.my/id/eprint/88698/
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spelling my.uitm.ir.886982023-12-26T09:26:47Z https://ir.uitm.edu.my/id/eprint/88698/ Analysis of immediate radiation effects on osteoporotic bone morphology and mechanical properties / Ayuni Amalina Abu Bakar Abu Bakar, Ayuni Amalina Introduction: Although bone architecture and its mechanical properties are known to deteriorate after radiotherapy, the effects of radiation on osteoporotic bones in menopause patients have not been fully understood. Therefore, this study investigates the effects of radiation on the osteoporotic femur of menopause-induced mice. Materials and Methods: Ovari ectomy was performed on 38-week-old BALB/c mice (n=6) to induce menopause and osteoporosis, and the animals were allowed to recover for 10 weeks. Then, the mice in the irradiated group were exposed to Caesium-137 Chloride sources at a dose of 30 Gy. After seven days, all mice were euthanised and their femurs were dissected. Micro-computed tomography (μCT Skyscan 1172) was performed on the distal femurs at voxel size of 8 μm in 20-minute scans, and the bones were quantified using a CT-analyser. Thereafter, bone durability was analysed in a three-point bending simulation (ANSYS Workbench software version 2020 R1). Results: μCT analysis showed that irradiated mice had reduced bone volume (-41.65 %), trabecular number (-30.56 %) and trabecular thickness (- 21 %), besides increased trabecular separation (50.95 %) compared with control littermates. The same trend was observed in the cortical bone at the diaphysis region. There was reduction in total area (-1.75 %) and cortical area (-4 %) despite an increase in cortical thickness (10.56 %). Additionally, cortical stiffness and flexural strength was also significantly reduced by -35.06 % and 18 %. Conclusion: The findings show that irradiation can alter the microarchitecture and mechanical properties of bones in an animal model. Hence, targeted therapy strategies should be improved to reduce the deleterious effects on the bone caused by the irradiation. 2023 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/88698/1/88698.pdf Analysis of immediate radiation effects on osteoporotic bone morphology and mechanical properties / Ayuni Amalina Abu Bakar. (2023) Masters thesis, thesis, Universiti Teknologi MARA (UiTM).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
description Introduction: Although bone architecture and its mechanical properties are known to deteriorate after radiotherapy, the effects of radiation on osteoporotic bones in menopause patients have not been fully understood. Therefore, this study investigates the effects of radiation on the osteoporotic femur of menopause-induced mice. Materials and Methods: Ovari ectomy was performed on 38-week-old BALB/c mice (n=6) to induce menopause and osteoporosis, and the animals were allowed to recover for 10 weeks. Then, the mice in the irradiated group were exposed to Caesium-137 Chloride sources at a dose of 30 Gy. After seven days, all mice were euthanised and their femurs were dissected. Micro-computed tomography (μCT Skyscan 1172) was performed on the distal femurs at voxel size of 8 μm in 20-minute scans, and the bones were quantified using a CT-analyser. Thereafter, bone durability was analysed in a three-point bending simulation (ANSYS Workbench software version 2020 R1). Results: μCT analysis showed that irradiated mice had reduced bone volume (-41.65 %), trabecular number (-30.56 %) and trabecular thickness (- 21 %), besides increased trabecular separation (50.95 %) compared with control littermates. The same trend was observed in the cortical bone at the diaphysis region. There was reduction in total area (-1.75 %) and cortical area (-4 %) despite an increase in cortical thickness (10.56 %). Additionally, cortical stiffness and flexural strength was also significantly reduced by -35.06 % and 18 %. Conclusion: The findings show that irradiation can alter the microarchitecture and mechanical properties of bones in an animal model. Hence, targeted therapy strategies should be improved to reduce the deleterious effects on the bone caused by the irradiation.
format Thesis
author Abu Bakar, Ayuni Amalina
spellingShingle Abu Bakar, Ayuni Amalina
Analysis of immediate radiation effects on osteoporotic bone morphology and mechanical properties / Ayuni Amalina Abu Bakar
author_facet Abu Bakar, Ayuni Amalina
author_sort Abu Bakar, Ayuni Amalina
title Analysis of immediate radiation effects on osteoporotic bone morphology and mechanical properties / Ayuni Amalina Abu Bakar
title_short Analysis of immediate radiation effects on osteoporotic bone morphology and mechanical properties / Ayuni Amalina Abu Bakar
title_full Analysis of immediate radiation effects on osteoporotic bone morphology and mechanical properties / Ayuni Amalina Abu Bakar
title_fullStr Analysis of immediate radiation effects on osteoporotic bone morphology and mechanical properties / Ayuni Amalina Abu Bakar
title_full_unstemmed Analysis of immediate radiation effects on osteoporotic bone morphology and mechanical properties / Ayuni Amalina Abu Bakar
title_sort analysis of immediate radiation effects on osteoporotic bone morphology and mechanical properties / ayuni amalina abu bakar
publishDate 2023
url https://ir.uitm.edu.my/id/eprint/88698/1/88698.pdf
https://ir.uitm.edu.my/id/eprint/88698/
_version_ 1787139629038698496
score 13.211869

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