Staff View: Microbial biotransformation of male specific pheromone α-copaene with cunninghamella elegans and antibacterial activity of its transformed products / Syed Adnan Ali Shah ... [et al.]

Microbial biotransformation of male specific pheromone α-copaene with cunninghamella elegans and antibacterial activity of its transformed products / Syed Adnan Ali Shah ... [et al.]

Pharmaceutical industries are increasingly turning to microbial transformation instead of chemical methods. This is because microbial biotransformation is a more effective way to produce pharmacologically active molecules with high specificity and efficient yield. Additionally, it is a step towards...

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Main Authors:	Ali Shah, Syed Adnan, Atif, Muhammad, Sultan, Sadia, Erum, Saira, Hussain, Samreen
Format:	Article
Language:	English
Published:	Faculty of Pharmacy 2023
Subjects:	QR Microbiology Bacteria
Online Access:	https://ir.uitm.edu.my/id/eprint/86721/1/86721.pdf https://ir.uitm.edu.my/id/eprint/86721/
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id	my.uitm.ir.86721
record_format	eprints
spelling	my.uitm.ir.867212024-05-23T04:05:15Z https://ir.uitm.edu.my/id/eprint/86721/ Microbial biotransformation of male specific pheromone α-copaene with cunninghamella elegans and antibacterial activity of its transformed products / Syed Adnan Ali Shah ... [et al.] ijpnacs Ali Shah, Syed Adnan Atif, Muhammad Sultan, Sadia Erum, Saira Hussain, Samreen QR Microbiology Bacteria Pharmaceutical industries are increasingly turning to microbial transformation instead of chemical methods. This is because microbial biotransformation is a more effective way to produce pharmacologically active molecules with high specificity and efficient yield. Additionally, it is a step towards eco-friendly synthesis. α-Copaene (1), a tricyclic sesquiterpene, is a potent attractant of the male Mediterranean fruit fly Ceratitis capitata. This paper presents the utilization of the filamentous fungus Cunninghamella elegans TSY 0865 for large-scale biotransformation of 1. α-Copaene (1) has been incubated with Cunninghamella elegans for 11 days and extracted with CH 2 Cl 2 . Four new hydroxylated metabolites 10,13-dihydroxycopaene (2); 11,13-dihydroxycopaene (3); 11-hydroxycopaen-5-one (4); and 11-hydroxy-13-copaenic acid (5) were afforded. The structures of the new metabolites were elucidated by 1D ( 1 H, 13 C) and 2D NMR (COSY, HMBC, HMQC, and NOESY) techniques and MS analyses. Metabolite 5 exhibited significant antibacterial activity against Bacillus subtilis and Pseudomonas aeruginosa. Faculty of Pharmacy 2023 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/86721/1/86721.pdf Microbial biotransformation of male specific pheromone α-copaene with cunninghamella elegans and antibacterial activity of its transformed products / Syed Adnan Ali Shah ... [et al.]. (2023) International Journal of Pharmaceuticals, Nutraceuticals and Cosmetic Science (IJPNaCS) <https://ir.uitm.edu.my/view/publication/International_Journal_of_Pharmaceuticals,_Nutraceuticals_and_Cosmetic_Science_=28IJPNaCS=29/>, 6 (1). pp. 39-48. ISSN 2682-8146
institution	Universiti Teknologi Mara
building	Tun Abdul Razak Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Mara
content_source	UiTM Institutional Repository
url_provider	http://ir.uitm.edu.my/
language	English
topic	QR Microbiology Bacteria
spellingShingle	QR Microbiology Bacteria Ali Shah, Syed Adnan Atif, Muhammad Sultan, Sadia Erum, Saira Hussain, Samreen Microbial biotransformation of male specific pheromone α-copaene with cunninghamella elegans and antibacterial activity of its transformed products / Syed Adnan Ali Shah ... [et al.]
description	Pharmaceutical industries are increasingly turning to microbial transformation instead of chemical methods. This is because microbial biotransformation is a more effective way to produce pharmacologically active molecules with high specificity and efficient yield. Additionally, it is a step towards eco-friendly synthesis. α-Copaene (1), a tricyclic sesquiterpene, is a potent attractant of the male Mediterranean fruit fly Ceratitis capitata. This paper presents the utilization of the filamentous fungus Cunninghamella elegans TSY 0865 for large-scale biotransformation of 1. α-Copaene (1) has been incubated with Cunninghamella elegans for 11 days and extracted with CH 2 Cl 2 . Four new hydroxylated metabolites 10,13-dihydroxycopaene (2); 11,13-dihydroxycopaene (3); 11-hydroxycopaen-5-one (4); and 11-hydroxy-13-copaenic acid (5) were afforded. The structures of the new metabolites were elucidated by 1D ( 1 H, 13 C) and 2D NMR (COSY, HMBC, HMQC, and NOESY) techniques and MS analyses. Metabolite 5 exhibited significant antibacterial activity against Bacillus subtilis and Pseudomonas aeruginosa.
format	Article
author	Ali Shah, Syed Adnan Atif, Muhammad Sultan, Sadia Erum, Saira Hussain, Samreen
author_facet	Ali Shah, Syed Adnan Atif, Muhammad Sultan, Sadia Erum, Saira Hussain, Samreen
author_sort	Ali Shah, Syed Adnan
title	Microbial biotransformation of male specific pheromone α-copaene with cunninghamella elegans and antibacterial activity of its transformed products / Syed Adnan Ali Shah ... [et al.]
title_short	Microbial biotransformation of male specific pheromone α-copaene with cunninghamella elegans and antibacterial activity of its transformed products / Syed Adnan Ali Shah ... [et al.]
title_full	Microbial biotransformation of male specific pheromone α-copaene with cunninghamella elegans and antibacterial activity of its transformed products / Syed Adnan Ali Shah ... [et al.]
title_fullStr	Microbial biotransformation of male specific pheromone α-copaene with cunninghamella elegans and antibacterial activity of its transformed products / Syed Adnan Ali Shah ... [et al.]
title_full_unstemmed	Microbial biotransformation of male specific pheromone α-copaene with cunninghamella elegans and antibacterial activity of its transformed products / Syed Adnan Ali Shah ... [et al.]
title_sort	microbial biotransformation of male specific pheromone α-copaene with cunninghamella elegans and antibacterial activity of its transformed products / syed adnan ali shah ... [et al.]
publisher	Faculty of Pharmacy
publishDate	2023
url	https://ir.uitm.edu.my/id/eprint/86721/1/86721.pdf https://ir.uitm.edu.my/id/eprint/86721/
_version_	1800100697240240128
score	13.211869

Microbial biotransformation of male specific pheromone α-copaene with cunninghamella elegans and antibacterial activity of its transformed products / Syed Adnan Ali Shah ... [et al.]

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