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Pulmonary inhalation performance of chitosan nanoparticles admixed with lactose-poly ethylene glycol microparticles / Nasser Ahmed Mohammed Al Hajj

Nanoparticles are characterized by poor pulmonary inhalation performance as they are exhalation prone, in addition to their tendency to form agglomeration due to large surface area to volume ratio thereby hindering their deep lung deposition. Coarse carriers commonly used in dry powder inhaler canno...

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Main Author: Mohammed Al Hajj, Nasser Ahmed
Format: Thesis
Language:English
Published: 2016
Online Access:https://ir.uitm.edu.my/id/eprint/84238/1/84238.pdf
https://ir.uitm.edu.my/id/eprint/84238/
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record_format eprints
spelling my.uitm.ir.842382024-03-07T03:38:43Z https://ir.uitm.edu.my/id/eprint/84238/ Pulmonary inhalation performance of chitosan nanoparticles admixed with lactose-poly ethylene glycol microparticles / Nasser Ahmed Mohammed Al Hajj Mohammed Al Hajj, Nasser Ahmed Nanoparticles are characterized by poor pulmonary inhalation performance as they are exhalation prone, in addition to their tendency to form agglomeration due to large surface area to volume ratio thereby hindering their deep lung deposition. Coarse carriers commonly used in dry powder inhaler cannot be used to deliver nanoparticles to the lung. The nanoparticles will be attach strongly to them and deposit in the throat, or they will detach, enter the lung and be exhaled. This study aimed to develop a platform where the nanoparticles were distributed over the microparticles for pulmonary delivery of nanoparticulate system. 2016 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/84238/1/84238.pdf Pulmonary inhalation performance of chitosan nanoparticles admixed with lactose-poly ethylene glycol microparticles / Nasser Ahmed Mohammed Al Hajj. (2016) Masters thesis, thesis, Universiti Teknologi MARA (UiTM).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
description Nanoparticles are characterized by poor pulmonary inhalation performance as they are exhalation prone, in addition to their tendency to form agglomeration due to large surface area to volume ratio thereby hindering their deep lung deposition. Coarse carriers commonly used in dry powder inhaler cannot be used to deliver nanoparticles to the lung. The nanoparticles will be attach strongly to them and deposit in the throat, or they will detach, enter the lung and be exhaled. This study aimed to develop a platform where the nanoparticles were distributed over the microparticles for pulmonary delivery of nanoparticulate system.
format Thesis
author Mohammed Al Hajj, Nasser Ahmed
spellingShingle Mohammed Al Hajj, Nasser Ahmed
Pulmonary inhalation performance of chitosan nanoparticles admixed with lactose-poly ethylene glycol microparticles / Nasser Ahmed Mohammed Al Hajj
author_facet Mohammed Al Hajj, Nasser Ahmed
author_sort Mohammed Al Hajj, Nasser Ahmed
title Pulmonary inhalation performance of chitosan nanoparticles admixed with lactose-poly ethylene glycol microparticles / Nasser Ahmed Mohammed Al Hajj
title_short Pulmonary inhalation performance of chitosan nanoparticles admixed with lactose-poly ethylene glycol microparticles / Nasser Ahmed Mohammed Al Hajj
title_full Pulmonary inhalation performance of chitosan nanoparticles admixed with lactose-poly ethylene glycol microparticles / Nasser Ahmed Mohammed Al Hajj
title_fullStr Pulmonary inhalation performance of chitosan nanoparticles admixed with lactose-poly ethylene glycol microparticles / Nasser Ahmed Mohammed Al Hajj
title_full_unstemmed Pulmonary inhalation performance of chitosan nanoparticles admixed with lactose-poly ethylene glycol microparticles / Nasser Ahmed Mohammed Al Hajj
title_sort pulmonary inhalation performance of chitosan nanoparticles admixed with lactose-poly ethylene glycol microparticles / nasser ahmed mohammed al hajj
publishDate 2016
url https://ir.uitm.edu.my/id/eprint/84238/1/84238.pdf
https://ir.uitm.edu.my/id/eprint/84238/
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score 13.211869

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