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Determination of gallic acid using different extraction solvent on Azadirachta indica / Nur Sakinah Noor Azman

Azadirachta indica (neem) is a member of the Meliaceae family, and its effectiveness as a health-promoting plant is attributed to its bio-active compounds. It has traditionally been used in Chinese, Ayurvedic, and Unani medicine, particularly in the Indian Subcontinent, to cure and prevent a various...

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Main Author: Noor Azman, Nur Sakinah
Format: Student Project
Language:English
Published: 2023
Subjects:
Biochemistry
Extraction (Chemistry)
Online Access:https://ir.uitm.edu.my/id/eprint/78516/1/78516.pdf
https://ir.uitm.edu.my/id/eprint/78516/
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spelling my.uitm.ir.785162023-05-29T01:57:49Z https://ir.uitm.edu.my/id/eprint/78516/ Determination of gallic acid using different extraction solvent on Azadirachta indica / Nur Sakinah Noor Azman Noor Azman, Nur Sakinah Biochemistry Extraction (Chemistry) Azadirachta indica (neem) is a member of the Meliaceae family, and its effectiveness as a health-promoting plant is attributed to its bio-active compounds. It has traditionally been used in Chinese, Ayurvedic, and Unani medicine, particularly in the Indian Subcontinent, to cure and prevent a various human diseases. The bio-active compounds found in the plant have shown the efficacy of neem leaves in medical and consumer goods. These bio-active compounds can be obtained by using an optimum and appropriate extraction parameter. The extraction parameters include suitable drying methods, suitable solvents to extract polar or non-polar compounds, types of extraction technique and others. However, the comparative scientific study on the effect of using different extraction parameter towards the the extraction yield and amount of extracted bio-active compound has been very limited. Therefore, this research study was conducted in order to find a solvent capable of extracting the optimum extract yield and gallic acid. Acetone, ethyl acetate, and hexane were selected as extraction medium, and maceration technique was conducted to test which solvent yielded the most neem extract. The concentration of gallic acid in each extract was determine by using High Performance Liquid Chromatography (HPLC) test was observed after the extract is obtained. The highest yield obtained was ethyl acetate extract about 13.59%, followed by acetone and hexane extract 3.23% and 1.06% respectively. The crude oil of extraction is all greenish brown and smelly, with a high viscosity of solution. The highest concentration of gallic acid was found from hexane extract with the value of 46.08ppm. Therefore, maceration extraction is considered as an alternative process for obtaining the bio-active gallic acid compounds with high concentration from neem leaves by using hexane as a solvents. 2023 Student Project NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/78516/1/78516.pdf Determination of gallic acid using different extraction solvent on Azadirachta indica / Nur Sakinah Noor Azman. (2023) [Student Project] (Submitted)
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Biochemistry
Extraction (Chemistry)
spellingShingle Biochemistry
Extraction (Chemistry)
Noor Azman, Nur Sakinah
Determination of gallic acid using different extraction solvent on Azadirachta indica / Nur Sakinah Noor Azman
description Azadirachta indica (neem) is a member of the Meliaceae family, and its effectiveness as a health-promoting plant is attributed to its bio-active compounds. It has traditionally been used in Chinese, Ayurvedic, and Unani medicine, particularly in the Indian Subcontinent, to cure and prevent a various human diseases. The bio-active compounds found in the plant have shown the efficacy of neem leaves in medical and consumer goods. These bio-active compounds can be obtained by using an optimum and appropriate extraction parameter. The extraction parameters include suitable drying methods, suitable solvents to extract polar or non-polar compounds, types of extraction technique and others. However, the comparative scientific study on the effect of using different extraction parameter towards the the extraction yield and amount of extracted bio-active compound has been very limited. Therefore, this research study was conducted in order to find a solvent capable of extracting the optimum extract yield and gallic acid. Acetone, ethyl acetate, and hexane were selected as extraction medium, and maceration technique was conducted to test which solvent yielded the most neem extract. The concentration of gallic acid in each extract was determine by using High Performance Liquid Chromatography (HPLC) test was observed after the extract is obtained. The highest yield obtained was ethyl acetate extract about 13.59%, followed by acetone and hexane extract 3.23% and 1.06% respectively. The crude oil of extraction is all greenish brown and smelly, with a high viscosity of solution. The highest concentration of gallic acid was found from hexane extract with the value of 46.08ppm. Therefore, maceration extraction is considered as an alternative process for obtaining the bio-active gallic acid compounds with high concentration from neem leaves by using hexane as a solvents.
format Student Project
author Noor Azman, Nur Sakinah
author_facet Noor Azman, Nur Sakinah
author_sort Noor Azman, Nur Sakinah
title Determination of gallic acid using different extraction solvent on Azadirachta indica / Nur Sakinah Noor Azman
title_short Determination of gallic acid using different extraction solvent on Azadirachta indica / Nur Sakinah Noor Azman
title_full Determination of gallic acid using different extraction solvent on Azadirachta indica / Nur Sakinah Noor Azman
title_fullStr Determination of gallic acid using different extraction solvent on Azadirachta indica / Nur Sakinah Noor Azman
title_full_unstemmed Determination of gallic acid using different extraction solvent on Azadirachta indica / Nur Sakinah Noor Azman
title_sort determination of gallic acid using different extraction solvent on azadirachta indica / nur sakinah noor azman
publishDate 2023
url https://ir.uitm.edu.my/id/eprint/78516/1/78516.pdf
https://ir.uitm.edu.my/id/eprint/78516/
_version_ 1768011712970096640
score 13.211869

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